“…In the solved structures of bPBPs (Contreras-Martel, Dahout-Gonzalez, Martins, Kotnik, & Dessen, 2009;Han et al, 2010;Powell, Tomberg, Deacon, Nicholas, & Davies, 2009), this region consists of two interacting subdomains connected by a third subdomain forming a hinge that sits just underneath the catalytic TP domain. In a recently solved structure of an MreC-PBP2 complex from Helicobacter pylori, MreC interacts with the pedestal domain of PBP2 and in doing so causes its two interacting subdomains to swing open (Contreras-Martel et al, 2017) (Figure 2C). The alterations in PBP2 that suppress the MreC defects are not predicted to be at locations directly involved in the PBP2-MreC interface.…”