Molecular characterization and transcriptional regulation of the sodium-dependent vitamin C transporter genes (slc23a1 and slc23a2) in a teleost fish, the Senegalese sole (Solea senegalensis)

Jiménez-Fernández, Eduardo; Ponce, Marian; Zuasti, Eugenia; Fernández‐Díaz, Catalina; Manchado, Manuel; Infante, Carlos

doi:10.1016/j.cbpb.2011.11.010

Cited by 10 publications

(6 citation statements)

References 64 publications

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“…Means are followed by different letter within the column are significantly different (P < 0.05). (ANOVA followed by LSD test) (Aysun, 2009), amidation of peptide hormones (Jimenez-Fernandez et al, 2012), metabolism of iron (James, 2001) and immunity (Anbarasu and Chandran, 2001;Ai et al, 2006) or by acting as a resistant modulator (Tewary and Patra, 2008;Eo and Lee, 2008).…”

Section: Discussionmentioning

confidence: 99%

Effects of Graded Level of Dietary L-Ascorbyl-2-Polyphosphate on Growth Performance and Some Hematological Indices of Juvenile Mahseer (Tor putitora)

Khan¹,

Zuberi²,

Ullah³

et al. 2015

IJAB

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A 70 days feeding trial was conducted to evaluate the effects of graded level of L-ascorby-2-polyphosphate (APP) on growth performance and hematological indices of juvenile mahseer Tor putitora. Four different 40% protein experimental diets supplemented with APP at the rate of 0, 100, 200 and 300 mg APP kg-1 diet were fed to triplicate group of fish. The APP supplementation showed their effect in a dose dependent manner. Significantly (P < 0.05) improved growth performance i.e. weight gain (WG%), feed conversion efficiency (FCE%), specific growth rate (SGR%) and hepatosomatic index (HSI%) was observed with APP 300 , followed by APP 200 and then APP 100 enriched diet. The growth hormone (GH) level of fish also increased with increase in concentration of APP in the diet and showed a positive relationship with WG%. Moreover, the hematological parameters like red blood cell count, hemoglobin and hematocrit values also followed the same trend in response to graded levels of dietary APP supplementation, significantly (P < 0.05) higher values with APP 300 enriched diet followed by APP 200 diet while comparatively low, but significantly higher (P < 0.05) values as compared to control group of fish were obtained in response to APP 100 supplemented diets. The results of this study indicate the dose dependent beneficial effects of APP on growth performance and hematological indices of T. putitora.

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Section: Discussionmentioning

confidence: 99%

Effects of Graded Level of Dietary L-Ascorbyl-2-Polyphosphate on Growth Performance and Some Hematological Indices of Juvenile Mahseer (Tor putitora)

Khan¹,

Zuberi²,

Ullah³

et al. 2015

IJAB

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“…An increase in SVCT-expression as a response to a reduction in ASC, followed by a decrease in SVCT mRNA when ASC levels increased, has been reported in developing teleost fish, which naturally are unable to synthesize vitC [136]. Although this could be part of a normal developmental sequence of events, it may also be a substrate-dependent response on SVCT-expression by which ASC uptake is regulated [136].…”

Section: Regulation Of Vitc Transport By Substrate Concentrationsmentioning

confidence: 99%

“…Although this could be part of a normal developmental sequence of events, it may also be a substrate-dependent response on SVCT-expression by which ASC uptake is regulated [136]. Studies of senescence marker protein-30 (SMP30)/gluconolactonase (GNL) knockout mice has revealed that vitC depletion increases SVCT1 mRNA levels in liver and small intestine and SVCT2 mRNA in liver [30].…”

Section: Regulation Of Vitc Transport By Substrate Concentrationsmentioning

confidence: 99%

Regulation of Vitamin C Homeostasis during Deficiency

2013

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Large cross-sectional population studies confirm that vitamin C deficiency is common in humans, affecting 5%–10% of adults in the industrialized world. Moreover, significant associations between poor vitamin C status and increased morbidity and mortality have consistently been observed. However, the absorption, distribution and elimination kinetics of vitamin C in vivo are highly complex, due to dose-dependent non-linearity, and the specific regulatory mechanisms are not fully understood. Particularly, little is known about how adaptive mechanisms during states of deficiency affect the overall regulation of vitamin C transport in the body. This review discusses mechanisms of vitamin C transport and potential means of regulation with special emphasis on capacity and functional properties, such as differences in the Km of vitamin C transporters in different target tissues, in some instances demonstrating a tissue-specific distribution.

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“…There are several animals that, like humans, do not synthesize their own AA including guinea pigs, primates and some fish [ 57 ]. Nevertheless, transport is conserved across species and study of AA transporters in situ can be conducted in most animal models.…”

Section: Ascorbic Acid Biochemistry and Transportmentioning

confidence: 99%

Ascorbic Acid and the Brain: Rationale for the Use against Cognitive Decline

2014

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This review is focused upon the role of ascorbic acid (AA, vitamin C) in the promotion of healthy brain aging. Particular attention is attributed to the biochemistry and neuronal metabolism interface, transport across tissues, animal models that are useful for this area of research, and the human studies that implicate AA in the continuum between normal cognitive aging and age-related cognitive decline up to Alzheimer’s disease. Vascular risk factors and comorbidity relationships with cognitive decline and AA are discussed to facilitate strategies for advancing AA research in the area of brain health and neurodegeneration.

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Molecular characterization and transcriptional regulation of the sodium-dependent vitamin C transporter genes (slc23a1 and slc23a2) in a teleost fish, the Senegalese sole (Solea senegalensis)

Cited by 10 publications

References 64 publications

Effects of Graded Level of Dietary L-Ascorbyl-2-Polyphosphate on Growth Performance and Some Hematological Indices of Juvenile Mahseer (Tor putitora)

Effects of Graded Level of Dietary L-Ascorbyl-2-Polyphosphate on Growth Performance and Some Hematological Indices of Juvenile Mahseer (Tor putitora)

Regulation of Vitamin C Homeostasis during Deficiency

Ascorbic Acid and the Brain: Rationale for the Use against Cognitive Decline

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