Molecular Detection of TEL-AML1 Transcripts as a Diagnostic Tool and for Monitoring of Minimal Residual Disease in B-lineage Childhood Acute Lymphoblastic Leukemia

TEL/AML1 rearrangement and the prognostic significance in childhood acute lymphoblastic leukemia in Hong Kong

“…Recent studies showed that the prevalence of TEL/ AML1 rearrangement resulting from the t(12;21) varies notably in newly diagnosed childhood ALL, ranging from 0-33% [8][9][10][11][12][13][14][15][16][17][18][19], and the fusion gene was suggested to be an independent good prognostic factor. Most studies were performed on Caucasian populations and only a few studies were carried out among Asian populations.…”