volume 16, issue 23, P2997-3002 1998
DOI: 10.1038/sj.onc.1201828
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Abstract: We have used two-dimensional electrophoresis of enzyme-digested genomic DNA to identify a novel gene GAC1, which maps at 1q32.1 and which is overexpressed in malignant gliomas in which it is ampli®ed. GAC1 encodes a protein which belongs to the leucine-rich repeat superfamily. Ampli®cation and overexpression of GAC1 was demonstrated in two of eight tumors where ampli®cations were previously evidenced by comparative genomic hybridization (one glioblastoma multiforme and one anaplastic astrocytoma), and in one …

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