Molecular characterization and genetic susceptibility of sapovirus in children with diarrhea in Burkina Faso

Diverse sapovirus genotypes identified in children hospitalised with gastroenteritis in selected regions of South Africa

“…The GIV strains from SA shared high nucleotide identity (96-99%) with SaVs identified in patients with gastroenteritis in several countries over the past ten years, including Burkina Faso [14], China [10], the United Kingdom (UK), the United States (US) [9] and Venezuela [33]. This confirms a worldwide distribution of the genotype as well as indicating its presence in southern Africa.…”

“…It is also possible that a higher genetic diversity of SaVs is circulating in children with gastroenteritis on the African continent. A recent study from Burkina Faso reported nine different genotypes characterised over an 11-month period [14] and a previous study from Kenya reported five genotypes from six specimens [18].…”

“…These studies did not focus primarily on hospitalised children with severe gastroenteritis and even fewer studies on SaVs have been conducted in Africa. A recent study (2009)(2010) from Burkina Faso reported nine SaV genotypes in children with gastroenteritis, with infections generally associated with milder symptoms [14]. In Tunisia, SaVs were reported in paediatric outpatients with gastroenteritis and only GI.1 was identified [15].…”

Epidemiological profile and genetic diversity of sapoviruses (SaVs) identified in children suffering from acute gastroenteritis in Pune, Maharashtra, Western India, 2007–2011

“…Higher prevalence (17-18%) has been observed in recent studies using the real-time PCR approach [16,17]. Previous reports available from southern (Vellore) and northern (New Delhi) regions of India, along with Japan, have reported SaV infections in n.s., Non-significant; S, significant.…”

Sapovirus prevalence in children less than five years of age hospitalised for diarrhoeal disease in South Africa, 2009–2013

“…In these studies, SaVs were common during the winter months and in younger children [1]. Sapovirus prevalence has only been described in a few sub-Saharan African countries, including Kenya (5.7% in <14 years) [6], Tanzania (5.7-6.4% in <5 years) [7,8], Malawi (8% in <5 years) [9], South Africa (SA; 4.1-8.4% in all ages) [10,11], Gabon (9.5% in <5 years) [12] and Burkina Faso (18% in <5 years) [13]. These studies utilized molecular methods for SaV detection with an average prevalence of 7.5% (95% CI 3.4%-11.5%) among diarrhoeal cases.…”