Molecular cytogenetic findings of acute leukemia included in the Brazilian Collaborative Study Group of Infant acute leukemia

Emerenciano, Mariana; Arias, Diana Patricia Agudelo; Cóser, Virgínia Maria; Brito, Gilena Dantas de; Silva, Maria L. Macedo; Pombo‐de‐Oliveira, Maria S.

doi:10.1002/pbc.20654

Cited by 28 publications

(25 citation statements)

References 25 publications

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“…The most common genetic events occurring in children younger than 12 months, both in ALL and AML, are the rearrangements of the MLL gene on chromosome 11q23, which may be as high as 85% depending on the techniques applied (10,11). Infants diagnosed with acute leukemia harboring an 11q23 rearrangement have a particularly poor prognosis when compared to other children with acute leukemia (12).…”

Section: Clinical Characterizationmentioning

confidence: 99%

“…For example, MLL rearrangement is associated with 90% of CD10 -cases but only with 20% of CD10 + cases. Also, the younger the child the higher is the frequency of MLL translocations (10,13). In series of IAL cases from different regions of Brazil, the comparison between age, immunophenotyping, and MLL rearrangements demonstrated that up to 14 months of age the pro-B subtype and the MLL-positive cases predominated (P < 0.0001), and among older cases, most of them were c-ALL and MLL-negative cases, as shown in Figure 1.…”

Section: Clinical Characterizationmentioning

confidence: 99%

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Acute leukemia in early childhood

Emerenciano

Koifman

Pombo‐de‐Oliveira

2007

Braz J Med Biol Res

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Acute leukemia in early childhood is biologically and clinically distinct. The particular characteristics of this malignancy diagnosed during the first months of life have provided remarkable insights into the etiology of the disease. The pro-B, CD10 negative immunophenotype is typically found in infant acute leukemia, and the most common genetic alterations are the rearrangements of the MLL gene. In addition, the TEL /AML1 fusion gene is most frequently found in children older than 24 months. A molecular study on a Brazilian cohort (age range 0-23 months) has detected TEL /AML1 +ve (N = 9), E2A/PBX1 +ve (N = 4), PML /RARA +ve (N = 4), and AML1/ETO +ve (N = 2) cases. Undoubtedly, the great majority of genetic events occurring in these patients arise prenatally. The environmental exposure to damaging agents that give rise to genetic changes prenatally may be accurately determined in infants since the window of exposure is limited and known. Several studies have shown maternal exposures that may give rise to leukemogenic changes. The Brazilian Collaborative Study Group of Infant Acute Leukemia has found that mothers exposed to dipyrone, pesticides and hormones had an increased chance to give birth to babies with infant acute leukemia [OR = 1.48 (95%CI = 1.05-2.07), OR = 2.27 (95%CI = 1.56-3.31) and OR = 9.08 (95%CI = 2.95-27.96)], respectively. This review aims to summarize recent clues that have facilitated the elucidation of the biology of early childhood leukemias, with emphasis on infant acute leukemia in the Brazilian population.

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Section: Clinical Characterizationmentioning

confidence: 99%

Section: Clinical Characterizationmentioning

confidence: 99%

Acute leukemia in early childhood

Emerenciano

Koifman

Pombo‐de‐Oliveira

2007

Braz J Med Biol Res

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“…The numbers of the main clinical and laboratory data were same as described previously (Emerenciano et al, 2006), but eight AML cases were excluded due to lack of birth weight records. Eight cases, which were misclassified in the previous report as biphenotypic leukaemia with aberrant phenotype, were then categorized as ALL in the present analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Details regarding case definition, control selection, exclusion criteria and data collection have been published previously (Emerenciano et al, 2006;Pombo-de-Oliveira et al, 2006).…”

Section: Methodsmentioning

confidence: 99%

High birth weight as an important risk factor for infant leukemia

Koifman

Pombo‐de‐Oliveira

2008

Br J Cancer

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In this paper, we compared the birth weight distribution among 201 infant leukaemia (IL) cases with that of 440 noncancer controls enrolled in Brazil in 1999–2005. Compared with the general population and the stratum 2500–2999 g as reference, IL cases weighing 3000–3999 g presented an odds ratio (OR) of 1.68 (95% CI: 1.03–2.76), and those of 4000 g or more, an OR of 2.28 (95% CI: 1.08–4.75), P trend <0.01. Using hospital-based controls, the OR for 4000 g or more, compared to 2500–2999 g, was 1.30 (95% CI: 1.02–1.43) after adjusting for confounders (gender, income, maternal age, pesticide and hormonal exposure during pregnancy). The results suggest that high birth weight is associated with increased risk of IL.

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“…The presence of the fusion genes MLL/AF4, MLL/AF9 and MLL/ENL was assessed by RT-PCR, using conditions (Emerenciano et al 2006) and primers (Andersson et al 2001) previously described. Cell lines and known positive patients' samples were used as positive controls.…”

Section: Molecular Analysismentioning

confidence: 99%

Occurrence of Acute Myeloid Leukemia in Young Pregnant Women

Menezes

Emerenciano

Pimenta

et al. 2008

Clinical medicine. Blood disorders

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Abstract:Although acute leukaemia is rare in pregnancy its importance lies in its life-threatening potential, both to the child and the mother. The possibility of vertical transmission of leukemic cells increases the attention devoted to these patients and their offspring. Three cases of pregnant young women (15-17 years of age) with AML are presented. This series of cases is the fi rst report where gene abnormalities such as ITD mutations of the FLT3 gene and AML1/ETO fusion genes were screened in pregnant AML patients and their babies, so far. Unfortunately, very poor outcomes have been associated to similar cases described in literature, and the same was true to the patients described herein. Although very speculative, we think that the timing and possible similar exposures would be involved in all cases.

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Molecular cytogenetic findings of acute leukemia included in the Brazilian Collaborative Study Group of Infant acute leukemia

Abstract: Our results show that not only MLL rearrangements, but also other molecular abnormalities occur before birth and may contribute to leukemogenesis.

Cited by 28 publications

References 25 publications

Acute leukemia in early childhood

Acute leukemia in early childhood

High birth weight as an important risk factor for infant leukemia

Occurrence of Acute Myeloid Leukemia in Young Pregnant Women

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