Molecular characterization of rotavirus diarrhea among children in South Korea: detection of an unusual G11 strain

Abstract

Among 312 rotavirus-positive samples collected from eight hospitals across South Korea during 2008 and 2009, the most prevalent circulating G genotype was G1 (35.9%), followed by G3 (24.7%), G2 (17.0%), G4 (7.7%), and G9 (2.6%). Notably, one unusual G11 lineage III strain-the first hypoendemic infection case in the world-was found. Of the P genotypes, P[8] (43.9%) was the most common, followed by P[6] (29.5%), P[4] (9.3%) and P[9] (0.6%). Determining G- and P-type combinations showed that G1P[8] was the most prevalent (20.5%), followed by G2P[6] (12.8%) and G3P[8] (12.8%). These findings provide new information concerning the current prevalence and spread of the rare G11 rotavirus.

Molecular characterization of group A bovine rotavirus in southeastern and central-western Brazil, 2009-2010

“…Hussein et al's study (1993) conϐirmed the existence of the G11 genotype in samples of bovine rotavirus and other uncommon strains in the United States. The participation of genotype G11, which is typically considered porcine and has also been identiϐied in humans (Bányai et al 2009, Rahman et al 2005, Shim et al 2011, was also observed in the present work. This ϐinding can be considered of major epidemiological signiϐicance in view of the scanty reports of this genotype in Brazilian cattle, and may be a result of sharinf of the same environment by cattle and pigs.…”

Distribution of rotavirus G and P genotypes approximately two years following the introduction of rotavirus vaccines in South Korea

“…Among the rotavirus‐positive samples, the most detected rotavirus genotypes were G1P[8], followed by G3P[8], G4P[6], and G9P[8]. Previous rotavirus surveillance studies in Korea revealed that G1 was the predominant genotype before 1997 [Kim et al, ], and was again predominant from 2004 to 2009 [Lee et al, ; Le et al, ; Shim et al, ]. G2 and G3 were predominant during the seasons of 1999–2002 and 2003–2005, respectively.…”

“…Although G9 was first detected in South Korea in 2002, its prevalence in rural healthcare centers has increased from 7.4% to 39% [Kang et al, , ; Han et al, ] while remaining much lower (from 1% to 3%) in urban hospitals [Lee et al, ; Le et al, ; Kim et al, ; Jeong et al, ; Shim et al, ]. Even though current epidemiological data have been collected from nationwide or individual studies from South Korean provinces, the continuous study in Seoul is significant particularly because this city is the world's second largest metropolitan city.…”

“…Rotavirus G9 strains had not been detected before 2000 [Seo and Sim, ]. Since it was first reported in 2002, the G9 strain has become the fifth most prevalent genotype in South Korea [Kim et al, ] and has been detected in consecutive seasons across the country [Kang et al, ; Le et al, ; Shim et al, ].…”

Genomic characterization of a cell-culture-adapted Korean human G9P[8] rotavirus, CAU05-202

“…In South Korea, G9 rotavirus has emerged as a fifth prevalent genotype since it was first detected in 2002 [14], although its prevalence is much lower than that of the predominant strain G1-G4. Studies have shown that its prevalence at a rural health care center has reached 39% [15] while remaining much lower (0.6-3.9%) in urban hospitals [10,31].…”