Molecular characterization of chikungunya virus from the first cluster of patients during the 2020 outbreak in Chad

Yonga, Martial; Yandai, Fissou Henry; Sadeuh-Mba, Serge Alain; Abdallah, Alsadick Haroun; Ouapi, Diane; Gamougam, Kadidja; Abanda, Ngu Njei; Endengue-Zanga, Marie Claire; Demanou, Maurice; Njouom, Richard

doi:10.1007/s00705-022-05427-5

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…The spread of the ECSA genotype highlights the impact of travel, trade, and human migration on the CHIKV viral movement [94]. The first importation of the ECSA genotype into Brazil in September 2014 was closely related to the Angolan isolate from 1962 [95].…”

Section: Genetic Diversity and Transmission Dynamics In Africamentioning

confidence: 99%

Understanding the Transmission Dynamics of the Chikungunya Virus in Africa

Ramphal,

Tegally,

San

et al. 2024

Preprint

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The Chikungunya virus (CHIKV) poses a significant global public health concern, especially in Africa. Since its first isolation in Tanzania in 1953, CHIKV has caused recurrent outbreaks, challenging healthcare systems in low-resource settings. Recent outbreaks in Africa highlight the dynamic nature of CHIKV transmission and the challenges of underreporting and underdiagnosis. Here, we review literature and analyze publicly available cases, outbreaks, and genomic data providing insights into the epidemiology, genetic diversity, and transmission dynamics of CHIKV in Africa. Our analyses reveal the circulation of geographically distinct CHIKV genotypes, with certain regions experiencing a disproportionate burden of disease. Phylogenetic analysis of sporadic outbreaks in West Africa suggests repeated emergence of the virus through enzootic spillover, which is markedly different from inferred transmission dynamics in East Africa, where the virus is often introduced from Asian outbreaks, including the recent reintroduction of the Indian Ocean lineage from the Indian subcontinent to east Africa. Furthermore, there is limited evidence of viral movement between these two regions. Understanding the history and transmission dynamics of outbreaks is crucial for public health planning. Despite advances in surveillance and research, diagnostic and surveillance challenges persist. This review and secondary analysis highlight the importance of ongoing surveillance, research, and collaboration to mitigate the burden of CHIKV in Africa and improve public health outcomes.

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Section: Genetic Diversity and Transmission Dynamics In Africamentioning

confidence: 99%

Understanding the Transmission Dynamics of the Chikungunya Virus in Africa

Ramphal,

Tegally,

San

et al. 2024

Preprint

View full text Add to dashboard Cite

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“…CHIKV is identified in an increasing number of African countries (2). Given that most reported outbreaks in the continent are due to the ECSA group (3,4,5,6), existing molecular characterization tools are mainly based on this genotype (7). However, most of the outbreaks in West Africa were due to the WA genotype (8).…”

Section: Introductionmentioning

confidence: 99%

An amplicon-based Illumina and nanopore sequencing workflow for Chikungunya virus West Africa genotype

Dieng,

Ndiaye,

Kane

et al. 2023

Preprint

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The Chikungunya virus, a global arbovirus, is currently causing a major outbreak in the Western African region, with the highest cases reported in Senegal and Burkina Faso. Recent molecular evolution analyses reveal that the strain responsible for the epidemic belongs to the West African genotype, with new mutations potentially impacting viral replication, antigenicity, and host adaptation. Real-time genomic monitoring is needed to track the virus’s spread in new regions. A scalable West African genotype amplicon-based Whole Genome Sequencing for multiple Next Generation Sequencing platforms has been developed to support genomic investigations and identify epidemiological links during the virus’s ongoing spread. This technology will help identify potential threats and support real-time genomic investigations in the ongoing spread of the virus.

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Understanding the Transmission Dynamics of the Chikungunya Virus in Africa

Ramphal,

Tegally,

San

et al. 2024

Pathogens

View full text Add to dashboard Cite

The Chikungunya virus (CHIKV) poses a significant global public health concern, especially in Africa. Since its first isolation in Tanzania in 1953, CHIKV has caused recurrent outbreaks, challenging healthcare systems in low-resource settings. Recent outbreaks in Africa highlight the dynamic nature of CHIKV transmission and the challenges of underreporting and underdiagnosis. Here, we review the literature and analyse publicly available cases, outbreaks, and genomic data, providing insights into the epidemiology, genetic diversity, and transmission dynamics of CHIKV in Africa. Our analyses reveal the circulation of geographically distinct CHIKV genotypes, with certain regions experiencing a disproportionate burden of disease. Phylogenetic analysis of sporadic outbreaks in West Africa suggests repeated emergence of the virus through enzootic spillover, which is markedly different from inferred transmission dynamics in East Africa, where the virus is often introduced from Asian outbreaks, including the recent reintroduction of the Indian Ocean lineage from the Indian subcontinent to East Africa. Furthermore, there is limited evidence of viral movement between these two regions. Understanding the history and transmission dynamics of outbreaks is crucial for effective public health planning. Despite advances in surveillance and research, diagnostic and surveillance challenges persist. This review and secondary analysis highlight the importance of ongoing surveillance, research, and collaboration to mitigate the burden of CHIKV in Africa and improve public health outcomes.

show abstract

Molecular characterization of chikungunya virus from the first cluster of patients during the 2020 outbreak in Chad

Cited by 3 publications

References 15 publications

Understanding the Transmission Dynamics of the Chikungunya Virus in Africa

Understanding the Transmission Dynamics of the Chikungunya Virus in Africa

An amplicon-based Illumina and nanopore sequencing workflow for Chikungunya virus West Africa genotype

Understanding the Transmission Dynamics of the Chikungunya Virus in Africa

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