2017
DOI: 10.1155/2017/4723193
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Abstract: Over the past few years, noncoding RNAs (ncRNAs) have been extensively studied because of the significant biological roles that they play in regulation of cellular mechanisms. ncRNAs are associated to higher eukaryotes complexity; accordingly, their dysfunction results in pathological phenotypes, including cancer. To date, most research efforts have been mainly focused on how ncRNAs could modulate the expression of protein-coding genes in pathological phenotypes. However, recent evidence has shown the existenc… Show more

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Cited by 33 publications
(33 citation statements)
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References 173 publications
(202 reference statements)
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“…No information is available on PDC-AS1 (PDC antisense RNA 1), but the function of its sense transcript PDC (phosducin) has been described. The exact function of antisense transcripts has not been elucidated, but evidence suggests the existence of a mutual post-transcriptional regulation involving sense and antisense transcripts [ 33 ]. PDC , encoding a phosphoprotein involved in the process of vision in the retina, has been associated with stress-induced hypertension [ 34 , 35 ].…”
Section: Discussionmentioning
confidence: 99%
“…No information is available on PDC-AS1 (PDC antisense RNA 1), but the function of its sense transcript PDC (phosducin) has been described. The exact function of antisense transcripts has not been elucidated, but evidence suggests the existence of a mutual post-transcriptional regulation involving sense and antisense transcripts [ 33 ]. PDC , encoding a phosphoprotein involved in the process of vision in the retina, has been associated with stress-induced hypertension [ 34 , 35 ].…”
Section: Discussionmentioning
confidence: 99%
“… 4 , 7 Moreover, lncRNAs could directly bind the 3′-UTR of mRNAs, protecting them against miRNA-induced degradation. 8 …”
Section: Introductionmentioning
confidence: 99%
“…It means that they can act as a negative regulation of miRNAs by competing, using their binding sites, with the miRNA–mRNA target interaction. Their important role in gene regulation is demonstrated by some papers, which show that deregulation of circRNAs is associated in different types of cancer [ 15 ].…”
Section: Introductionmentioning
confidence: 99%