Molecular Basis Supporting the Association of Talcum Powder Use with Increased Risk of Ovarian Cancer

Fletcher, N.M.; Harper, Amy; Memaj, Ira; Fan, Rong; Morris, Robert T.; Saed, Ghassan M.

doi:10.1007/s43032-020-00267-7

Cited by 6 publications

(4 citation statements)

References 23 publications

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“…Talc is not genotoxic. Mechanistic, pathology and animal model studies have not found evidence for a carcinogenic effect except studies reported strong association of epithelial ovarian cancer from perineal talc use [20][21][22][23][24][25]. Talc is a translucent mineral with a pearly luster.…”

Section: Covering Powermentioning

confidence: 99%

An Extensive Review of Face Powder Formulation Considerations

Mohiuddin¹

2019

JDD

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The face powder was demanded by many nations in the world in the beginning AD and in Asia white skin was believed to be the sign of aristocratism, membership of the elite, and yet, white color is the pure symbol of the internal beauty and nobility. In addition, some face powders are sold in varying specialty shades to suit different skin needs; for example, a face powder with a greenish tinge will minimize the appearance of redness, while a purple-tinted powder may help the appearance of sallow or yellow skin. There is a legitimate reason to use face powder, and the pharmacopeias prescribe them in the treatment of many skin affections. At all events the proper use of powder is beneficial, it lightly covers and unifies a complexion, hiding the ravages of time, improving even the beautiful face. Face powder comes in different shades to match varying skin tones, and it is a good idea to choose the skin tone that most closely matches the natural skin. This will help the makeup appear more natural; it should be virtually unnoticeable. It may be necessary to use different face powders for summer and winter, as the skin may become tanner in the summer, or drier and in need of extra moisture in the winter. They are of benefit in acne, freckles, sunburn and red nose. Beneath their attractive aspect and odor, face powders should be made by the perfumer to combine the qualities of an elegant cosmetic and therapeutic agent; they must primarily possess adherence, lightness and be transparent; secondly, they should be detergent and delicately absorbent in order to aid the natural functions of the skin, taking up the fatty matters not easily dislodged by water; they should also tend to increase the natural elasticity and regular functions of the skin.

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Section: Covering Powermentioning

confidence: 99%

An Extensive Review of Face Powder Formulation Considerations

Mohiuddin¹

2019

JDD

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“…It is widely speculated that trans-genital migration of talc powder through the fallopian tubes to the ovaries and peritoneum results in inflammation and a cascade of changes that result in carcinogenesis. 20,21 Talc fibers are found within normal ovaries and within ovarian cancer with "cosmetic" talc use 22,23 supporting this theory. A case series by Steffen et al reported 10 cases of patients with "cosmetic" talc exposure and serous ovarian cancer evaluated the surgical specimens as well as cosmetic talcum powder ) of women included as cases and controls (or cohort) who were exposed and not exposed are provided (excluding from the table women who had exposure to talcum powder at less than the highest exposure).…”

Section: Discussionmentioning

confidence: 84%

Association Between the Frequent Use of Perineal Talcum Powder Products and Ovarian Cancer: a Systematic Review and Meta-analysis

2022

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Background Risk of ovarian cancer in women with frequent perineal talcum powder product is not well understood. Prior systematic reviews focused on ever use. The purpose of this study is to estimate the association between frequent (at least 2 times per week) perineal talcum powder use and ovarian cancer. Methods A systematic review and meta-analysis was conducted according to meta-analysis of observational studies in epidemiology guidelines. Study protocol was prospectively registered at PROSPERO (registration number CRD42020172720). Searches were performed in PubMed, Embase, Web of Science, and Cochrane Central Register of Controlled Trials databases from their inception to August 2, 2021. Case-control and cohort studies were included if they reported frequent perineal talcum powder use and an adjusted odds ratio or hazard ratio for ovarian cancer. Review for inclusion, data extraction, and quality assessment (using the Newcastle-Ottawa Scale [NOS]) were performed independently by two reviewers. Pooled adjusted odds ratios with 95% confidence intervals were generated from the random effects model. Heterogeneity was quantified with I2 statistic. Funnel plot and Eger’s test were performed to assess publication bias. Subgroup and sensitivity analyses were performed for testing the robustness of the overall findings. Results Initial database searches returned 761 unique citations and after review, eleven studies describing 66,876 patients, and 6542 cancers were included (Cohen’s κ = 0.88). Publication quality was high (median NOS = 8, range: 4 to 9). Frequent talcum powder use was associated with an elevated risk of ovarian cancer (adjusted pooled summary odds ratio 1.47 (95% CI 1.31, 1.65, P<0.0001). There was no evidence of bias and low heterogeneity (I2= 24%, P=0.22). There was no meaningful difference limiting analysis to publications with a NOS quality score of 8 or 9 or limiting studies based on study design. Conclusions This review suggests an increased risk of ovarian cancer associated with frequent perineal powder exposure of 31–65%.

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“…Her daily ingestion of talc may have been cocarcinogenic. 7 Her young age and disease chronicity enabled her to be well compensated, despite the minimal perfusion of her left lung. Initial pulmonary endarterectomy, an effective treatment for CTEPH, 6,9 enabled the safe and timely curative resection of her abdominal malignancy days later.…”

Section: Discussionmentioning

confidence: 99%

“…A 25-year-old African American woman weighing 92 kg (body mass index, 34.6) presented at another hospital with shortness of breath at rest (New York Heart Association [NYHA] functional class IV), hypoxia, and pleuritic chest pain after an extended period of travel. Her medical history included sickle cell trait, iron deficiency anemia with talc pica (a possible cocarcinogen), 7 and multiple upper respiratory infections refractory to both antibiotic and steroid therapy. Her familial history included hypertension, and she had a 50-year-old second-degree relative with thyroid cancer who had no identifiable genetic syndromes.…”

Section: Case Reportmentioning

confidence: 99%

Trousseau Syndrome in a 25-Year-Old Woman with Occult Colon Malignancy, Lynch Syndrome, and Chronic Thromboembolic Pulmonary Hypertension

Matthews

Madison

Zhang

et al. 2022

Texas Heart Institute Journal

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We present a rare case of thrombosis associated with an occult colon malignancy (Trousseau syndrome) in a 25-year-old woman who also presented with previously unidentified Lynch syndrome and acute-on-chronic thromboembolic pulmonary hypertension. Staged treatment included bilateral pulmonary endarterectomy under deep hypothermic circulatory arrest, followed 11 days later by laparoscopic subtotal colectomy and creation of a primary anastomosis. The patient tolerated both procedures well and recovered normal functional status. Final pathologic analysis of the resected colon mass revealed a pT3N0, stage IIA adenocarcinoma; no adjuvant therapy was administered. At her one-year follow-up visit, the patient was cancer-free, remained on lifelong apixaban anticoagulation, and was undergoing routine monitoring and genetic counseling. This case highlights the need for multidisciplinary management of a patient with severe chronic thromboembolic pulmonary hypertension and a concomitant malignancy.

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Molecular Basis Supporting the Association of Talcum Powder Use with Increased Risk of Ovarian Cancer

Cited by 6 publications

References 23 publications

An Extensive Review of Face Powder Formulation Considerations

An Extensive Review of Face Powder Formulation Considerations

Association Between the Frequent Use of Perineal Talcum Powder Products and Ovarian Cancer: a Systematic Review and Meta-analysis

Trousseau Syndrome in a 25-Year-Old Woman with Occult Colon Malignancy, Lynch Syndrome, and Chronic Thromboembolic Pulmonary Hypertension

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