Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP)

Membrane Topology and Intracellular Processing of Cyclin M2 (CNNM2)

“…7B). This interaction is specific, as evi- denced by the fact that CNNM2a and CNNM2b hardly dimerize with CNNM4, which shares the highest sequence homology with CNNM2 (96.7% similarity and 81.4% identity at the protein level) (5).…”

“…Interestingly, no other electrolyte disturbance was detected (3). CNNM2, formerly known as ancient conserved domain protein 2 (ACDP2), belongs to the CNNM family consisting of four proteins (CNNM1-4) that share homology to cyclins, although no cyclin-related function has been described (5). Two predicted CNNM2 protein isoforms are conserved between humans and mouse.…”

Magnesium in Man: Implications for Health and Disease

“…Members of the Cyclin M (CNNM) family have been proposed to function as Mg 2ϩ transporters (184,545).…”

PRL2 links magnesium flux and sex-dependent circadian metabolic rhythms

“…Thus, correlating with the enhanced BAT thermogenesis observed, the overall increase in energy dissipation can explain the reason PRL2-KO mice are underweight, even though they exhibited increased food intake and O 2 consumption, especially in female mice. Mg 2+ transporter CNNMs contain tandem pairs of cystathionine-β-synthase (CBS) domains that are conserved in all living cells from prokaryotes to eukaryotes (48,49). CBS domains act as energy-sensing modules; for instance, the γ subunit of AMPK possesses 4 CBS domains with allosteric binding sites for AMP as well as ATP, allowing AMPK activity to vary according to the intracellular ATP:AMP ratio (50).…”