Molecular Basis of Natural Variation in Photoperiodic Flowering Responses

Bao, Shengjie; Hua, Changmei; Huang, Geng-Qing; Peng, Cheng; Gong, Xun; Shen, Lisha; Yu, Hao

doi:10.1016/j.devcel.2019.05.018

Cited by 53 publications

(48 citation statements)

References 56 publications

(90 reference statements)

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“…Besides sequestering FT activators, DELLA can also suppress FT expression through interacting with FT suppressors (Figure B). One such example is MYC3, a bHLH transcription factor, which directly represses FT in a DELLA‐dependent manner (Bao et al ). MYC3 is highly expressed in rosette leaves, with higher expression level and protein abundance under SDs than LDs.…”

Section: Gibberellin Signaling Pathwaymentioning

confidence: 99%

“…Meanwhile, as the MYC3 binding site on FT locates in a region that has been shown to correlate with natural differences in photoperiodic flowering response among different Arabidopsis accessions (Bao et al ), it would be interesting to further investigate whether the differences of GA response in various accessions correlate with different binding affinities between MYC3 and FT promoters in these accessions. Moreover, this MYC3 binding site on FT is located within the region that is required for chromatin looping mediated by the above‐mentioned CO/NF‐YB complex for full activation of FT expression (Cao et al ; Bao et al ). It is promising to check the correlation between these two regulatory modules, DELLA‐MYC3 and DELLA‐CO/NF‐YB both involved in GA‐mediated FT regulation.…”

Section: Gibberellin Signaling Pathwaymentioning

confidence: 99%

“…Thus, the DELLA‐JAZ1‐MYC2 module likely exists for flowering time regulation. Furthermore, DELLAs stabilize MYC3, another JA pathway regulator that also interacts with JAZs (Cheng et al ; Fernandez‐Calvo et al ) and represses FT expression (Bao et al ). There results suggest that direct or indirect modulation of MYC function by DELLAs, possibly engaging JA signaling, mediates FT expression in leaves under both LDs and SDs.…”

Section: Gibberellin Signaling Pathwaymentioning

confidence: 99%

“…The floral integrator FT has been extensively studied as part of the mobile floral promotive signal known as “florigen” (Corbesier et al ; Kobayashi and Weigel ). FT is highly conserved across angiosperm species and its gene expression in Arabidopsis is mainly activated by CONSTANS (CO), but suppressed by other repressors, such as MYC3 in the GA signaling pathway, in leaves (Samach et al ; Suárez‐López et al ; An et al ; Valverde et al ; Bao et al ). Its protein is mediated by multiple regulators to move via the phloem into the shoot apex (Liu et al , ; Zhu et al ; Liu et al ), where it promotes the expression of another floral integrator SOC1 and the floral meristem identity gene AP1 (Wigge et al ; Notaguchi et al ).…”

Section: Introductionmentioning

confidence: 99%

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New insights into gibberellin signaling in regulating flowering in Arabidopsis

Bao

Hua

Shen

et al. 2020

JIPB

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In angiosperms, floral transition is a key developmental transition from the vegetative to reproductive growth, and requires precise regulation to maximize the reproductive success. A complex regulatory network governs this transition through integrating flowering pathways in response to multiple exogenous and endogenous cues. Phytohormones are essential for proper plant developmental regulation and have been extensively studied for their involvement in the floral transition. Among various phytohormones, gibberellin (GA) plays a major role in affecting flowering in the model plant Arabidopsis thaliana. The GA pathway interact with other flowering genetic pathways and phytohormone signaling pathways through either DELLA proteins or mediating GA homeostasis. In this review, we summarize the recent advances in understanding the mechanisms of DELLA-mediated GA pathway in flowering time control in Arabidopsis, and discuss its possible link with other phytohormone pathways during the floral transition.

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Section: Gibberellin Signaling Pathwaymentioning

confidence: 99%

Section: Gibberellin Signaling Pathwaymentioning

confidence: 99%

Section: Gibberellin Signaling Pathwaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

New insights into gibberellin signaling in regulating flowering in Arabidopsis

Bao

Hua

Shen

et al. 2020

JIPB

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211

149

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“…The key regulatory step in the JA pathway is the hormone-triggered formation of a complex between the E3 ligase SCF COI1 and JAZ repressors that are bound to the master TF MYC2. This results in degradation of JAZ repressors and permits the activity of a master regulatory bHLH transcription factor MYC2, accompanied by MYC3, MYC4, MYC5 and numerous other transcription factors, all of which have distinct but overlapping roles in driving JA-responsive gene expression (Song et al, 2017, Schweizer et al, 2013b, Fernandez-Calvo et al, 2011, Lorenzo et al, 2004, Bao et al, 2019). The result is a cascade of JA-induced genome reprogramming to modulate plant behavior such as plant immune responses (Du et al, 2017, Hickman et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Integrated Multi-omic Framework of the Plant Response to Jasmonic Acid

Zander

Lewsey

Clark

et al. 2019

Preprint

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27Understanding the systems-level actions of transcriptional responses to hormones provides 28 insight into how the genome is reprogrammed in response to environmental stimuli. Here, we 29 investigate the signaling pathway of the hormone jasmonic acid (JA), which controls a plethora of 30 critically important processes in plants and is orchestrated by the transcription factor MYC2 and 31 its closest relatives in Arabidopsis thaliana. We generated an integrated framework of the 32 response to JA that spans from the activity of master and secondary-regulatory transcription 33 factors, through gene expression outputs and alternative splicing to protein abundance changes, 34 protein phosphorylation and chromatin remodeling. We integrated time series transcriptome 35 analysis with (phospho)proteomic data to reconstruct gene regulatory network models. These 36 enable us to predict previously unknown points of crosstalk from JA to other signaling pathways 37 and to identify new components of the JA regulatory mechanism, which we validated through 38 targeted mutant analysis. These results provide a comprehensive understanding of how a plant 39 hormone remodels cellular functions and plant behavior, the general principles of which provide 40 a framework for analysis of cross-regulation between other hormone and stress signaling 41 pathways. 42 43 44 45 46 47 48 49 50 51 52 5 2004, Fernandez-Calvo et al. , 2011). myc3 and myc4 single mutants behave like wildtype with 104 regards to JA-induced root growth inhibition. However, in combination with the myc2 mutant, 105 myc2 myc3 double mutants exhibit an increased JA hyposensitivity, almost as pronounced as in 106 myc2 myc3 myc4 triple mutants (Fernandez-Calvo et al., 2011). We consequently selected MYC3 107 for an in-depth analysis. 108In order to better understand how the master TFs MYC2 and MYC3 control the JA-109 induced transcriptional cascade, we determined their genome-wide binding sites using chromatin 110 immunoprecipitation sequencing (ChIP-seq). Four biological replicates of JA-treated (2 hours) 111 three-day-old etiolated Arabidopsis seedlings that express a native promoter-driven and epitope 112 (YPet)-tagged version of MYC2 and three biological replicates of MYC3 (Col-0 MYC2::MYC2-113 Ypet, Col-0 MYC3::MYC3-Ypet) were used (Gimenez-Ibanez et al., 2017). The genome-wide 114distributions of MYC2 and MYC3 binding sites were highly similar (Fig. 1c, d). We identified 6,736 115 MYC2 and 3,982 MYC3 binding sites of high confidence, equating to 6,178 MYC2 and 4,092

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Regulation by FLOWERING LOCUS T and TERMINAL FLOWER 1 in Flowering Time and Plant Architecture

Xuan

Jiang

et al. 2021

Small Structures

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The conversion from vegetative to inflorescence shoot apical meristem is one of the key developmental switches in flowering plants. This transition is modulated by various environmental and endogenous stimuli and controlled by sophisticated regulatory networks. Regulation of flowering time and inflorescence architecture has a great impact on plant reproductive success and significantly influences plant biomass and fitness. FLOWERING LOCUS T (FT), a mobile protein identified as a major component of florigen, promotes the transition to flowering, whereas its homologous protein TERMINAL FLOWER 1 (TFL1) functions oppositely. Studies in various species reveal that FT and TFL1 play universal and multifaceted roles in a wide range of developmental processes in plants. Hence, modulations of FT/TFL1 and their regulatory pathways have a considerable impact on plant development and crop domestication. Herein, an overview of the molecular basis underlying the regulation of FT/TFL1 expression and modulation of their protein trafficking and the relevant mechanisms in flowering time control and meristem development is provided. Whenever applicable, their functional conservation and divergence in various plant species are also discussed.

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Molecular Basis of Natural Variation in Photoperiodic Flowering Responses

Cited by 53 publications

References 56 publications

New insights into gibberellin signaling in regulating flowering in Arabidopsis

New insights into gibberellin signaling in regulating flowering in Arabidopsis

Integrated Multi-omic Framework of the Plant Response to Jasmonic Acid

Regulation by FLOWERING LOCUS T and TERMINAL FLOWER 1 in Flowering Time and Plant Architecture

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