Molecular clocks, type 2 diabetes and cardiovascular disease

Prasai, Madhu Janina; George, Jyothis T.; Scott, Eleanor M.

doi:10.3132/dvdr.2008.015

Cited by 68 publications

(44 citation statements)

References 98 publications

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“…There are now many indications that the circadian clock plays a major role in the development of type 2 diabetes (27)(28)(29)(30). To our knowledge it is the first time when diurnal preference was assessed in diabetic patients as a marker of the circadian timing.…”

Section: Discussionmentioning

confidence: 99%

Self-Reported Diurnal Preference and Sleep Disturbance in Type 2 Diabetes Mellitus

Voinescu¹

2011

Acta Endo (Buc)

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Section: Discussionmentioning

confidence: 99%

Self-Reported Diurnal Preference and Sleep Disturbance in Type 2 Diabetes Mellitus

Voinescu¹

2011

Acta Endo (Buc)

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“…The elegant work of Radziuk and Pye (28) provided a deeper and fascinating insight with the hypothesis that the observed diurnal temporal pattern in EGP might result from factors counteracting insulin action and triggered by the brain through central regulatory pathways. Nowadays, the concept of diurnal rhythmicity in insulin sensitivity finds novel relevance in light of the more extensive concept of a "molecular clock," which has been shown to regulate the expression and function of a variety of enzymes, transport systems, and nuclear receptors involved in lipid and carbohydrate metabolism (36)(37)(38).…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics and Pharmacodynamics of Insulin Glargine Given in the Evening as Compared With in the Morning in Type 2 Diabetes

et al. 2014

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OBJECTIVETo compare pharmacokinetics (PK) and pharmacodynamics (PD) of insulin glargine in type 2 diabetes mellitus (T2DM) after evening versus morning administration. RESEARCH DESIGN AND METHODSTen T2DM insulin-treated persons were studied during 24-h euglycemic glucose clamp, after glargine injection (0.4 units/kg s.c.), either in the evening (2200 h) or the morning (1000 h). RESULTSThe 24-h glucose infusion rate area under the curve (AUC 0-24h ) was similar in the evening and morning studies (1,058 6 571 and 995 6 691 mg/kg 3 24 h, P = 0.503), but the first 12 h (AUC 0-12h ) was lower with evening versus morning glargine (357 6 244 vs. 593 6 374 mg/kg 3 12 h, P = 0.004), whereas the opposite occurred for the second 12 h (AUC 12-24h 700 6 396 vs. 403 6 343 mg/kg 3 24 h, P = 0.002). The glucose infusion rate differences were totally accounted for by different rates of endogenous glucose production, not utilization. Plasma insulin and C-peptide levels did not differ in evening versus morning studies. Plasma glucagon levels (AUC 0-24h 1,533 6 656 vs. 1,120 6 344 ng/L/h, P = 0.027) and lipolysis (free fatty acid AUC 0-24h 7.5 6 1.6 vs. 8.9 6 1.9 mmol/L/h, P = 0.005; b-OH-butyrate AUC 0-24h 6.8 6 4.7 vs. 17.0 6 11.9 mmol/L/h, P = 0.005; glycerol, P < 0.020) were overall more suppressed after evening versus morning glargine administration. CONCLUSIONSThe PD of insulin glargine differs depending on time of administration. With morning administration insulin activity is greater in the first 0-12 h, while with evening administration the activity is greater in the 12-24 h period following dosing. However, glargine PK and plasma C-peptide levels were similar, as well as glargine PD when analyzed by 24-h clock time independent of the time of administration. Thus, the results reflect the impact of circadian changes in insulin sensitivity in T2DM (lower in the night-early morning vs. afternoon hours) rather than glargine per se.

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“…Circadian rhythms are maintained by internal clocks and mediate physiology and metabolism in plants and animals (McClung, 2006;Wijnen and Young, 2006;Bass and Takahashi, 2010;Chen, 2010). In humans, energy intake and metabolism have a diurnal rhythm, and disturbance of the circadian rhythms leads to pathogenesis, including obesity, type 2 diabetes, and cardiovascular diseases (Prasai et al, 2008;Bass and Takahashi, 2010). clock2/2 mutant mice lacking a diurnal feeding rhythm are hyperphagic and obese and develop a series of metabolic syndromes (Turek et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

A Role for CHH Methylation in the Parent-of-Origin Effect on Altered Circadian Rhythms and Biomass Heterosis inArabidopsisIntraspecific Hybrids

Miller

et al. 2014

The Plant Cell

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Hybrid plants and animals often show increased levels of growth and fitness, a phenomenon known as hybrid vigor or heterosis. Circadian rhythms optimize physiology and metabolism in plants and animals. In plant hybrids and polyploids, expression changes of the genes within the circadian regulatory network, such as CIRCADIAN CLOCK ASSOCIATED1 (CCA1), lead to heterosis. However, the relationship between allelic CCA1 expression and heterosis has remained elusive. Here, we show a parent-of-origin effect on altered circadian rhythms and heterosis in Arabidopsis thaliana F1 hybrids. This parent-of-origin effect on biomass heterosis correlates with altered CCA1 expression amplitudes, which are associated with methylation levels of CHH (where H = A, T, or C) sites in the promoter region. The direction of rhythmic expression and hybrid vigor is reversed in reciprocal F1 crosses involving mutants that are defective in the RNA-directed DNA methylation pathway (argonaute4 and nuclear RNA polymerase D1a) but not in the maintenance methylation pathway (methyltransferase1 and decrease in DNA methylation1). This parent-of-origin effect on circadian regulation and heterosis is established during early embryogenesis and maintained throughout growth and development.

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Molecular clocks, type 2 diabetes and cardiovascular disease

Cited by 68 publications

References 98 publications

Self-Reported Diurnal Preference and Sleep Disturbance in Type 2 Diabetes Mellitus

Self-Reported Diurnal Preference and Sleep Disturbance in Type 2 Diabetes Mellitus

Pharmacokinetics and Pharmacodynamics of Insulin Glargine Given in the Evening as Compared With in the Morning in Type 2 Diabetes

A Role for CHH Methylation in the Parent-of-Origin Effect on Altered Circadian Rhythms and Biomass Heterosis inArabidopsisIntraspecific Hybrids

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