Impact of type 2 diabetes on the gene expression of bone-related factors at sites receiving dental implants

Conte, Alexandre; Ghiraldini, Bruna; Casarin, Renato Corrêa Viana; Casati, Márcio Zaffalon; Pimentel, Suzana Peres; Cirano, Fabiano Ribeiro; Duarte, PM; Ribeiro, Fernanda Vieira

doi:10.1016/j.ijom.2015.06.001

Cited by 28 publications

(29 citation statements)

References 41 publications

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“…The findings of the present observational study concur with those of several earlier studies, which demonstrated that hyperglycemic state leads to alterations in bone functions. 18,19,20,21 Other retrospective studies have also recognized pathological changes in bone function related to chronic hyperglycemia. 22,23 The present study observed that PIBL was high in T2DM patients in relation to mean HbA1c levels of 8.2%.…”

Section: Discussionmentioning

confidence: 99%

Stability and bone loss around submerged and non-submerged implants in diabetic and non-diabetic patients: a 7-year follow-up

Zahrani

Mutairi

2018

Braz. oral res.

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Stability and bone loss around submerged and non-submerged implants in diabetic and non-diabetic patients: a 7-year follow-up Abstract: To evaluate peri-implant bone loss (PIBL) and stability around submerged and non-submerged dental implants in patients with and without type 2 diabetes mellitus (T2DM). Thirty-five T2DM and non-diabetic (NT2DM) patients were included in this study. Demographic data were recorded using a questionnaire and PIBL was measured on digital radiographs. Resonance frequency analysis (RFA) was carried out for each implant at the time of fixture placement and at 3 months in both groups. P values less than 0.05 were considered statistically significant. One hundred and eighteen dental implants with a mean height of 10 to 12 mm and 3.3 to 4.1 mm in diameter were placed. The comparison of the mean RFA values at baseline and at 3 months was statistically significant (p = 0.008) in T2DM patients. The inter-group mean RFA values at baseline and at 3 months were not significant (p > 0.05). PIBL was significantly high in T2DM as compared to NT2DM patients at each follow-up (p < 0.05). At 2, 3, and 7 years, non-submerged dental implants showed significantly high PIBL in T2DM patients as compared to NT2DM individuals (p<0.05). The results of the present clinical study demonstrate increased PIBL around non-submerged single-tooth implant-supported restorations in T2DM patients, which may be due to the immune inflammatory status.

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Section: Discussionmentioning

confidence: 99%

Stability and bone loss around submerged and non-submerged implants in diabetic and non-diabetic patients: a 7-year follow-up

Zahrani

Mutairi

2018

Braz. oral res.

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“…9,11,[19][20][21][22][23][24] Thus, 14 studies published between 2000 and 2015 were included in this systematic review. 3,10,[25][26][27][28][29][30][31][32][33][34][35][36] The article search and selection process is shown in Fig. 1.…”

Section: Literature Searchmentioning

confidence: 99%

“…29,33 A marginal bone loss assessment was conducted in five studies using peri-apical and/or panoramic radiographs, in which the implant platform in relation to the alveolar bone crest was used as the reference. 26,29,[32][33][34] Antibiotic medication was administered in seven studies, either before 35,36 or after 10,27,29,32,34 surgery. Six studies reported prescribing chlorhexidine mouthwash postoperatively.…”

Section: Study Characteristicsmentioning

confidence: 99%

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The impact of diabetes on dental implant failure: a systematic review and meta-analysis

Moraschini

Barboza

Peixoto

2016

International Journal of Oral and Maxillofacial Surgery

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“…From the results, they concluded that in patients undergoing dental implants and having a long-term history of cigarette smoking should be made aware of consequences and effect of smoking on the desorption of bone around the peri-implant area. Conte et al 25 assessed the effect of diabetes on the bone-related gene expression in the areas receiving dental implants. They evaluated a total of 54 patients and observed a low quantity of bone sialoprotein, type I collagen in patients with poorly controlled diabetes.…”

Section: Discussionmentioning

confidence: 99%

Intricate Assessment and Evaluation of Long-term Implant Success as affected by Clinicomicrobial and Salivary Diagnostics in Type II Diabetic Patients: A Longitudinal Study

Raghav

Alqahtani

Albaker

et al. 2017

The Journal of Contemporary Dental Practice

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Introduction Replacement of missing teeth by dental implants is one of the most common methods employed these days. Because of significant advancement in the design of implants and modifications in the procedure of dental implant surgery, the survival rate of the dental implants has reached up to approximately 95%. Osseointegration is one of the important factors affecting the survival of dental implants. Apart from these, the body's physiologic alterations can also predispose the dental implants for failure. Diabetes is one such metabolic disease characterized by abnormal or delayed wound healing. Hence, we assessed the clinicomicrobial and salivary profile of diabetic patients undergoing rehabilitation by dental implants. Materials and methods This study included diabetic patients who underwent dental implant surgeries for prosthetic rehabilitation. Follow-up records of the patients’ up to 1 year were maintained. Various clinicoradiographic and periodontal parameters were measured at various time intervals during follow-up time; 25 mL of salivary and blood sample was taken from all the subjects and was sent to the laboratories for assessment of various salivary biomarkers. All the results were analyzed by Statistical Package for the Social Sciences software. Results The mean level of interleukin-â at baseline time was found to be 2.38 and 2.21 in diabetic group and control group respectively. While comparing the levels of osteoprotegerin in both study groups, a significant correlation was obtained. In diabetic and control group, 62 and 61 years was the mean age of the patients respectively. No significant correlation was obtained while comparing the microbial flora of diabetic and control group. Conclusion In both diabetic and nondiabetic patients, similar microbial, salivary marker, and clinicoradiological patterns were seen. Clinical significance Diabetic patients who maintain their body's metabolic rate show similar success rate of dental implants as seen in nondiabetic patients. How to cite this article Raghav D, Alqahtani F, Albaker FJ, Bhagat TV, Kola Z. Intricate Assessment and Evaluation of Long-term Implant Success as affected by Clinicomicrobial and Salivary Diagnostics in Type II Diabetic Patients: A Longitudinal Study. J Contemp Dent Pract 2017;18(5):405-409.

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Impact of type 2 diabetes on the gene expression of bone-related factors at sites receiving dental implants

Cited by 28 publications

References 41 publications

Stability and bone loss around submerged and non-submerged implants in diabetic and non-diabetic patients: a 7-year follow-up

Stability and bone loss around submerged and non-submerged implants in diabetic and non-diabetic patients: a 7-year follow-up

The impact of diabetes on dental implant failure: a systematic review and meta-analysis

Intricate Assessment and Evaluation of Long-term Implant Success as affected by Clinicomicrobial and Salivary Diagnostics in Type II Diabetic Patients: A Longitudinal Study

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