Point-of-care salivary microbial tests for detection of cariogenic species — Clinical relevance thereof — review

Lenčová, E.; Broukal, Z; Spížek, J.

doi:10.1007/s12223-010-0090-x

Cited by 13 publications

(20 citation statements)

References 102 publications

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“…Xerostomia is mentioned in the literature as one of the adverse effects of methylphenidate (23). While some authors have reported that methylphenidate causes dry mouth (24), others have not observed any change in SFR associated with this drug (25).…”

Section: Discussionmentioning

confidence: 99%

Effect of Using Methylphenidate on Salivary Flow Rate and Salivary Buffering Capacity in Children with Attention-Deficit/Hyperactivity Disorder

Kalyoncu¹,

Kurel²,

Tanboğa³

2017

West Indian Med J

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Objective: Most drugs used to treat attention-deficit/hyperactivity disorder treatment can effect saliva secretion. Methylphenidate is the most commonly prescribed drug for the treatment of attention-deficit/hyperactivity disorder and was approved for use in children over the age of 6 years. However, limited information is available on the use and long-term adverse effects of methylphenidate in preschool children (<6 years). We explored the effects of methylphenidate on salivary flow rate and salivary buffering capacity during treatment for attentiondeficit/hyperactivity disorder. Methods: Children who were diagnosed with attention-deficit/hyperactivity disorder by expert psychiatrists, under medical treatment, and those who had no other systemic diseases were included. Stimulated saliva samples were collected before prescription of methylphenidate and after 15 days, 30 days, and 3 months of regular drug intake. The samples were analysed for S.mutans, as well as salivary buffering capacity and salivary flow rate. Twenty children (age range, 6-15 years) with attention-deficit/hyperactivity disorder were included. Results: The mean salivary buffering capacity value at month 3 was significantly lower than that at baseline and at day 15. Regarding the distribution according to salivary flow rate, statistically significant differences were found between baseline and the first month and between baseline and month 3 These results indicate that methylphenidate consumption in children with attentiondeficit/hyperactivity disorder leads to reduced salivary buffering capacity and salivary flow rate after 3 months of follow-up. Conclusions: Parents should be informed about necessary preventive dental treatments to minimise the negative oral and dental effects of long-term drug use in children.

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Section: Discussionmentioning

confidence: 99%

Effect of Using Methylphenidate on Salivary Flow Rate and Salivary Buffering Capacity in Children with Attention-Deficit/Hyperactivity Disorder

Kalyoncu¹,

Kurel²,

Tanboğa³

2017

West Indian Med J

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“…Higher levels of Streptococcus mutans and lactobacilli increase the risk of dental caries . S. mutans have specifically been found to be associated with WSL due to their highly cariogenic properties . Saliva samples from orthodontic patients showed increase in overall oral bacteria counts after the placement of orthodontic appliances .…”

Section: Introductionmentioning

confidence: 99%

“…12 S. mutans have specifically been found to be associated with WSL due to their highly cariogenic properties. 13 Saliva samples from orthodontic patients showed increase in overall oral bacteria counts after the placement of orthodontic appliances. 14,15 Following orthodontic treatment and bracket removal, S. mutans levels return to normal levels.…”

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confidence: 98%

Risk assessments in orthodontic patients developing white spot lesions

Leeper

Noureldin²,

Julien³

et al. 2019

J of Invest & Clin Dent

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Aim To determine whether caries risk factors, including cariogenic bacterial levels and salivary function, can be used to identify orthodontic patients who develop white spot lesions (WSL). Methods This prospective case‐control study comprised 50 patients 11‐17 years of age, including 25 controls and 25 cases who developed new WSL during treatment. WSL, oral hygiene and fluorosis were evaluated from intraoral photographs. The biofilm was assessed with bacterial cultures and adenosine triphosphate (ATP) bioluminescence. Salivary analyses were performed to determine the pH of saliva and flow rates. A survey was used to assess snacking frequency, oral hygiene and fluoride utilization. Results There were no between‐group pretreatment differences in WSL. Cases reported eating sugary foods significantly more often than the controls. There was a significant decline in oral hygiene during treatment, with no significant between‐group difference. There also were no statistically significant between‐group differences in the amount of saliva, buffer, ATP bioluminescence and bacterial levels. Both groups showed lower than normal buffer capacity and high bacterial levels. Conclusion Cases had greater sugar intake between meals than controls. ATP bioluminescence, Streptococcus mutans levels with Saliva Check Mutans, and salivary factors do not identify patients who develop WSL.

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“…Saliva can modulate the process of decay as a rich source of host factors, each of which plays a role in preventing dental caries (7,8). It has been well-documented that saliva secretion and its contents play a significant role in dental health (5,9).…”

Section: Introductionmentioning

confidence: 99%

Salivary Tumor Necrosis Factor-Alpha and Dental Caries in Children and Adolescents

Nazemisalman

Jafari²,

Esmaelzadeh

et al. 2018

Iran J Pediatr

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Background: Dental caries is one of the most common diseases during childhood. Saliva can modulate the process of decay, as a rich source of host factors. It has been shown that tumor necrosis factor-alpha (TNF-α) is secreted more in the saliva of individuals with active caries. No study has addressed the relationship between TNF-α levels and age or compared children's immune response at different age groups and during adolescence. Objectives: The present study aimed at evaluating the pro-inflammatory cytokine level of TNF-α in saliva and its association with caries in different age groups of children and adolescents. Methods: In this case-control study, 128 children and adolescents were divided to four age groups of 32. In each group, half of the individuals had no decay (control group) and the other half had > 4 decayed teeth (case group). Overall, 5 mL of non-stimulated saliva was spitted in sterile tubes for 15 minutes. Furthermore, 1 mL of each sample was centrifuged for five minutes at 12000 rpm. Salivary level of TNF-α was measured using the Enzyme Linked Immunosorbent Assay (ELISA) standard kit. Results: A total of 79 children were studied. The mean TNF-α levels in the case group was 35.20 ± 16.23 Pg/mL and in the control group, this was 26.20 ± 6.25 Pg/mL (P value = 0.001). The mean TNF-α level was significantly higher in the age group of six to 12 years than the age group of 13 to 18 years (P value = 0.01). Conclusions: The results of this study indicated that decay plays an important role in increasing cytokine TNF-α in non-stimulatory saliva, there is no confirming evidence of the direct effect of age on immune function yet.

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Point-of-care salivary microbial tests for detection of cariogenic species — Clinical relevance thereof — review

Cited by 13 publications

References 102 publications

Effect of Using Methylphenidate on Salivary Flow Rate and Salivary Buffering Capacity in Children with Attention-Deficit/Hyperactivity Disorder

Effect of Using Methylphenidate on Salivary Flow Rate and Salivary Buffering Capacity in Children with Attention-Deficit/Hyperactivity Disorder

Risk assessments in orthodontic patients developing white spot lesions

Salivary Tumor Necrosis Factor-Alpha and Dental Caries in Children and Adolescents

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