Molecular Biology of Vitamin D Metabolism and Skin Cancer

Current progress in using vitamin D and its analogs for cancer prevention and treatment

“…It has recently been shown using the human adenocarcinoma cell line SW480 that the transcriptional activation of E-cadherin by 1,25(OH) 2 D 3 is dependent on a nongenomic pathway that involves an initial VDR-dependent Ca 2+ influx [61]. This transiently activates a key regulator of cytoskeleton dynamics and cell adhesion and migration, GTPase RhoA [62], and its immediate effector ROCK.…”

Physiological function of vitamin D3 in fish

“…In addition, VD 3 has hormone‐like activity that widely contributes to the maintenance of animal health. Studies in mammals over the past decade have confirmed that beyond bone mineralisation, VD 3 can also regulate nutritional metabolism and immune function to optimise resistance and responsiveness to bacterial and viral infections and cancers 8–16 . The VD endocrine system in fish appears to function similarly as in mammals 17 ; however, the function of VD 3 in fish and its mechanism of action are still relatively poorly studied compared with mammals.…”

“…Studies in mammals over the past decade have confirmed that beyond bone mineralisation, VD 3 can also regulate nutritional metabolism and immune function to optimise resistance and responsiveness to bacterial and viral infections and cancers. [8][9][10][11][12][13][14][15][16] The VD endocrine system in fish appears to function similarly as in mammals 17 ; however, the function of VD 3 in fish and its mechanism of action are still relatively poorly studied compared with mammals. This review presents a general picture of the possible physiological function of VD 3 in fish, especially in terms of fish growth, bone development, antioxidant status and immunity as well as lipid metabolism, and compares the differences in VD 3 metabolism between fish and mammals.…”