Molecular cloning and variant analysis of the
            <i>TSHR</i>
            gene in goose (
            <i>Anser cygnoides</i>
            )

Wang, C; Liu, Y; Li, G; Gong, Shaoming; Yang, Yu; Wang, H; He, Daqian

doi:10.1080/00071668.2020.1751803

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…The same selection targets have been described in chicken [ 62 ]. Previous studies have established a pivotal role for TSHR in metabolic regulation and photoperiod control during reproduction in animals, such as sheep [ 63 ], herrings [ 64 ], geese [ 65 ], chickens [ 66 ], and rabbits [ 67 ]. In addition, an SNP in the TSHR gene resulted in an aspartic acid-to-alanine substitution, and it was conserved among most of the other species.…”

Section: Discussionmentioning

confidence: 99%

Whole-genome resequencing of Chinese indigenous sheep provides insight into the genetic basis underlying climate adaptation

Jin,

Wang,

Liu

et al. 2024

Genet Sel Evol

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Background Chinese indigenous sheep are valuable resources with unique features and characteristics. They are distributed across regions with different climates in mainland China; however, few reports have analyzed the environmental adaptability of sheep based on their genome. We examined the variants and signatures of selection involved in adaptation to extreme humidity, altitude, and temperature conditions in 173 sheep genomes from 41 phenotypically and geographically representative Chinese indigenous sheep breeds to characterize the genetic basis underlying environmental adaptation in these populations. Results Based on the analysis of population structure, we inferred that Chinese indigenous sheep are divided into four groups: Kazakh (KAZ), Mongolian (MON), Tibetan (TIB), and Yunnan (YUN). We also detected a set of candidate genes that are relevant to adaptation to extreme environmental conditions, such as drought-prone regions (TBXT, TG, and HOXA1), high-altitude regions (DYSF, EPAS1, JAZF1, PDGFD, and NF1) and warm-temperature regions (TSHR, ABCD4, and TEX11). Among all these candidate genes, eight ABCD4, CNTN4, DOCK10, LOC105608545, LOC121816479, SEM3A, SVIL, and TSHR overlap between extreme environmental conditions. The TSHR gene shows a strong signature for positive selection in the warm-temperature group and harbors a single nucleotide polymorphism (SNP) missense mutation located between positions 90,600,001 and 90,650,001 on chromosome 7, which leads to a change in the protein structure of TSHR and influences its stability. Conclusions Analysis of the signatures of selection uncovered genes that are likely related to environmental adaptation and a SNP missense mutation in the TSHR gene that affects the protein structure and stability. It also provides information on the evolution of the phylogeographic structure of Chinese indigenous sheep populations. These results provide important genetic resources for future breeding studies and new perspectives on how animals can adapt to climate change.

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Section: Discussionmentioning

confidence: 99%

Whole-genome resequencing of Chinese indigenous sheep provides insight into the genetic basis underlying climate adaptation

Jin,

Wang,

Liu

et al. 2024

Genet Sel Evol

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“…CAMK4 is a candidate domestication gene locus, associated with a wide range of traits (morphology, immunity, reproductive or production traits) in sheep ( 47 ). It has long been shown that thyroid-stimulating hormone receptor (TSHR) is associated with reproduction and plays an important role in metabolic regulation and photoperiodic control during reproduction in birds and mammals ( 48 , 49 ). Furthermore, 29 bp nucleotide sequence variation within the TSHR was significantly associated with litter size in sheep.…”

Section: Discussionmentioning

confidence: 99%

Photoperiods induced the circRNA differential expression in the thyroid gland of OVX+E2 ewes

Wang

et al. 2022

Front. Endocrinol.

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Circular RNAs (circRNAs) are non-coding RNAs newly identified and play important roles in RNA regulation. However, little is known regarding photoperiods induced circRNAs in the thyroid gland. In this study, we performed a comprehensive analysis of circRNA profiles in the thyroid gland of OVX+E2 ewes at different photoperiods by whole transcriptome sequencing. A total of 37,470 novel circRNAs were detected in different photoperiods (42 days of short photoperiod treatment, SP42; 42 days of long photoperiod treatment, LP42; SP42 transfer to LP42, SPLP42), with a total of 817 circRNAs for SP42-LP42 (down: 132; up: 114), LP42-SPLP42 (down: 136; up: 112) and SP42-SPLP42 (down: 182; up: 141) having differentially expressed. Functional enrichment annotation analysis of DE-circRNAs for GO and KEGG by R package, features that influence photoperiod response in Sunite ewes through the Inositol phosphate metabolism, cGMP-PKG signaling pathway, Calcium signaling pathway, MAPK signaling pathway, and Oocyte meiosis. In addition, competitive endogenous RNA (ceRNA) network analysis revealed target binding sites for identified miRNAs in DE-cirRNAs such as oar-miR-10b, oar-miR-200c, oar-miR-21, oar-miR-370-3p, oar-miR-377-3p, oar-miR-181a, oar-miR-432, and oar-miR-495-3p. These results of this study will provide some new information for understanding circRNA function as well as the changes in the sheep thyroid gland under different photoperiods.

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Screen of small fragment mutations within the sheep thyroid stimulating hormone receptor gene associated with litter size

Zhou

Pan

et al. 2021

Animal Biotechnology

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Molecular cloning and variant analysis of the TSHR gene in goose ( Anser cygnoides )

Cited by 3 publications

References 19 publications

Whole-genome resequencing of Chinese indigenous sheep provides insight into the genetic basis underlying climate adaptation

Whole-genome resequencing of Chinese indigenous sheep provides insight into the genetic basis underlying climate adaptation

Photoperiods induced the circRNA differential expression in the thyroid gland of OVX+E2 ewes

Screen of small fragment mutations within the sheep thyroid stimulating hormone receptor gene associated with litter size

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