Molecular characterization of Streptococcus mutans strains isolated from the heart valve of an infective endocarditis patient

Nemoto, Hirotoshi; Nakano, Kazuhiko; Nomura, Ryota; Ooshima, Takashi

doi:10.1099/jmm.0.47836-0

Cited by 18 publications

(12 citation statements)

References 16 publications

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“…al. (2008) found the S. mutans blood isolates were defective in Gtfs, and they had a lower susceptibility to phagocytosis and were different from the typical oral strains [124], [125].…”

Section: Resultsmentioning

confidence: 99%

Sequencing and Comparative Genome Analysis of Two Pathogenic Streptococcus gallolyticus Subspecies: Genome Plasticity, Adaptation and Virulence

Lin¹,

Liu²,

Teng³

et al. 2011

PLoS ONE

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Streptococcus gallolyticus infections in humans are often associated with bacteremia, infective endocarditis and colon cancers. The disease manifestations are different depending on the subspecies of S. gallolyticus causing the infection. Here, we present the complete genomes of S. gallolyticus ATCC 43143 (biotype I) and S. pasteurianus ATCC 43144 (biotype II.2). The genomic differences between the two biotypes were characterized with comparative genomic analyses. The chromosome of ATCC 43143 and ATCC 43144 are 2,36 and 2,10 Mb in length and encode 2246 and 1869 CDS respectively. The organization and genomic contents of both genomes were most similar to the recently published S. gallolyticus UCN34, where 2073 (92%) and 1607 (86%) of the ATCC 43143 and ATCC 43144 CDS were conserved in UCN34 respectively. There are around 600 CDS conserved in all Streptococcus genomes, indicating the Streptococcus genus has a small core-genome (constitute around 30% of total CDS) and substantial evolutionary plasticity. We identified eight and five regions of genome plasticity in ATCC 43143 and ATCC 43144 respectively. Within these regions, several proteins were recognized to contribute to the fitness and virulence of each of the two subspecies. We have also predicted putative cell-surface associated proteins that could play a role in adherence to host tissues, leading to persistent infections causing sub-acute and chronic diseases in humans. This study showed evidence that the S. gallolyticus still possesses genes making it suitable in a rumen environment, whereas the ability for S. pasteurianus to live in rumen is reduced. The genome heterogeneity and genetic diversity among the two biotypes, especially membrane and lipoproteins, most likely contribute to the differences in the pathogenesis of the two S. gallolyticus biotypes and the type of disease an infected patient eventually develops.

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“…al. (2008) found the S. mutans blood isolates were defective in Gtfs, and they had a lower susceptibility to phagocytosis and were different from the typical oral strains [124], [125].…”

Section: Resultsmentioning

confidence: 99%

Sequencing and Comparative Genome Analysis of Two Pathogenic Streptococcus gallolyticus Subspecies: Genome Plasticity, Adaptation and Virulence

Lin¹,

Liu²,

Teng³

et al. 2011

PLoS ONE

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“…is occasionally isolated from the bloodstream of patients with bacteremia and infected heart valve specimens extirpated from patients with infective endocarditis (Nemoto et al 2008). Common feature of these serotype k S.m.…”

Section: Streptococcus Mutans Groupmentioning

confidence: 99%

Point-of-care salivary microbial tests for detection of cariogenic species — Clinical relevance thereof — review

2010

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Dental caries is a highly prevalent multifactorial disease that can result in serious health impairment. It was shown that oral bacteria play a significant role in caries development. Point-of-care (POC) salivary microbial tests for detection of cariogenic species have been investigated as a potential tool for caries risk assessment. This review aims to evaluate clinical relevance of these tests in the light of recent scientific evidence. Methodology involved PubMed search using key words salivary microbial tests, cariogenic bacteria and caries risk prediction. Articles obtained by the search were cross-referenced to obtain further sources. Specificity and negative-predictive value of these tests are higher than their sensitivity and positive value. Predictive power of the POC salivary microbial tests as a single predictor is generally weak, although it increases when included in multifactorial models for caries prediction. Literature findings support the use of these tests for screening of at-risk individuals in a population of young preschool children without visible caries and for motivation of subjects on individual level. POC salivary microbial tests are simple and inexpensive and, therefore, may be advantageous from public health perspective.

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“…Dental focal infections involve oral microorganisms that contribute to disease development at extraoral sites. Dental conditions such as periodontitis, periapical lesions, dental caries, missing teeth, and pericoronitis have been associated with coronary heart disease, including myocardial infarction, coronary atherosclerosis, and ischemia [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

The flavonoids luteolin and quercetagetin inhibit lipoteichoic acid actions on H9c2 cardiomyocytes

Gutiérrez-Venegas

Bando-Campos

2010

International Immunopharmacology

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Molecular characterization of Streptococcus mutans strains isolated from the heart valve of an infective endocarditis patient

Cited by 18 publications

References 16 publications

Sequencing and Comparative Genome Analysis of Two Pathogenic Streptococcus gallolyticus Subspecies: Genome Plasticity, Adaptation and Virulence

Sequencing and Comparative Genome Analysis of Two Pathogenic Streptococcus gallolyticus Subspecies: Genome Plasticity, Adaptation and Virulence

Point-of-care salivary microbial tests for detection of cariogenic species — Clinical relevance thereof — review

The flavonoids luteolin and quercetagetin inhibit lipoteichoic acid actions on H9c2 cardiomyocytes

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