Molecular Behavior of Medicinals in Ground Mixtures with Microcrystalline Cellulose and Cyclodextrins

Nakai, Yusuke

doi:10.3109/03639048609048054

Cited by 23 publications

(2 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mechanochemical activation has been used for CDs complexation of drugs since 1986 [26]; steroid, such as methylhydroxyprogesterone complexes have been prepared [27]. Grinding treatments may dramatically enhance solubility and bioavailability of poorly water-soluble drugs [28] due to particle size reduction, higher surface area and porosity [29].…”

Section: Introductionmentioning

confidence: 99%

Efficient mechanochemical complexation of various steroid compounds with α-, β- and γ-cyclodextrin

et al. 2015

View full text Add to dashboard Cite

Mechanochemical technology enables solvent-free micronized solid dispersions and efficient molecular host-guest inclusion complexes to be formed in matrices which contain cyclodextrins (CDs). This type of complexation has been studied using α-, β- and γ-cyclodextrin with the dual aims of improving overall solubility and enhancing the bioavailability of common steroid compounds, such as cholic acids and β-sitosterols or lowering cholesterol content in products of animal origin. Several parameters have been studied and optimized: CD/compound molar ratio (1:1, 1:2, 2:1 and 3:1) in function of the cavity sizes of the three different CDs, milling time (from 5 to 40 min) and rotation speed (from 100 to 300 rpm). DSC (differential scanning calorimetry) analyses have revealed that inclusion complexes were efficiently formed after 40 min milling (200 rpm) for β-CD/cholesterol and β-CD/ugrsodeoxycholic acid (encapsulation efficiency 96% and 77% respectively). Besides steroid encapsulation/vehiculation, the mechanochemical technique may pave the way for new ideas in solventless steroid extraction from vegetal matrices with CDs.

show abstract

Section: Introductionmentioning

confidence: 99%

Efficient mechanochemical complexation of various steroid compounds with α-, β- and γ-cyclodextrin

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Several techniques have been successfully adopted to improve the dissolution rate of these drugs including solid dispersions with various carriers, [2][3][4][5] solid solutions, 6 co-grinding with certain carriers, 7 surface hydrophilization 8 and also inclusion complexation with βcyclodextrin and its derivatives has been reported to enhance the dissolution characteristics of a variety of poorly soluble drugs. [9][10][11][12] Surface adsorption is one of the methods used to reduce the particle size by increasing the surface area available to the dissolution medium.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Naproxen Adsorbate as an Attempt to Improve Drug Dissolution Characteristics

Ismail

Saleh

Khalaf

2004

Bulletin of Pharmaceutical Sciences. Assiut

View full text Add to dashboard Cite

Naproxen is a nonsteroidal anti-inflammatory drug which shows variable absorption and bioavailability due to its poor solubility. In this study we aimed to improve the dissolution rate of the drug by solvent deposition onto certain adsorbents including porous silica, Avicel and Bentonite. Physical mixtures of naproxen with the investigated adsorbents were also prepared. The molecular behavior of naproxen in the investigated systems were studied using infrared absorption spectra, differential scanning calorimetry and X-ray diffraction analysis. The dissolution rate of the drug was also investigated. The obtained results indicated that naproxen was transformed to the amorphous state in case of mixtures loaded with porous silica. This transformation resulted in a significant enhancement of the dissolution rates of the drug. In addition, it was noticed that, the drug: adsorbents weight ratio of the prepared mixtures influenced the drug dissolution rate enhancement. Accordingly, it can be concluded that, by increasing the weight ratio of the used adsorbent in the mixture, the larger the enhancement in the dissolution rate of naproxen will be obtained.

show abstract

Interaction of Piroxicam Polymorphs with β-Cyclodextrin in Ground Mixtures

Puttipipatkhachorn

Prasitporn

1996

Proceedings of the Eighth International Symposium on Cyclodextrins

View full text Add to dashboard Cite

Molecular Behavior of Medicinals in Ground Mixtures with Microcrystalline Cellulose and Cyclodextrins

Cited by 23 publications

References 28 publications

Efficient mechanochemical complexation of various steroid compounds with α-, β- and γ-cyclodextrin

Efficient mechanochemical complexation of various steroid compounds with α-, β- and γ-cyclodextrin

Preparation and Evaluation of Naproxen Adsorbate as an Attempt to Improve Drug Dissolution Characteristics

Interaction of Piroxicam Polymorphs with β-Cyclodextrin in Ground Mixtures

Contact Info

Product

Resources

About