Molecular and functional characterization of bovine β-defensin-1

Aono, Shelly; Li, Changqing; Zhang, Guolong; Kemppainen, Robert J.; Gard, J. A.; Lu, Wuyuan; Hu, Xueyou; Schwartz, Dean D.; Morrison, Edward E.; Dykstra, Christine C.; Shi, Jishu

doi:10.1016/j.vetimm.2006.05.002

Cited by 24 publications

(10 citation statements)

References 30 publications

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“…Stimulation of cultured chicken vaginal cells with S. enteriditis or LPS increased levels of AvBD1 to -3 within 24 h. The importance of bdefensins in the protection of the mammalian male and female reproductive tracts is well established. Abundant expression of multiple b-defensin genes in the male (Palladino et al, 2003;Patil et al, 2005;Sang et al, 2005Sang et al, , 2006Yamamoto and Matsui, 2002) and female (Aono et al, 2006;Quayle et al, 1998;Valore et al, 1998) reproductive tracts has been reported. The male reproductive system is largely devoid of an adaptive immune system and is therefore depending on an effective innate immune system to prevent infection that may affect temporary or permanent fertility (Patil et al, 2005).…”

Section: Urogenital Tractmentioning

confidence: 99%

Avian defensins

Dijk

Veldhuizen

Haagsman

2008

Veterinary Immunology and Immunopathology

181

149

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Modulation of defensin expression may be one way to improve animal health and to reduce zoonotic diseases. Defensins are small, cationic, and amphipathic cysteine-rich antibiotic peptides found in plants, insects, mammals and birds. Whereas alpha- and theta-defensins appear to be absent in birds, several beta-defensins have been isolated from avian heterophils. In addition, beta-defensins were found to be constitutively or inducibly expressed at mucosal surfaces of the respiratory, intestinal and urogenital tracts. In this review the current knowledge of the defensin repertoire of birds, their tissue-specific expression, regulation and corresponding biological functions are described.

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Section: Urogenital Tractmentioning

confidence: 99%

Avian defensins

Dijk

Veldhuizen

Haagsman

2008

Veterinary Immunology and Immunopathology

181

149

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“…Another study showed the presence of transcripts of LAP, TAP, in bovine uterus -in endometrial epithelial cells treated with E. coli LPS, as well as the LAP and TAP transcripts in uterine stromal cells (Davies et al, 2008). Aono et al (2006) compared the gene structure and amino-acid sequence of bovine beta-defensin 1 (BBD-1) with its human counterpart (hBD-1) and with other bovine beta-defensins. They showed that bovine BD-1 gene has one long intron, as large as the intron of the human gene (8547 bp in hBD-1 vs. 6962 in BBD-1), about five-fold longer then introns of other known bovine beta-defensin genes.…”

Section: Defensins In Cattlementioning

confidence: 99%

Expression and polymorphism of defensins in farm animals.

et al. 2010

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Due to their activity against bacteria, viruses, and fungi, antimicrobial peptides are important factors in the innate resistance system of humans and animals. They are called "new generation antibiotics" for their potential use in preventive and therapeutic medicine. The most numerous group of antimicrobial peptides is a family of cationic peptides which include defensins and cathelicidins. Among them the most common are peptides with a beta-sheet structure containing three intra-molecular disulphide bonds, called defensins, comprising three classes: alpha, beta, and theta. The class of beta-defensins is the largest one. Their transcripts have been found in many tissues of humans and animals. The aim of this paper is to present the current knowledge about antimicrobial peptides from the defensin family in farm animals, their expression, polymorphism, as well as the potential of their use as genetic markers of health and production traits.

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“…Βο ινε β-δεφενσιν 1 Aono et al (2006) identified a novel β-defensin that showed more similarity to human β-defensin than to other bovine β-defensins and named it as bovine β-defensin 1gene (bBD1). It containstwo exons and one large intron, which resulted in 69 amino acids propeptide.…”

Section: εντερις β-δεφενσινςmentioning

confidence: 99%

Antimicrobial Peptides in Farm animals: An updated review on its diversity, function, mode of action and therapeutic prospects

Kumar¹,

Ali²,

Singh³

et al. 2020

Preprint

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Antimicrobial peptides (AMPs) are the arsenals of the innate host defense system exhibiting the ancient evolutionarily conserved characteristics that is present in practically all forms of life. Recent years have witnessed emergence of antibiotic resistant bacteria compounded with a slow discovery rate for new antibiotics that has necessitated scientific efforts to search for alternatives to antibiotics. Research on the identification of AMPs has generated very encouraging evidences that they curb infectious pathologies and are also useful as novel biologics to function as immunotherapeutic agents. Being innate, they exhibit least toxicity to the host and exert wide spectrum of biological activity including low resistance among microbes, and increased wound healing actions. Notably, in veterinary science, the constant practice of massive doses of antibiotics with inappropriate withdrawal programs led to the high risk of livestock-associated antimicrobial resistance. Therefore, the world faces tremendous pressure for designing and devising strategies to mitigate the use of antibiotics in animals and keep it safe for the posterity. In this review, we illustrate the diversity of farm animals specific AMPs, their biochemical foundations, mode of action and prospective application in clinics. Subsequently, we present the data for their systematic classification by the major and minor groups, antipathogenic action, and allied bioactivities in the host. Finally, we address the limitations to their clinical implementation and envision areas for further advancement.

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Molecular and functional characterization of bovine β-defensin-1

Cited by 24 publications

References 30 publications

Avian defensins

Avian defensins

Expression and polymorphism of defensins in farm animals.

Antimicrobial Peptides in Farm animals: An updated review on its diversity, function, mode of action and therapeutic prospects

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