Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system

Merlio, Jean-Philippe; Ernfors, Patrik; Jaber, Mohamed; Persson, Håkan

doi:10.1016/0306-4522(92)90292-a

Cited by 574 publications

(340 citation statements)

References 89 publications

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“…Further evidence supporting a physiological role of BDNF for serotonergic neurons are the presence of BDNF displaceable binding sites and trkB mRNA (Merlio et al, 1992) in the dorsal raphe nucleus, the retrograde transport of BDNF from 5-HT terminal fields in cortex to cell bodies in the raphe nuclei (Anderson et al, 1995) and the in viva regulation of serotonergic metabolism and function by BDNF Martin-Iverson et al, 1994;Siuciak et al, 1994). Thus, exogenous BDNF appears to be capable of augmenting functional as well as structural aspects of serotonergic neurons.…”

Section: Discussionmentioning

confidence: 97%

“…Several recent in vivo studies suggest that some members of the neurotrophin family have functional influences upon serotonergic neurons in the brain. High-affinity binding sites for Iz51-NT-3 and mRNA transcripts for trkB and trkC, the signal-transducing receptors for BDNF and NT-3, respectively (Merlio et al, 1992) are found in the dorsal raphe nucleus. Moreover, BDNF is retrogradely transported from 5-HT terminal fields in the striatum and hippocampus to cell bodies in the raphe nuclei (Anderson et al, 1995).…”

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confidence: 99%

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Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain

et al. 1995

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A pathology of brain serotonergic (5-HT) systems has been found in psychiatric disturbances, normal aging and in neurodegenerative disorders including Alzheimer's and Parkinson's disease. Despite the clinical importance of 5-HT, little is known about the endogenous factors that have neurotrophic influences upon 5-HT neurons. The present study examined whether chronic pain parenchymal administration of the neurotrophins brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) or NGF could prevent the severe degenerative loss of serotonergic axons normally caused by the selective 5-HT neurotoxin p-chloroamphetamine (PCA). The neurotrophins (5–12 micrograms/d) or the control substances (cytochrome c or PBS vehicle) were continuously infused into the rat frontoparietal cortex using an osmotic minipump. One week later, rats were subcutaneously administered PCA (10 mg/kg) or vehicle, and the 5-HT innervation was evaluated after two more weeks of neurotrophin infusion. As revealed with 5-HT immunocytochemistry, BDNF infusions into the neocortex of intact (non-PCA-lesioned) rats caused a substantial increase in 5-HT axon density in a 3 mm diameter region surrounding the cannula tip. In PCA-lesioned rats, intracortical infusions of BDNF completely prevented the severe neurotoxin-induced loss of 5-HT axons near the infusion cannula. In contrast, cortical infusions of vehicle or the control protein cytochrome c did not alter the density of serotonergic axons in intact animals, nor did control infusions prevent the loss of 5-HT axons in PCA-treated rats. NT-3 caused only a modest sparing of the 5-HT innervation in PCA-treated rats, and NGF failed to prevent the loss of 5-HT axon density. The immunocytochemical data were supported by neurochemical evaluations which showed that BDNF attenuated the PCA-induced loss of 5-HT and 5- HIAA contents and 3H-5-HT uptake near the infusion cannula. Thus, BDNF can promote the sprouting of mature, uninjured serotonergic axons and dramatically enhance the survival or sprouting of 5-HT axons normally damaged by the serotonergic neurotoxin PCA.

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Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 99%

Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain

et al. 1995

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“…BDNF and its receptor TrkB are co-expressed in serotonergic neurons within the dorsal raphe and median raphe (Merlio et al, 1992;Madhav et al, 2001), and BDNF is retrogradely transported from 5-HT terminals in the striatum and hippocampus to cell bodies in the raphe nuclei (Anderson et al, 1995). BDNF has been shown to promote the survival and morphological differentiation of 5-HT neurons both in culture and in vivo.…”

Section: Bdnf Regulation Of 5-ht Neuron Development and Functionsmentioning

confidence: 99%

Interaction between BDNF and Serotonin: Role in Mood Disorders

Martinowich

2007

Neuropsychopharmacol

675

458

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Brain-derived neurotrophic factor (BDNF) and serotonin (5-hydroxytryptamine, 5-HT) are two seemingly distinct signaling systems that play regulatory roles in many neuronal functions including survival, neurogenesis, and synaptic plasticity. A common feature of the two systems is their ability to regulate the development and plasticity of neural circuits involved in mood disorders such as depression and anxiety. BDNF promotes the survival and differentiation of 5-HT neurons. Conversely, administration of antidepressant selective serotonin reuptake inhibitors (SSRIs) enhances BDNF gene expression. There is also evidence for synergism between the two systems in affective behaviors and genetic epitasis between BDNF and the serotonin transporter genes.

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“…In addition to the classic neurotransmitters, the perirhinal cortex is also capable of signalling via the neurotrophins and their receptors (Sobreviela et al, 1996). Although there are low levels of nerve growth factor (NGF) and TrkA present in the neocortex (Altar et al, 1991;Merlio et al, 1992), the other neurotrophins and their receptors are more widely expressed throughout the neocortex (Klein et al, 1990;Merlio et al, 1992;Altar et al, 1994). However, the parahippocampal region shows higher levels of neurotrophins compared to rest of the neocortex: NGF (Lin et al, 1996;Conti et al, 2009), brain-derived neurotrophic factor (BDNF, Sato et al, 1996;Vezzani et al, 1999;Engler-Chiurazzi et al, in press), NT-3 (Eagleson et al, 2001) and all three Trk receptors (Bengzon et al, 1993) have been shown to be strongly expressed in the perirhinal cortex.…”

Section: Neurotransmission In the Perirhinal Cortexmentioning

confidence: 99%

The rat perirhinal cortex: A review of anatomy, physiology, plasticity, and function

Kealy

Commins

2011

Progress in Neurobiology

105

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Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system

Cited by 574 publications

References 89 publications

Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain

Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain

Interaction between BDNF and Serotonin: Role in Mood Disorders

The rat perirhinal cortex: A review of anatomy, physiology, plasticity, and function

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