Molecular characterization, expression and enzyme activity of three glutathione S-transferase genes from Eriocheir sinensis under pesticide stresses

Zhang, Xiao; Shen, Guoqing; Wang, Yan; Huang, Pengdan; Hashim, Kassimu; Zang, Yanan; Shen, Huangxuan

doi:10.1016/j.cbpc.2019.108700

Cited by 3 publications

(1 citation statement)

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“…The increased GR activity in Dourado River basin can represents a response of the Aegla to cope with stress using defenses linked to the glutathione antioxidant system, as well for xenobiotics detoxification by Gluthatione-S-Transferase. This behavior has already been observed in crabs exposed to pesticides avermectin, trichlorphon and β-cypermethrin (Zhang et al, 2020).…”

Section: Discussionsupporting

confidence: 64%

Multiple metals and agricultural use affects oxidative stress biomarkers in freshwater Aegla crabs

et al. 2022

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Metals and agrochemicals are among the main aquatic contaminants, being able to trigger oxidative stress in exposed organisms. The objective of this work was to evaluate the correlation between the level of oxidative stress biomarkers in Aegla crabs (Crustacea, Anomura) with (i) the set of metals present in the streams sediment and (ii) with land uses of three hydrographic basins. The study was carried out in streams (≤ 2nd order) of hydrographic basins in southern Brazil (Basins of Rio Suzana, Rio Ligeirinho-Leãozinho and Rio Dourado). In these streams were quantified the land uses and Cu, Cr, Cd, Fe, Mn and Zn concentrations in the sediment. The enzymes Catalase (CAT) and Glutathione Reductase (GR), as well as the level of membrane lipid peroxidation (TBARS), were analyzed in adult females. The PCA analysis showed that the distribution of metals was different between the basins. Cd, Cr and Fe were correlated positively with CAT and negatively with TBARS and GR. The Dourado basin had the lowest concentrations of these three metals and the highest levels of TBARS. However, in Dourado basin there is predominance of agriculture land use, and TBARS was positively correlated with agricultural land use. Besides in Dourado basin, GR activity was higher than in the others basins, indicating a compensatory response in relation to CAT inhibition. The basins of Suzana and Ligeirinho-Leãozinho rivers had lower TBARS values, which may be due to the induction of CAT in response to metals accumulated in sediment. In summary, this work indicates that in the basins with a higher concentration of toxic metals there is an adaptive response of CAT induction, which reduces TBARS in Aegla. On the other hand, in the basin with lower metallic contamination, TBARS occurrence was primarily influenced by agricultural land use.

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Section: Discussionsupporting

confidence: 64%