Molecular and Genetic Characterization of the Drosophila tartan Gene

Chang, Zhen; Price, B D; Bockheim, S.; Boedigheimer, Michael; Smith, Roger K.; Laughon, Allen

doi:10.1006/dbio.1993.1310

Cited by 67 publications

(58 citation statements)

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“…LRRs have been identi®ed as the high a nity binding sites in the receptors for neurotrophin (Windisch et al, 1995a,b) and gonadotrophin (Braun et al, 1991) as well as in the proteoglycans (Svensson et al, 1995). A number of LRR-containing proteins such as slit, toll, tartan, connectin and the Trk family of proteins are involved in the development and di erentiation of the neural system (Chang et al, 1993;Halfon et al, 1995;Meakin and Shooter, 1992;Nose et al, 1997;Rothberg et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors

1998

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Loss of heterozygosity for 10q23 ± 26 is seen in over 80% of glioblastoma multiforme tumors. We have used a positional cloning strategy to isolate a novel gene, LGI1 (Leucine-rich gene ± Glioma Inactivated), which is rearranged as a result of the t(10;19)(q24;q13) balanced translocation in the T98G glioblastoma cell line lacking any normal chromosome 10. Rearrangement of the LGI1 gene was also detected in the A172 glioblastoma cell line and several glioblastoma tumors. These rearrangements lead to a complete absence of LGI1 expression in glioblastoma cells. The LGI1 gene encodes a protein with a calculated molecular mass of 60 kD and contains 3.5 leucine-rich repeats (LRR) with conserved¯anking sequences. In the LRR domain, LGI1 has the highest homology with a number of transmembrane and extracellular proteins which function as receptors and adhesion proteins.LGI1 is predominantly expressed in neural tissues, especially in brain; its expression is reduced in low grade brain tumors and it is signi®cantly reduced or absent in malignant gliomas. Its localization to the 10q24 region, and rearrangements or inactivation in malignant brain tumors, suggest that LGI1 is a candidate tumor suppressor gene involved in progression of glial tumors.

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Section: Discussionmentioning

confidence: 99%

A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors

1998

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“…For example connectin functions in neuromuscular junction formation (Nose et al, 1992), slit plays a role in axon development (Rothberg et al, 1990), chaoptin is involved in photoreceptor-cell development (Krantz and Zipursky, 1990) and tartan plays a role in neural and muscle development (Chang et al, 1993). In the vertebrate nervous system, several molecules have been studied.…”

Section: Discussionmentioning

confidence: 99%

GAC1, a new member of the leucine-rich repeat superfamily on chromosome band 1q32.1, is amplified and overexpressed in malignant gliomas

et al. 1998

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We have used two-dimensional electrophoresis of enzyme-digested genomic DNA to identify a novel gene GAC1, which maps at 1q32.1 and which is overexpressed in malignant gliomas in which it is ampli®ed. GAC1 encodes a protein which belongs to the leucine-rich repeat superfamily. Ampli®cation and overexpression of GAC1 was demonstrated in two of eight tumors where ampli®cations were previously evidenced by comparative genomic hybridization (one glioblastoma multiforme and one anaplastic astrocytoma), and in one of eight unselected glioblastomas multiforme. GAC1 exhibits sequence homology with other proteins which function as cell-adhesion molecules or as signal transduction receptor and is a likely candidate for the target gene in the 1q32.1 amplicon in malignant gliomas.

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“…4G and Fig. 5F) (Chang et al, 1993) both show broad neuroectodermal expression along the entire AP axis. In addition, TC014658/Tctartan is upregulated in a wedge-shaped region of the head anlage.…”

Section: Fate Shift Of Knockdown Embryos Is Predictive For the Expresmentioning

confidence: 93%

Genome wide identification ofTriboliumdorsoventral patterning genes

et al. 2016

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The gene regulatory network controlling dorsoventral axis formation in insects has undergone drastic evolutionary changes. In Drosophila, a stable long-range gradient of Toll signalling specifies ventral cell fates and restricts BMP signalling to the dorsal half of the embryo. In Tribolium, however, Toll signalling is transient and only indirectly controls BMP signalling. In order to gain unbiased insights into the Tribolium network, we performed comparative transcriptome analyses of embryos with various dorsoventral pattering defects produced by parental RNAi for Toll and BMP signalling components. We also included embryos lacking the mesoderm ( produced by Tctwist RNAi) and characterized similarities and differences between Drosophila and Tribolium twist loss-of-function phenotypes. Using stringent conditions, we identified over 750 differentially expressed genes and analysed a subset with altered expression in more than one knockdown condition. We found new genes with localized expression and showed that conserved genes frequently possess earlier and stronger phenotypes than their Drosophila orthologues. For example, the leucine-rich repeat (LRR) protein Tartan, which has only a minor influence on nervous system development in Drosophila, is essential for early neurogenesis in Tribolium and the Tc-zinc-finger homeodomain protein 1 (Tc-zfh1), the orthologue of which plays a minor role in Drosophila muscle development, is essential for maintaining early Tc-twist expression, indicating an important function for mesoderm specification.

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Molecular and Genetic Characterization of the Drosophila tartan Gene

Cited by 67 publications

References 0 publications

A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors

A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors

GAC1, a new member of the leucine-rich repeat superfamily on chromosome band 1q32.1, is amplified and overexpressed in malignant gliomas

Genome wide identification ofTriboliumdorsoventral patterning genes

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