<i>TEL/AML1</i> rearrangement and the prognostic significance in childhood acute lymphoblastic leukemia in Hong Kong

Tsang, Kam Sze; Li, Chi Kong; Chik, Ki Wai; Shing, Matthew Ming Kong; Tsoi, Wai Chiu; Ng, Margaret H.L.; Lau, Tai Tap; Leung, Yu Hang; Yuen, Patrick Man Pan

doi:10.1002/ajh.1159

Cited by 41 publications

(40 citation statements)

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“…21,22,32,40,41 The 25% incidence rate of TEL/AML1 þ cases in our study is in the upper range of the 18-26% reported in RT-PCR screening surveys. [3][4][5][6][9][10][11][12][13] In line with most of these reports, patients included in our analysis also presented with well-known good prognostic features at initial diagnosis. However, the prognostic relevance of TEL/AML1 itself is still controversial and though the majority of therapy studies still reports on an extraordinary good prognosis of TEL/AML1 þ patients, interestingly, those trials with large sample sizes and an adequate long-term follow-up found similar incidence rates of TEL/AML1 þ cases at initial diagnosis and relapse.…”

Section: Discussionsupporting

confidence: 60%

“…However, the prognostic relevance of TEL/AML1 itself is still controversial and though the majority of therapy studies still reports on an extraordinary good prognosis of TEL/AML1 þ patients, interestingly, those trials with large sample sizes and an adequate long-term follow-up found similar incidence rates of TEL/AML1 þ cases at initial diagnosis and relapse. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] We showed that with an excellent 90% 5-year EFS estimate, TEL/AML1 þ patients fared significantly better than TEL/AML1À patients, and that with an incidence of 14% among the relapsed BCP ALL study population, the prevalence rate of TEL/AML1 was clearly inferior as compared to the time point of primary diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9][10][11][12][13] Based on event-free survival (EFS) rates between 90 and 100%, it was originally believed that this rearrangement is a rather favorable prognostic indicator in B-cell precursor (BCP) ALL. [3][4][5][6][8][9][10][11][12][13] However, this notion was subsequently disputed by others as they found a similar incidence of TEL/AML1 þ cases at initial diagnosis and relapse. 7,9,14,15 Since the median onset of TEL/AML1 þ relapses occurs comparatively late, some of the discrepant incidence rates of relapses in TEL/AML1 þ leukemia may result from different sample sizes and clinical follow-up times.…”

Section: Introductionmentioning

confidence: 99%

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Incidence and relevance of secondary chromosome abnormalities in childhood TEL/AML1+ acute lymphoblastic leukemia: an interphase FISH analysis

Attarbaschi

Mann

König³

et al. 2004

Leukemia

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The aim of the present study was to determine the frequency and clinical relevance of the most common secondary karyotype abnormalities in TEL/AML1 þ B-cell precursor acute lymphoblastic leukemia (ALL) as assessed with fluorescence in situ hybridization (FISH) analyses. Screening of 372 patients who were enrolled in two consecutive Austrian childhood ALL multicenter trials identified 94 (25%) TEL/AML1 þ cases. TEL deletions, trisomy 21 and an additional der(21)t(12;21) were detected in 52 (55%), 13 (14%) and 14 (15%) TEL/AML1 þ patients, respectively. The 12p aberrations (P ¼ 0.001) and near tetraploidy (P ¼ 0.045) were more common in TEL/AML1 þ patients, whereas the incidence of diploidy, pseudodiploidy, hypodiploidy, low hyperdiploidy, near triploidy, del(6q), chromosome 9 and 11q23 abnormalities was similar among TEL/ AML1 þ and TEL/AML1À patients. None of the TEL/AML1 þ patients had a high hyperdiploid karyotype. Univariate analysis indicated that among TEL/AML1 þ patients those with a deletion of the nontranslocated TEL allele had a worse prognosis than those without this abnormality (P ¼ 0.034). We concluded that the type and incidence of the most common secondary aberrations in TEL/AML1 þ ALL can be conveniently identified with little additional effort during interphase screening with appropriate TEL and AML1 FISH probes. We also provided preliminary evidence that the deletion of the nontranslocated TEL allele may adversely influence the clinical course of TEL/AML1 þ ALL.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Incidence and relevance of secondary chromosome abnormalities in childhood TEL/AML1+ acute lymphoblastic leukemia: an interphase FISH analysis

Attarbaschi

Mann

König³

et al. 2004

Leukemia

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“…Several studies have analyzed the clinical and biological features in ALL patients carrying the translocation t(12;21) leading to the TEL-AML1 gene fusion. [27][28][29][30][31][32][33][34][35][36][37][38] None of those studies reported a low Hb level to be associated with TEL-AML1. One study addressed this issue, but failed to demonstrate a correlation between Hb and TEL-AML1, probably due to the limited number of patients analyzed (11/51 patients TEL-AML1 + ).…”

Section: Discussionmentioning

confidence: 99%

Anemia and survival in childhood acute lymphoblastic leukemia

Teuffel¹,

Stanulla²,

Cario³

et al. 2008

Haematologica

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“…Although, global frequency of TEL-AML1 positivity has been reported to be 20-30% in pediatric ALL (Hong et al, 2008), some authors have reported very lower frequencies of TEL-AML1in some geographical regions (Kwong and Wong, 1997;Eguchi-Ishimae et al, 1998;Garcia-Sanz et al, 1999;Tsang et al, 2001;Rahman et al, 2006;Chung et al, 2010;Mazloumi et al, 2012) including one study from a single centre at Lahore, Punjab, Pakistan indicating 6% (3/50) frequency of TEL-AML1 (Faiz and Qazi, 2010), while others have reported frequency of this gene to be at other single Centres to be about 16% (Iqbal et al, 2007;Sabir et al, 2012). However, all of these studies were carried out at single centre or locations in Pakistan and therefore does not provide a comprehensive view of TEL-AML1 frequency in Pakistani population.…”

Section: Molecular Genetic Studies On 167 Pediatric All Patients Frommentioning

confidence: 99%

Molecular Genetic Studies on 167 Pediatric ALL Patients from Different Areas of Pakistan Confirm a Low Frequency of the Favorable Prognosis Fusion Oncogene TEL-AML1 (t 12; 21) in Underdeveloped Countries of the Region

Iqbal

2014

Asian Pacific Journal of Cancer Prevention

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TEL-AML1 fusion oncogene (t 12; 21) is the most common chromosomal abnormality in childhood acute lymphoblastic leukemia (ALL). This translocation is associated with a good prognosis and rarely shows chemotherapeutic resistance to 3-drug based remission induction phase of treatment as well as overall treatment. Thus, the higher the frequency of this fusion oncogene, the easier to manage childhood ALL in a given region with less intensive chemotherapy. Although global frequency of TEL-AML1 has been reported to be 20-30%, a very low frequency has been found in some geographical regions, including one study from Lahore, Punjab, Pakistan and others from India. The objective of present study was to investigate if this low frequency of TEL-AML1 in pediatric ALL is only in Lahore region or similar situation exists at other representative oncology centers of Pakistan. A total of 167 pediatric ALL patients were recruited from major pediatric oncology centers situated in Lahore, Faisalabad, Peshawar and Islamabad. Patients were tested for TEL-AML1 using nested reverse transcription polymerase chain reaction (RT-PCR). Only 17 out of 167 (10.2%) patients were found to be TEL-AML1 positive. TEL-AML1+ALL patients had favorable prognosis, most of them (82.4%, 14/17) showing early remission and good overall survival. Thus, our findings indicate an overall low frequency of TEL-AML1 in Pakistan pediatric ALL patients, in accordance with lower representation of this prognostically important genetic abnormality in other less developed countries, specifically in south Asia, thus associating it with poor living standards in these ethnic groups. It also indicates ethnic and geographical differences in the distribution of this prognostically important genetic abnormality among childhood ALL patients, which may have a significant bearing on ALL management strategies in different parts of the world.

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TEL/AML1 rearrangement and the prognostic significance in childhood acute lymphoblastic leukemia in Hong Kong

Abstract: The TEL/AML1 rearrangement has been implicated as an independent good prognostic factor in pediatric acute lymphoblastic leukemia (ALL). We examined TEL/AML1 using nested reverse-transcription polymerase chain reaction (

Cited by 41 publications

References 35 publications

Incidence and relevance of secondary chromosome abnormalities in childhood TEL/AML1+ acute lymphoblastic leukemia: an interphase FISH analysis

Incidence and relevance of secondary chromosome abnormalities in childhood TEL/AML1+ acute lymphoblastic leukemia: an interphase FISH analysis

Anemia and survival in childhood acute lymphoblastic leukemia

Molecular Genetic Studies on 167 Pediatric ALL Patients from Different Areas of Pakistan Confirm a Low Frequency of the Favorable Prognosis Fusion Oncogene TEL-AML1 (t 12; 21) in Underdeveloped Countries of the Region

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