Molecular cloning and characterization of a defective recombinant feline leukaemia virus associated with myeloid leukaemia

Tzavaras, Theodore; Stewart, Monica; McDougall, Ann; Fulton, Ruth; Testa, Nydia G; Onions, David; Neil, James C.

doi:10.1099/0022-1317-71-2-343

Cited by 39 publications

(31 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mechanisms for production of PERV-A/C in vivo might include recombination between two endogenous PERV loci that are independently replication defective (3,4), recombination of a replication-competent endogenous virus with a defective endogenous locus, or the recombination of defective endogenous loci with replication-competent exogenous PERV. Support for the latter mechanism can be taken from analogy to the formation of mink cell focus-forming viruses in mice (7) as well as from the exogenous B subgroup of feline leukemia virus (FeLV-B) (1,30,32). Xenotropic FeLV-B is generated via the recombination of exogenous ecotropic virus (FeLV-A) with defective endogenous FeLV-related sequences, and as a result, FeLV-B is only found associated with cats infected with FeLV-A.…”

Section: Discussionmentioning

confidence: 99%

Identification of Exogenous Forms of Human-Tropic Porcine Endogenous Retrovirus in Miniature Swine

Wood¹,

Quinn²,

Suling³

et al. 2004

J Virol

130

149

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Identification of Exogenous Forms of Human-Tropic Porcine Endogenous Retrovirus in Miniature Swine

Wood¹,

Quinn²,

Suling³

et al. 2004

J Virol

130

149

View full text Add to dashboard Cite

show abstract

“…FeLV and FIV infections were evaluated through PCR as pre-viously published (Hohdatsu et al 1998, Miyazawa & Jarrett 1997, Tzavaras et al 1990 …”

Section: Methodsmentioning

confidence: 99%

Frequency and hematological alterations of different hemoplasma infections with retrovirusis co-infections in domestic cats from Brazil

et al. 2016

View full text Add to dashboard Cite

ABSTRACT.-Firmino F.P., Aquino L.C., Marçola T.G., Bittencourt M.V., Mycoplasma haemofelis is the agent of feline infectious anemia, although Candidatus M. haemominutum can also be associated. This study evaluated the frequency and hematological alterations caused by hemoplasma infections and co-infections with FeLV, FIV and Toxoplasma gondii in domestic cats from two distinct areas (urban -G1 and periurban -G2) of Brasília, Brazil. One hundred cats were evaluated, 51 from the G1 area and 49 from G2. No cats were positive for T. gondii. Hemoplasma infection was diagnosed in 33% cats from G1 and 32.6% from G2 (p>0.05). In G1 35.3% of the positive cats were infected with Mycoplasma haemofelis, 47.06% with Candidatus Mycoplasma haemominutum and 17.64% with mixed hemoplasma species infection; 12.5% of the cats identified as PCR positive in G2 were infected with Mycoplasma haemofelis, 18.75% with Candidatus Mycoplasma haemominutum and 68.75% with mixed infection. Cats from the periurban area had higher mixed hemoplasmas infection rates than those from urban area, and most of them were asymptomatic carriers. Cytology results were positive in only 5% of cats from G1. Mycoplasma haemofelis infected cats had normocytic normochromic anemia while the cats infected with Candidatus Mycoplasma haemominutum or with both species did not. 37.2% of G1 cats were co-infected with Mycoplasma haemofelis and FeLV, and presented lower PCV and hemoglobin concentration than those infected only with Mycoplasma haemofelis. The co--infection with Candidatus Mycoplasma haemominutum and FeLV produced lower WBC, segmented cells and platelets, and increased total protein concentration.

show abstract

“…Endogenous FeLV sequences do not by themselves produce infectious virus but readily recombine with exogenous feline leukemia viruses, notably in the env region that codes for the viral coat, producing recombinant viruses with altered biological activity and pathogenicity (4,17,21,43,44,51,53,54,60). For example, the recombinant subgroup C viruses have been found to induce aplastic anemia (18).…”

mentioning

confidence: 99%

“…Endogenous FeLVs are found in wild species of the genus Felis closely related to the domestic cat, although they are not present in species from other lineages within the Felidae (4, 56-58). Thus, enFeLVs are believed to have entered the germ line after the initial radiation of lineages in the cat family but before the radiation of domestic cat lineage species (3,23,25), although subsequent additional integrations into the germ line may also have occurred (50).Endogenous FeLV sequences do not by themselves produce infectious virus but readily recombine with exogenous feline leukemia viruses, notably in the env region that codes for the viral coat, producing recombinant viruses with altered biological activity and pathogenicity (4,17,21,43,44,51,53,54,60). For example, the recombinant subgroup C viruses have been found to induce aplastic anemia (18).…”

mentioning

confidence: 99%

Insertional Polymorphisms of Endogenous Feline Leukemia Viruses

Roca

Nash

Menninger

et al. 2005

J Virol

View full text Add to dashboard Cite

The number, chromosomal distribution, and insertional polymorphisms of endogenous feline leukemia viruses (enFeLVs) were determined in four domestic cats (Burmese, Egyptian Mau, Persian, and nonbreed) using fluorescent in situ hybridization and radiation hybrid mapping. Twenty-nine distinct enFeLV loci were detected across 12 of the 18 autosomes. Each cat carried enFeLV at only 9 to 16 of the loci, and many loci were heterozygous for presence of the provirus. Thus, an average of 19 autosomal copies of enFeLV were present per cat diploid genome. Only five of the autosomal enFeLV sites were present in all four cats, and at only one autosomal locus, B4q15, was enFeLV present in both homologues of all four cats. A single enFeLV occurred in the X chromosome of the Burmese cat, while three to five enFeLV proviruses occurred in each Y chromosome. The X chromosome and nine autosomal enFeLV loci were telomeric, suggesting that ectopic recombination between nonhomologous subtelomeres may contribute to enFeLV distribution. Since endogenous FeLVs may affect the infectiousness or pathogenicity of exogenous FeLVs, genomic variation in enFeLVs represents a candidate for genetic influences on FeLV leukemogenesis in cats.Endogenous feline leukemia virus (enFeLV) sequences are present in the genome of the domestic cat, Felis catus. They are homologous to exogenous feline leukemia viruses, which are oncogenic retroviruses capable of inducing both proliferative and degenerative diseases (15, 34). Whereas exogenous FeLVs are transmitted horizontally, endogenous feline leukemia proviruses are part of the germ line and are transmitted from parent to offspring as integral components of chromosomes (5,20). Endogenous FeLVs are found in wild species of the genus Felis closely related to the domestic cat, although they are not present in species from other lineages within the Felidae (4, 56-58). Thus, enFeLVs are believed to have entered the germ line after the initial radiation of lineages in the cat family but before the radiation of domestic cat lineage species (3,23,25), although subsequent additional integrations into the germ line may also have occurred (50).Endogenous FeLV sequences do not by themselves produce infectious virus but readily recombine with exogenous feline leukemia viruses, notably in the env region that codes for the viral coat, producing recombinant viruses with altered biological activity and pathogenicity (4,17,21,43,44,51,53,54,60). For example, the recombinant subgroup C viruses have been found to induce aplastic anemia (18). Furthermore, portions of the enFeLV env region are transcribed and translated in lymphoma and other cell lines (26), producing a truncated envelope protein that inhibits infection by exogenous subgroup B feline leukemia viruses (26). Transcription and translation of enFeLVs have also been demonstrated in tissues from healthy cats, including lymphoid tissue, suggesting a protective role for enFeLVs in vivo (7, 26). Likewise, inoculation with recombinant subgroup B exogenous FeLV attenuates ...

show abstract

Molecular cloning and characterization of a defective recombinant feline leukaemia virus associated with myeloid leukaemia

Cited by 39 publications

References 32 publications

Identification of Exogenous Forms of Human-Tropic Porcine Endogenous Retrovirus in Miniature Swine

Identification of Exogenous Forms of Human-Tropic Porcine Endogenous Retrovirus in Miniature Swine

Frequency and hematological alterations of different hemoplasma infections with retrovirusis co-infections in domestic cats from Brazil

Insertional Polymorphisms of Endogenous Feline Leukemia Viruses

Contact Info

Product

Resources

About