Molecular and morphometric analysis of the rat ventral prostate injected with leptin

Alves-Pereira, Jorge Luiz; Colli, Sicilia; Marques, Durval Santos; Sampaio, Francisco J.B.; Ramos, Cristiane F.

doi:10.1016/j.regpep.2012.02.002

Cited by 10 publications

(13 citation statements)

References 40 publications

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“…These animals also presented high leptin levels and an increase of the Ob-R expression in the testis, possibly increasing the testis response to leptin what would result in a decrease in testosterone serum biosynthesis. Another possibility is the fact that leptin is known to stimulate the aromatase enzyme 19 . Our results show that this protein expression was increased by maternal caffeine administration reinforcing a direct effect of the hormone in the testis.…”

Section: Discussionmentioning

confidence: 99%

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The testis of the mice C57/BL6 offspring in adulthood have alterations due to maternal caffeine consumption

et al. 2014

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PURPOSE:To investigate the effects of the maternal caffeine consumption during pregnancy to adult male testis mice offspring. METHODS:Twenty pregnant mice were divided into control group (c) and caffeine group (cf). dams received daily saline or 20 mg/kg of caffeine subcutaneously. Male offspring were monitored daily until 13 th week. The testis were used to evaluate both the proliferation (pcna) and apoptosis (bax); leptin receptor (ob-r); aromatase; follicle stimulating hormone (fshr), luteinizing hormone (lhr) and androgen receptors (ar); steroidogenic acute regulatory protein (star); vascular endothelial growth factor (vegf) and estrogen receptors (erα and erβ) by western blotting. Serum concentrations of testosterone, estradiol and leptin were measured. RESULTS:There was a significant reduction in food intake and the body mass gain (p<0.05) in the cf ; pcna (p=0.01), fshr (p=0.02), star (p=0.0007), vegf (p=0.009), ar (p=0.03) in the cf. while an increase were note in bax (p=0.01), ob-r (p=0.02), lhr (p=0.04) and in the aromatase (p=0.03) in the cf. only erα and erβ were not changed by maternal caffeine. The serum testosterone levels in the cf offspring were 90% lower than in the c offspring (p=0.04). CONCLUSION:Maternal caffeine consumption has a role and alters the testis of the offspring in adulthood.

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Section: Discussionmentioning

confidence: 99%

“…However this autoregulation seems to be tissue specific since in the prostate leptin increases the expression of Ob-R 19 . In the present study, the maternal caffeine intake disrupt the autoregulation process since the CF offspring presented high levels of serum leptin and a concomitant increase in the leptin receptor expression.…”

Section: Discussionmentioning

confidence: 99%

The testis of the mice C57/BL6 offspring in adulthood have alterations due to maternal caffeine consumption

et al. 2014

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“…Leptin may also play an important role in such association owing to its mitotic and antiapoptotic effect. It has been demonstrated that leptin promotes prostatic cell proliferation and, as a consequence, gland weight . Moreover, insulin resistance promotes an increase in cell proliferation of the prostatic epithelium .…”

Section: Discussionmentioning

confidence: 99%

“…It has been demonstrated that leptin promotes prostatic cell proliferation and, as a consequence, gland weight. 27 Moreover, insulin resistance promotes an increase in cell proliferation of the prostatic epithelium. 9 Oxidative stress can cause atherosclerosis and then fibrosis in smooth muscle of prostatic arterioles, increasing the weight of the gland.…”

Section: Discussionmentioning

confidence: 99%

Beneficial effects of lipidic extracts of saladette tomato pomace and Serenoa repens on prostate and bladder health in obese male Wistar rats

et al. 2017

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These findings indicated impaired contractility and hyperplasia in the prostate and bladder of obese rats induced by high sucrose. STP and SR could enhance prostate function by reducing contractility and hyperplasia and improve smooth muscle fiber structure and decrease cell proliferation in the bladder, suggesting their possible health-beneficial effects on lower urinary tract symptoms. © 2017 Society of Chemical Industry.

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“…This hormone is related to energy balance and food intake and its function is well established (Havel, 2000). However, in the past few years the presence of both leptin protein and messenger RNA (mRNA) have been described in different reproductive tissues (da Silveira Cavalcante et al, 2009;Rago et al, 2009;Alves-Pereira et al, 2012;Gombar & Ramos, 2013). The outcome that correlates leptin and reproduction are new concerning epididymis.…”

Section: Introductionmentioning

confidence: 99%

Leptin and Leptin Receptor are Expressed only in Clear Cells of Rat Epididymis Epithelia

Gombar

Ramos

2017

Int. J. Morphol.

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leptin receptor are expressed only in clear cells of rat epididymis epithelia. Int. J. Morphol., 35(4):1303Morphol., 35(4): -1308Morphol., 35(4): , 2017. SUMMARY:Leptin is a 16 kilodaltons hormone secreted by adipose tissue and in the past few years it has been related to the reproductive system regulation. Leptin and its receptor (OBR) have been described in several reproductive organs and in different species but, in epididymis, there is still a lack of information. The aim of this work is to establish if leptin and its receptor are present on epididymis and where the production is occurring. At mRNA level the cauda portion showed a high expression of leptin (p<0.025) and OBRa (p<0.002) while at protein level the OBR expression was lower in cauda region (p<0.025) and leptin was not detected. The ratio between OBRa and OBRb was higher in both regions despite its total amount. By immunohistochemistry leptin and OBR were detected on epididymis epithelia, restricted to clear cells (CC). After efferent duct ligation (EDL) a decrease on leptin staining on CC was observed, suggesting that despite of epididymis production, most of leptin source may probably come from testis. Our results show that leptin and OBR, both mRNA and protein, are present on epididymis and exclusively in CC, suggesting that this tissue is responsive to the hormone and may have an important role on CC regulation.

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Molecular and morphometric analysis of the rat ventral prostate injected with leptin

Cited by 10 publications

References 40 publications

The testis of the mice C57/BL6 offspring in adulthood have alterations due to maternal caffeine consumption

The testis of the mice C57/BL6 offspring in adulthood have alterations due to maternal caffeine consumption

Beneficial effects of lipidic extracts of saladette tomato pomace and Serenoa repens on prostate and bladder health in obese male Wistar rats

Leptin and Leptin Receptor are Expressed only in Clear Cells of Rat Epididymis Epithelia

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