Molecular biology of wound healing

Ganapathy, N.; Venkataraman, Siva Subramaniyan; Daniel, Rajkumar; Aravind, Ramraj Jayabalan; Kumarakrishnan, Vilapakkam Bhikshewaran

doi:10.4103/0975-7406.100294

Cited by 33 publications

(22 citation statements)

References 11 publications

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“…Nonetheless, if the above-said scheduled events are disrupted for any reason, the healing trend of skin wound encounters problem, and wound healing speed is affected by them. A lot of factors affect speed and quality of wound healing trend out of which one can refer to size of wound, blood storage on place, the existing external objects and microorganisms, age, health status, and nutrition state of patient [ 7 , 18 – 20 ] ( Table 1 ).…”

Section: Wound Healing Classification and Cell Signalingmentioning

confidence: 99%

The Review on Properties of Aloe Vera in Healing of Cutaneous Wounds

Hashemi

Madani

Abediankenari

2015

BioMed Research International

165

117

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Treatment of wounds is very important and was subject of different investigations. In this regard, natural substance plays crucial role as complementary medicine. Various studies reported that aloe vera has useful effects on wounds especially cutaneous wounds healing. Therefore in the current review, we examined the effect of aloe vera on cutaneous wound healing and concluded that although aloe vera improves the wound healing as well as other procedures both clinically and experimentally, more studies are still needed to approve the outcomes.

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Section: Wound Healing Classification and Cell Signalingmentioning

confidence: 99%

The Review on Properties of Aloe Vera in Healing of Cutaneous Wounds

Hashemi

Madani

Abediankenari

2015

BioMed Research International

165

117

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“…Important cytokines that produce by fibroblast are TGFβ1 and bFGF. TGFβ1 and bFGF impacts on cell division, cell migration, cell differentiation, protein expression, and enzyme production and have the potential ability to heal wounds through stimulation of angiogenesis factors and cellular proliferation which affects the ECM production and degradation through their chemotactic role on inflammatory cells and fibroblasts [20].…”

Section: Discussionmentioning

confidence: 99%

Calendula officinalis stimulate proliferation of mouse embryonic fibroblasts via expression of growth factors TGFβ1 and bFGF

et al. 2019

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Background TGF-β has an important role in the process of wound healing and scar formation. The aim of this study is to determine the effects of ethanolic and methanolic extracts of Calendula officinalis on the expression of TGFβ1 and bFGF in the mouse embryonic fibroblast cells (MEFs). Methods Calendula officinalis extract was purchased and different substances defined with gas chromatography and mass spectrometry. MEFs were prepared and after incubating for 15 min, cell viability analyzed. TGF β 1 and bFGF gene expression was evaluated by real-time PCR. TGFβ1 and bFGF protein expression analyzed by ELISA. The statistical analysis of data was done by using SPSS software. Differences were considered significant at ( P < 0.05). Results The results of the MTT test showed that the concentrations of 5 μg/ml and10 μg/ml were more suitable for cell proliferation. There was an increase in TGF β 1 gene expression in the MEFs. Expression of TGF β 1 gene remains the same after 24 h. Gene expression of bFGF showed a similar pattern with TGF β 1 expression for both solvents. Analysis of TGFβ1 protein expression showed an increase in TGFβ1 gene expression in the MEFs. Protein expression of bFGF in the MEFs increased at different concentrations at 12 and 24 h after treatment ( P < 0.05 and P < 0.01 respectively). Conclusion Calendula officinalis stimulates proliferation of MEFs. Calendula via increased expression of growth factors (TGFβ1 and bFGF) at the first 12 h and a decrease of these factors at 24 h after treatment may ameliorate function of the MEFs in the during wound healing.

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“…It is known that these disaccharides promote CS/DS binding to FGF-2, FGF-7, and/or PDGF [36, 38]. All these molecules play a crucial role in the healing process as regulators of proliferation, migration, survival, and/or secretory activity of such cells as fibroblasts, endothelial cells, and keratinocytes [38, 39]. Growth factor binding to CS/DS protects the regulators from proteolysis and/or concentrates them near their cell receptors [36, 37].…”

Section: Discussionmentioning

confidence: 99%

Propolis Induces Chondroitin/Dermatan Sulphate and Hyaluronic Acid Accumulation in the Skin of Burned Wound

Olczyk

Komosińska-Vassev

Winsz-Szczotka

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Changes in extracellular matrix glycosaminoglycans during the wound repair allowed us to apply the burn model in which therapeutic efficacy of propolis and silver sulfadiazine was compared. Burns were inflicted on four pigs. Glycosaminoglycans isolated from healthy and burned skin were quantified using a hexuronic acid assay, electrophoretic fractionation, and densitometric analyses. Using the reverse-phase HPLC the profile of sulfated disaccharides released by chondroitinase ABC from chondroitin/dermatan sulfates was estimated. Chondroitin/dermatan sulfates and hyaluronic acid were found in all samples. Propolis stimulated significant changes in the content of particular glycosaminoglycan types during burn healing. Glycosaminoglycans alterations after silver sulfadiazine application were less expressed. Propolis maintained high contribution of 4-O-sulfated disaccharides to chondroitin/dermatan sulfates structure and low level of 6-O-sulfated ones throughout the observed period of healing. Propolis led to preservation of significant contribution of disulfated disaccharides especially 2,4-O-disulfated ones to chondroitin sulfates/dermatan sulfates structure throughout the observed period of healing. Our findings demonstrate that propolis accelerates the burned tissue repair by stimulation of the wound bed glycosaminoglycan accumulation needed for granulation, tissue growth, and wound closure. Moreover, propolis accelerates chondroitin/dermatan sulfates structure modification responsible for binding growth factors playing the crucial role in the tissue repair.

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Molecular biology of wound healing

Cited by 33 publications

References 11 publications

The Review on Properties of Aloe Vera in Healing of Cutaneous Wounds

The Review on Properties of Aloe Vera in Healing of Cutaneous Wounds

Calendula officinalis stimulate proliferation of mouse embryonic fibroblasts via expression of growth factors TGFβ1 and bFGF

Propolis Induces Chondroitin/Dermatan Sulphate and Hyaluronic Acid Accumulation in the Skin of Burned Wound

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