Molecular delineation, expression profiling, immune response, and anti-apoptotic function of a novel clusterin homolog from big-belly seahorse (Hippocampus abdominalis)

Effect of Seahorse Extract (Hippocampus comes L.) on Caspase-3 and TUNEL assay in Rats After Depot Medroxyprogesterone Acetate Induction

“…21 Wijerathna et al, reported the role of glycoprotein in Hippocampus abdominalis have effects on anti-apoptotic on oxidative stress induced cell death. 22 The other result stated by Qian et al, useful the Hippocampus kuda Bleeler that hydrolysate increased the mitochondrial membrane potential and reduced DNA damage. 24 But, there is no reports about the Hippocampus comes L., influence the germ cell apoptotic.…”

Chemical constituents, pharmacological activities and quality evaluation methods of genus Hippocampus: A comprehensive review

“…Clusterin (CLU) is a glycoprotein that functions in different cell signaling pathways that are associated with various diseases. Wijerathna et al (2022) investigate the bioactivity of CLU from H. abdominalis (HaCLU) on oxidative stress-induced cell death. The study found that HaCLU has anti-apoptotic function, inhibiting H 2 O 2 -induced oxidative stress and subsequent cell death.…”

“…It is known as ‘South ginseng’ in traditional Chinese medicine (TCM) culture. Pharmacological studies have shown that Hippocampus have anti-oxidation ( Chen et al, 2010 , Kim et al, 2019 , Zheng et al, 2012 ), anti-inflammation ( Chen et al, 2015 , Tharuka et al, 2019 , Wu et al, 2020 ), anti-depressant ( Li et al, 2020 ), anti-hypertension ( Je et al, 2020 ), anti-prostatic hyperplasia ( Xu et al, 2014 ), anti-virus ( Sandamalika et al, 2021 , Tharuka et al, 2019 , Udayantha et al, 2021 ), anti-apoptotic ( Kodagoda et al, 2022 , Sellaththurai et al, 2020 , Wijerathna et al, 2022 ), anti-fatigue ( Guo et al, 2017 , Zhang et al, 2019 ), and other functions ( Pangestuti et al, 2013 , Sellaththurai et al, 2020 , Yuan et al, 2018 ). And those pharmacological action are mainly related to their active ingredients, including amino acids ( Ge et al, 2019 , Sari et al, 2017 , Zhao, 2018 ), abundant proteins (peptides and oligopeptides) ( Je et al, 2020 , Pangestuti et al, 2013 ), fatty acids ( Huang & Xu, 2016 , Shen et al, 2016 , Su & Xu, 2015 ), nucleosides ( Wei et al, 2015 , Zhao et al, 2011 ), steroids ( Wu et al, 2017 , Zhao, 2018 ), and other small molecular compounds ( Si et al, 2018 , Zhao, 2018 ).…”

Genome rearrangements, male pregnancy and immunological tolerance – the curious case of the syngnathid immune system

“…The major immune organ and the first to develop in syngnathids is the head kidney (Tort et al, 2003;Falk-Petersen, 2005). Splenic presence and functionality among syngnathids is largely unsubstantiated with no spleen identifications in pipefish, while in seahorses its presence is contentious, with a number of contrasting reports (Matsunaga and Rahman, 1998;Novelli et al, 2015;Luo et al, 2016;Ofelio et al, 2018;Wijerathna et al, 2022). In seahorses, developmental studies report the presence of a spleen during early juvenile development (Novelli et al, 2015;Ofelio et al, 2018), but adult spleens are seldom reported.…”