Molecular characterization of a series of solitary fibrous tumors, including immunohistochemical expression of STAT6 and NATB2-STAT6 fusion transcripts, using Reverse Transcriptase(RT) – Polymerase chain reaction(PCR) technique: An Indian experience

Rekhi, Bharat; Shetty, Omshree; Tripathi, Parul; Bapat, Prachi; Ramadwar, Mukta; Bajpai, Jyoti; Puri, Ajay

doi:10.1016/j.prp.2017.08.011

Cited by 29 publications

(20 citation statements)

References 21 publications

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“…The STAT6-NAB2 fusion product results from an inversion at the 12q13 locus inducing expression of early growth response (EGR) mediated pathways (15). These fusions have been demonstrated by polymerase chain reaction to be present in 91% of SFT, with absence of this function in potentially histologically similar appearing tumors (44). This fusion may also be detected by a break-apart fluorescent in situ hybridization probe, seen in 58% of cases in one study (45).…”

Section: Histopathologymentioning

confidence: 93%

Solitary fibrous tumor

Davanzo¹,

Emerson²,

Lisy³

et al. 2018

Transl. Gastroenterol. Hepatol

126

157

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Solitary fibrous tumor (SFT) is a rare tumor of mesenchymal origin that account for less than 2% of all soft tissue masses. Initially identified in the pleura, SFT has been identified in multiple anatomic locations and can arise anywhere in the body. The varying histologic features along with non-specific means of identification have led SFT to be associated with several different names. Over the last several decades, sustained advances through research and technology have led to more reliable methods for differentiating this distinct soft tissue tumor. Advances specifically in immunohistochemistry and molecular diagnostics have identified CD34 as the most consistent marker in SFT, however even this lacks specificity to conclusively narrow down the broad differential for exact identification. More recently the discovery of the NAB2-STAT6 fusion gene has led to more precise diagnosis of SFT. Like many other soft tissue tumors, surgical management is the mainstay of treatment for SFT with emphasis on obtaining tumor-negative margins. Radiation therapy and chemotherapy regimens have not demonstrated global effectiveness, and thus no standardized treatments have been identified. Given the rarity of SFT and current supportive evidence for therapies, management should be focused on tumor extirpation. Nonetheless, individualized therapy, determined within a multidisciplinary setting should be considered.

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Section: Histopathologymentioning

confidence: 93%

Solitary fibrous tumor

Davanzo¹,

Emerson²,

Lisy³

et al. 2018

Transl. Gastroenterol. Hepatol

126

157

View full text Add to dashboard Cite

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“…However, we considered the possibility of SFT being diagnosed simply through STAT6. Literature from the past 5 years was searched, and we found that STAT6 immunohistochemistry has high specificity for SFT and that the diagnostic value of strong and diffuse nuclear expression of STAT6 in SFT has been proven . It was also found that STAT6 is a dependable marker to differentiate SFT from myofibromas .…”

Section: Discussionmentioning

confidence: 94%

“…Literature from the past 5 years was searched, and we found that STAT6 immunohistochemistry has high specificity for SFT and that the diagnostic value of strong and diffuse nuclear expression of STAT6 in SFT has been proven. [18][19][20] It was also found that STAT6 is a dependable marker to differentiate SFT from myofibromas. 21 At the same time, follicular lymphomaassociated STAT6 mutations facilitate nuclear residency of STAT6, 22 while nuclear localization of STAT6 is also dramatically increased in Kaposi's sarcoma tissue.…”

Section: Discussionmentioning

confidence: 97%

A case of solitary fibrous tumor/hemangiopericytoma in the central nervous system with papillary morphology

et al. 2019

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This report describes the clinicopathological findings of a solitary fibrous tumor (SFT)/hemangiopericytoma (HPC) of the central nervous system in a 59‐year‐old man with space‐occupying lesions on both the left anterior basicranial and on the top tail of falx cerebri. The tumor showed small quantities of solid papillary areas and a prominent papillary structure, where atypical cells were compactly arranged along the fibrovascular core. The tumor cells of both components showed nuclear relocalization of the signal transducer and activator of transcription 6 protein, with very high specificity and sensitivity for the diagnosis of SFT/HPC. In the literature, only three cases of SFTs with a papillary pattern have been reported, but this case showed a complete papillary pattern. “Papillary” SFT/HPC is a rare morphological variant of SFTs/HPCs, and its differential diagnosis among intracranial tumors is an important factor which clinicians should bear in mind during diagnosis.

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“…The positive rates were 96.8% (60/62) and 100% (49/49), indicating that STAT6 has a higher sensitivity for SFT detection. STAT6 test results are of great value for diagnosis, especially for CD34‐negative SFT cases . However, we should know that STAT6 immunohistochemistry staining could not replace the detection of the NAB2‐STAT6 fusion gene completely.…”

Section: Discussionmentioning

confidence: 99%

Malignant solitary fibrous tumor occurring in the mediastinal pleura showing NAB2ex4‐STAT6ex2 fusion and negative STAT6 immunohistochemistry: A case report

Zhang

Xiong

et al. 2020

Thoracic Cancer

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Solitary fibrous tumor (SFT) is a rare clinical tumor, defined as a mesenchymal tumor of fibroblastic origin. A classic SFT is benign in most cases, but its clinical behavior is unpredictable. Lately, molecular analyses has discovered that almost all SFTs harbor an NAB2-STAT6 fusion gene, which is considered specific to this tumor type. Recent studies have suggested that nuclear STAT6 immunoreactivity is a highly sensitive and specific marker of SFTs and can be helpful when diagnosis is inconclusive by conventional methods. We herein report the case of a rare malignant solitary fibrous tumor occurring in the mediastinal pleura. An 82-year-old Chinese man with intermittent breathlessness was referred to our hospital. Chest CT showed a significantly enhanced irregular huge soft tissue mass in the anterior mediastinal area. After radical resection, the immunohistochemistry staining results of the sample showed that STAT6 was negative. The final diagnosis was confirmed by qualitative endpoint reverse transcriptasepolymerase chain reaction technique, showing positive NAB2ex4-STAT6ex2 fusion.

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Molecular characterization of a series of solitary fibrous tumors, including immunohistochemical expression of STAT6 and NATB2-STAT6 fusion transcripts, using Reverse Transcriptase(RT) – Polymerase chain reaction(PCR) technique: An Indian experience

Cited by 29 publications

References 21 publications

Solitary fibrous tumor

Solitary fibrous tumor

A case of solitary fibrous tumor/hemangiopericytoma in the central nervous system with papillary morphology

Malignant solitary fibrous tumor occurring in the mediastinal pleura showing NAB2ex4‐STAT6ex2 fusion and negative STAT6 immunohistochemistry: A case report

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