The IR transmittance spectrum of an isotopic mixture of chlorodifluoromethane (CHF2Cl, Freon-22) with a 33% fraction of 13C and a natural ratio of chlorine isotopes was measured in the frequency range 1400-740 cm–1 with a resolution of 0.001 cm–1 at a temperature of 20C. An ab initio calculation of the structure and sextic potential energy surface and surfaces of the components of the dipole moment has been carried out by the the electronic quantum-mechanical method of Möller-Plesset, MP2/cc-pVTZ. Then the potential was optimized by replacing the harmonic frequencies with the frequencies calculated by the electronic method of coupled clusters, CCSD(T)/aug-cc-pVQZ. The fundamental and combination frequencies were calculated using the operator perturbation theory of Van Vleck (CVPTn) of the second and fourth order (n=2,4). Resonance effects were modeled using an additional variational calculation in the basis up to fourfold VCI excitation (4). The average prediction error for the fundamental frequencies of the 12C isotopologues was ~1.5 cm–1. The achieved accuracy made it possible to reliably predict the isotopic frequency shifts of the 13C isotopologues. It is shown that the strong Fermi resonance ν4/2ν6 dominates in the 12C isotopologues and is practically absent in 13C. The literature assumption [Spectrochim. Acta A, 44: 553] about the splitting of ν1 (CH) due to the resonance ν1/ν2+ν7+ν9 is confirmed. The coefficients of the polyadic quantum number are determined. The analysis made it possible to carry out a preliminary identification of the centers of the vibrational-rotational bands of isotopologues 13CHF235Cl и 13CHF237Cl in the spectrum of the mixture in preparation for individual analyzes of the vibrational-rotational structures of individual vibrational transitions.