Molecular basis of neural repair mechanisms

Müller, Hans‐Werner; Sendtner, Michael; Bahr, Matthias J.

doi:10.1007/s00441-012-1448-y

Cited by 2 publications

(1 citation statement)

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“…With regard to humans, one must keep in mind that though loss of neuronal mitosis severely compromises brain repair our species benefits from a multitude of selective and delicate mechanisms of plasticity capable of reestablishing at least some function after damage. Such mechanisms include DNA repair (Canugovi, Misiak, Ferrarelli, Croteau, & Bohr, 2013), steroid (Petrovska, Dejanova, & Jurisic, 2012) and neurosteroid (Guennoun et al, 2015) neuroprotection, glial and stem cell action and signaling (Selvaraj, Jiang, Chechneva, Lo, & Deng, 2012), axonal regeneration (Müller, Sendtner, & Bähr, 2012), receptor trafficking (Zhong & Zou, 2014), functional cognitive reallocation (Borgstein & Grootendorst, 2002) and many others (see Doidge, 2007, for a wide ranging popularization of human brain plasticity). However, these mechanisms add to the already heavy load of energy requirement, to mention but that one, of complex brains.…”

Section: Neuronal Consciousness and Its Assorted Biological Costsmentioning

confidence: 99%

Biological costs of the evolution of adaptive behavior and consciousness.

Braun¹

2015

Psychology of Consciousness: Theory, Research, and Practice

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This essay is an attempt to account for adaptive behavior and consciousness in the most concrete manner possible, addressing their embodiments throughout phylogenesis. The focus is on their biological costs, not particularly their benefits. The goal is to understand consciousness biologically while eschewing mentalism, anthropocentrism, and teleonomic enthusiasm. Throughout evolution adaptive behavior and consciousness have been embodied as catalytic molecular cascades, no more, no less. As these cascades became increasingly complex in particular ecological niches many new biological problems accrued for living organisms. Evolutionary resolution of these problems has been varied, incomplete, and fragile, including in the human species.

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