1997
DOI: 10.1097/00006123-199710000-00023
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Molecular Characterization of Glioblastoma Cell Differentiation

Abstract: The butyrate-induced responses of the U138B cell line provide a convenient model system for studying the molecular events accompanying the differentiation of glioblastoma cells. Multiparameter flow cytometry is a useful technique for characterizing such differentiation.

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Cited by 28 publications
(24 citation statements)
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“…2,3 Manipulation of GFAP levels in malignant glioma cells suggests an association between GFAP expression and a reduced transformed state. [4][5][6][7][8][9] Brain fatty acid-binding protein (B-FABP; also known as FABP7 or BLBP) is a marker of radial glial cells. 10,11 B-FABP has been implicated in the establishment of the radial glial fiber system required for the migration of neurons to their correct location in the central nervous system and in glial cell differentiation.…”
Section: Introductionmentioning
confidence: 99%
“…2,3 Manipulation of GFAP levels in malignant glioma cells suggests an association between GFAP expression and a reduced transformed state. [4][5][6][7][8][9] Brain fatty acid-binding protein (B-FABP; also known as FABP7 or BLBP) is a marker of radial glial cells. 10,11 B-FABP has been implicated in the establishment of the radial glial fiber system required for the migration of neurons to their correct location in the central nervous system and in glial cell differentiation.…”
Section: Introductionmentioning
confidence: 99%
“…The differentiation effect by 4-PB was previously shown in U138 MG, T98G, U373 MG and A-172 human glioblastoma cell lines (42). They respond quickly (within 72 h) with the retraction of cell borders and extension of long cytoplasmic processes, making the appearance astrocyte-like.…”
Section: Discussionmentioning
confidence: 74%
“…14 Induction of differentiation may allow tumor cells to redifferentiate, suppressing the malignant proliferation of tumors. 2 GFAP is a reliable differentiation marker in normal astrocytes and tumors of the astrocytic lineage. Malignant gliomas have fewer GFAP-positive cells than their benign counterparts and normal brain tissue.…”
Section: Discussionmentioning
confidence: 99%
“…16 GFAP expression and morphological changes in cultured glioma cells should be considered when evaluating cellular differentiation. [1][2][3][4] Rat C6 glioma is a rapidly proliferating cell line with an undifferentiated phenotype and oligodendrocytic, astrocytic and neuronal properties. It has been used as a model to study glial differentiation.…”
Section: Discussionmentioning
confidence: 99%
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