Molecular cloning of complementary DNA for a novel human hepatoma-derived growth factor. Its homology with high mobility group-1 protein.

Nakamura, Haruki; Izumoto, Yoshitaka; Kambe, Hiroshi; Kuroda, Toshifumi; Mori, Tetsuji; Kawamura, Kazuo; Yamamoto, Hiroyasu; Kishimoto, Tadamitsu

doi:10.1016/s0021-9258(17)31509-0

Cited by 169 publications

(19 citation statements)

References 35 publications

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“…Of interest, in this larger and pathologically more diversified cohort, we found HDGF was significantly associated with PoPH. Given HDGF is highly expressed in the liver and functions as an angiogenesis factor, 25,26 it is intriguing that HDGF may play a direct role in PoPH development and disease progression. Portal hypertension hepatic dysfunction is associated with an altered circulation of vasoreactive mediators which contribute to abnormal vascular remodeling and eventually lead to PAH 27–30 .…”

Section: Discussionmentioning

confidence: 99%

Hepatoma‐derived growth factor is associated with pulmonary vascular remodeling and PAH disease severity and survival

et al. 2022

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Hepatoma‐derived growth factor (HDGF) was previously shown to be associated with increased mortality in a small study of idiopathic and connective tissue disease‐associated pulmonary arterial hypertension (PAH). In this study, we measured serum HDGF levels in a large multicenter cohort (total 2017 adult PAH‐Biobank enrollees), we analyzed the associations between HDGF levels and various clinical measures using linear or logistic regression models. Higher HDGF levels were found to be significantly associated with worse pulmonary hemodynamics, prostacyclin treatment; among PAH subtypes, higher HDGF levels were most associated with portopulmonary hypertension (beta = 0.469, p < 0.0001). Both Kaplan–Meier curve and Cox proportional hazard regression demonstrated that higher HDGF levels are associated with a higher risk of mortality (COX hazard ratio 1.31, p < 0.0001). Further, in the Sugen hypoxia (SuHx) rat model, the highest HDGF levels were post‐pulmonary circulation, and HDGF levels significantly increased with the development of PAH. In pulmonary arteries, immunohistochemistry staining showed that HDGF was highly expressed in pulmonary smooth muscle cells in both PAH patients and SuHx rats. In conclusion, we found that higher serum HDGF was linked with increased mortality, and associated with disease severity in a large multi‐center adult PAH cohort (n = 2017). In the SuHX PAH models, circulating HDGF levels are pulmonary in origin and increase with PAH progression. HDGF may be actively involved in vascular remodeling in PAH.

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Section: Discussionmentioning

confidence: 99%

Hepatoma‐derived growth factor is associated with pulmonary vascular remodeling and PAH disease severity and survival

et al. 2022

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“…Additionally, we studied the regulation mechanism of CCNI2 on gastric cancer and found that HDGF may be the downstream of CCNI2. Transcription factor hepatoma-derived growth factor (HDGF) is an acidic heparin-binding growth factor, originally isolated from the culture medium of human hepatocellular carcinoma cell line HuH-7 [ 33 ]. Previous studies have shown that HDGF can be translocated into the nucleus and act as a direct DNA-binding protein, possibly as both cytokine and transcription factor [ 34 – 37 ].…”

Section: Discussionmentioning

confidence: 99%

CCNI2 promotes the progression of human gastric cancer through HDGF

Chen

Zhou

et al. 2021

Cancer Cell Int

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Background Gastric cancer is a highly aggressive malignant tumor with heterogeneity and is still a global health problem. The present study aimed to investigate the role of Cyclin I-like (CCNI2) in the regulation of phenotype and tumorigenesis, as well as its underlying mechanisms. Method The expression profile of CCNI2 in gastric cancer was determined based on The Cancer Genome Atlas (TCGA) database and immunohistochemical staining. The effects of altered CCNI2 expression on the biological phenotypes such as proliferation, clone formation, apoptosis and migration of gastric cancer cell lines BGC-823 and SGC-7901 were investigated. Mice xenograft models were established to reveal the role of CCNI2 knockdown on tumorigenesis. The potential mechanism of CCNI2 regulating gastric cancer was preliminarily determined by RNA sequencing. Result CCNI2 was abundantly expressed in gastric cancer and was positively correlated with pathological stage. Knockdown of CCNI2 slowed down the malignant progression of gastric cancer by inhibiting tumor cell proliferation, increasing the susceptibility to apoptosis and suppressing migration. Moreover, downregulation of CCNI2 attenuated the ability of gastric cancer cells to form tumors in mice. Additionally, there was an interaction between CCNI2 and transcription factor hepatoma-derived growth factor (HDGF) in SGC-7901 cells. Knockdown of CCNI2 alleviated the promoting effects of HDGF overexpression in gastric cancer cells. Conclusions CCNI2 promoted the progression of human gastric cancer through HDGF, which drew further interest regarding its clinical application as a potential therapeutic target.

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“…HDGF, isolated from the conditioned medium of cultures of human hepatocellular carcinoma cell line Huh-7, is an acidic heparin-binding growth factor [ 88 ]. The human HGDF protein comprises 240 amino acids with a bipartite nuclear localization motif [ 89 , 90 ] and a PWWP domain [ 91 , 92 ].…”

Section: Gastric Organoid Culture Systems and Microenvironmentsmentioning

confidence: 99%

Generation of Human Stomach Cancer iPSC-Derived Organoids Induced by Helicobacter pylori Infection and Their Application to Gastric Cancer Research

Wuputra

Pan

et al. 2022

Cells

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There is considerable cellular diversity in the human stomach, which has helped to clarify cell plasticity in normal development and tumorigenesis. Thus, the stomach is an interesting model for understanding cellular plasticity and for developing prospective anticancer therapeutic agents. However, many questions remain regarding the development of cancers in vivo and in vitro in two- or three-dimensional (2D/3D) cultures, as well as the role of Helicobacter pylori (H. p.) infection. Here, we focus on the characteristics of cancer stem cells and their derived 3D organoids in culture, including the formation of stem cell niches. We define the conditions required for such organoid culture in vitro and examine the ability of such models for testing the use of anticancer agents. We also summarize the signaling cascades and the specific markers of stomach-cancer-derived organoids induced by H. p. infection, and their stem cell niches.

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Molecular cloning of complementary DNA for a novel human hepatoma-derived growth factor. Its homology with high mobility group-1 protein.

Cited by 169 publications

References 35 publications

Hepatoma‐derived growth factor is associated with pulmonary vascular remodeling and PAH disease severity and survival

Hepatoma‐derived growth factor is associated with pulmonary vascular remodeling and PAH disease severity and survival

CCNI2 promotes the progression of human gastric cancer through HDGF

Generation of Human Stomach Cancer iPSC-Derived Organoids Induced by Helicobacter pylori Infection and Their Application to Gastric Cancer Research

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