Molecular characterization of canine parvovirus variants (CPV-2a, CPV-2b, and CPV-2c) based on the VP2 gene in affected domestic dogs in Ecuador

Torre, David De la; Mafla, Eulalia; Puga, Byron; Erazo, Linda; Astolfi-Ferreira, Claudete S.; Ferreira, A. A.

doi:10.14202/vetworld.2018.480-487

Cited by 28 publications

(17 citation statements)

References 44 publications

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“…FJ222824) (45) was found to be identical to the sequence of H503/H506 and to the Nobivac Puppy DP vaccine strain described in Ecuador (GenBank accession no. MG264079) (46). This is the same vaccine that has been used in mass dog vaccination programs in the Serengeti ecosystem.…”

Section: Results In Wildlife (I) Presence Of Infection In Wildlifementioning

confidence: 99%

Carnivore Parvovirus Ecology in the Serengeti Ecosystem: Vaccine Strains Circulating and New Host Species Identified

Calatayud¹,

Esperón

Cleaveland

et al. 2019

J Virol

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Carnivore parvoviruses infect wild and domestic carnivores, and crossspecies transmission is believed to occur. However, viral dynamics are not well understood, nor are the consequences for wild carnivore populations of the introduction of new strains into wild ecosystems. To clarify the ecology of these viruses in a multihost system such as the Serengeti ecosystem and identify potential threats for wildlife conservation, we analyzed, through real-time PCR, 152 samples belonging to 14 wild carnivore species and 62 samples from healthy domestic dogs. We detected parvovirus DNA in several wildlife tissues. Of the wild carnivore and domestic dog samples tested, 13% and 43%, respectively, were positive for carnivore parvovirus infection, but little evidence of transmission between the wild and domestic carnivores was detected. Instead, we describe two different epidemiological scenarios with separate routes of transmission: first, an endemic feline parvovirus (FPV) route of transmission maintained by wild carnivores inside the Serengeti National Park (SNP) and, second, a canine parvovirus (CPV) route of transmission among domestic dogs living around the periphery of the SNP. Twelve FPV sequences were characterized; new host-virus associations involving wild dogs, jackals, and hyenas were discovered; and our results suggest that mutations in the fragment of the vp2 gene were not required for infection of different carnivore species. In domestic dogs, 6 sequences belonged to the CPV-2a strain, while 11 belonged to the CPV-2 vaccinederived strain. This is the first description of a vaccine-derived parvovirus strain being transmitted naturally. IMPORTANCE Carnivore parvoviruses are widespread among wild and domestic carnivores, which are vulnerable to severe disease under certain circumstances. This study furthers the understanding of carnivore parvovirus epidemiology, suggesting that feline parvoviruses are endemic in wild carnivores in the Serengeti National Park (SNP), with new host species identified, and that canine parvoviruses are present in the dog population living around the SNP. Little evidence of transmission of canine parvoviruses into wild carnivore species was found; however, the detection of vaccine-derived virus (described here for the first time to be circulating naturally in domestic dogs) highlights the importance of performing epidemiological research in the region.

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Section: Results In Wildlife (I) Presence Of Infection In Wildlifementioning

confidence: 99%

Carnivore Parvovirus Ecology in the Serengeti Ecosystem: Vaccine Strains Circulating and New Host Species Identified

Calatayud¹,

Esperón

Cleaveland

et al. 2019

J Virol

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“…Other studies confirm that CDV is present in Brazil (Budaszewski et al 2014, Monteiro et al 2016, Alves et al 2018), Chile (Acosta-Jamett et al 2011, Colombia (Espinal et al 2014), Cuba (González-Chávez et al 2017), Ecuador (DiGangi et al 2019 including the Galápagos Islands (Levy et al 2008 (Gizzi et al 2014) [EB1]. Other studies show that CPV2 is present in Argentina (Calderón et al 2011(Calderón et al , 2015, Brazil (Alves et al 2018, Headley et al 2018, Chile (Acosta-Jamett et al 2015), Colombia (Duque-García et al 2017), Cuba (Pino-Rodríguez et al 2018), Ecuador (Levy et al 2008, Aldaz et al 2013, De la Torre et al 2018, DiGangi et al 2019, Mexico (Ortega et al 2017) and Uruguay (Pérez et al 2007, Puentes et al 2012, Maya et al 2013 [EB1].…”

Section: Canine Distemper Virusmentioning

confidence: 99%

Recommendations on vaccination for Latin American small animal practitioners: a report of the WSAVA Vaccination Guidelines Group

Day

Crawford

Marcondes

et al. 2020

J of Small Animal Practice

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Executive Summary The World Small Animal Veterinary Association Vaccination Guidelines Group has produced global guidelines for small companion animal practitioners on best practice in canine and feline vaccination. Recognising that there are unique aspects of veterinary practice in certain geographical regions of the world, the Vaccination Guidelines Group undertook a regional project in Latin America between 2016 and 2019, culminating in the present document. The Vaccination Guidelines Group gathered scientific and demographic data during visits to Argentina, Brazil and Mexico, by discussion with national key opinion leaders, visiting veterinary practices and review of the scientific literature. A questionnaire survey was completed by 1390 veterinarians in five Latin American countries and the Vaccination Guidelines Group delivered continuing education at seven events attended by over 3500 veterinarians. The Vaccination Guidelines Group recognised numerous challenges in Latin America, for example: (1) lack of national oversight of the veterinary profession, (2) extraordinary growth in private veterinary schools of undetermined quality, (3) socioeconomic constraints on client engagement with preventive health care, (4) high regional prevalence of some key infectious diseases (e.g. feline leukaemia virus infection, canine visceral leishmaniosis), (5) almost complete lack of minimal antigen vaccine products as available in other markets, (6) relative lack of vaccine products with extended duration of immunity as available in other markets, (7) availability of vaccine products withdrawn from other markets (e.g. Giardia vaccine) or unique to Latin America (e.g. some Leishmania vaccines), (8) accessibility of vaccines directly by pet owners or breeders such that vaccination is not delivered under veterinary supervision, (9) limited availability of continuing education in veterinary vaccinology and lack of compulsion for continuing professional development and (10) limited peer‐reviewed published scientific data on small companion animal infectious diseases (with the exception of leishmaniosis) and lack of support for such academic research. In this document, the Vaccination Guidelines Group summarises the findings of this project and assesses in evidence‐based fashion the scientific literature pertaining to companion animal vaccine‐preventable diseases in Latin America. The Vaccination Guidelines Group makes some recommendations on undergraduate and postgraduate education and academic research. Recognising that current product availability in Latin America does not permit veterinarians in these countries to vaccinate according to the global World Small Animal Veterinary Association guidelines, the Vaccination Guidelines Group makes a series of “pragmatic” recommendations as to what might be currently achievable, and a series of “aspirational” recommendations as to what might be desirable for the future. The concept of “vaccine husbandry” is addressed via some simple guidelines for the management of vaccine products i...

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“…На відмінності у структурі вакцинних та патогенних штамів вказують також дослідження вчених Еквадору та Угорщини. У цих країнах спостерігається захворювання цуценят парвовірусним ентеритом на фоні щеплення проти даної хвороби (Csagola, Varga, Lorincz, & Tuboly, 2014;De la Torre et al, 2018).…”

Section: матеріал і методи дослідженьunclassified

The analysis of canine parvovirus strains based on the sequence VP-2 GENE

Yurko¹,

Щербак²,

Borovkova³

et al. 2019

VTTP

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Molecular characterization of canine parvovirus variants (CPV-2a, CPV-2b, and CPV-2c) based on the VP2 gene in affected domestic dogs in Ecuador

Cited by 28 publications

References 44 publications

Carnivore Parvovirus Ecology in the Serengeti Ecosystem: Vaccine Strains Circulating and New Host Species Identified

Carnivore Parvovirus Ecology in the Serengeti Ecosystem: Vaccine Strains Circulating and New Host Species Identified

Recommendations on vaccination for Latin American small animal practitioners: a report of the WSAVA Vaccination Guidelines Group

The analysis of canine parvovirus strains based on the sequence VP-2 GENE

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