Molecular basis for affected cartilage formation and bone union in fracture healing of the streptozotocin-induced diabetic rat

Impact of type 2 diabetes on the gene expression of bone-related factors at sites receiving dental implants

“…Additionally, no clinical study has used the alveolar bone tissue from T2DM patients to investigate the expression of bone-related markers isolated from other events, such as the repair of critical-sized bone defects and other healing models. Additionally, bone biopsies are rarely undertaken in humans and most investigations analysing diabetic bone tissue have been performed in animal studies, 22,24,37,38 or have evaluated circulating bone-related markers in humans. 18,19,39 This investigation elucidated possible molecular mechanisms through which T2DM may interfere with bone tissue repair around implants under hyperglycaemic conditions.…”

Impact of Diabetes on Fracture Healing

“…Smaller cartilaginous calluses were reported during healing in streptozotocin-induced diabetic rats, which were accompanied by reduced proliferation of chondroprogenitor cells and chondrocytes in the early stages of healing. 60 At the molecular level, there were low levels of Type II collagen, Type X collagen, and osteopontin. 60 Type X collagen expression, chondrocyte maturation, and hypertrophy were also delayed in diabetic experimental models with an associated decrease in mechanical strength.…”

Implant Healing in Experimental Animal Models of Diabetes

“…46 The mechanism of delayed bone healing in diabetic animal models has yet to be fully elucidated, but impaired osteoblast 47 and osteoclast 48 function as well as altered chondrogenesis 49 have been proposed.…”