Molecular and cellular biology of alveolar bone

Sodek, Jaro; McKee, Marc D.

doi:10.1034/j.1600-0757.2000.2240106.x

Cited by 219 publications

(217 citation statements)

References 247 publications

Supporting

Mentioning

169

Contrasting

Unclassified

Order By: Relevance

“…This dynamic mechanism can be affected according to the concentration of PGE 2 . [6][7][8][9][10] Saito et al 9 showed that periodontal ligament cells respond to mechanical stress (in vivo and in vitro) by an increased production of PGE 2 . Thus, after the application of mechanical forces, cells in the periodontal ligament produce sufficient amounts of mediators to diffuse into the gingival crevicular fluid.…”

Section: Introductionmentioning

confidence: 99%

Juveniles versus adults: differences in PGE2 levels in the gingival crevicular fluid during orthodontic tooth movement

2010

View full text Add to dashboard Cite

Juveniles versus adults: differences in PGE 2 levels in the gingival crevicular fluid during orthodontic tooth movement Abstract: This study aimed to investigate age-related changes in the biosynthetic capacity of prostaglandin E 2 (PGE 2 ) in the gingival crevicular fluid (GCF) during one month of orthodontic treatment. Twentyfive juvenile subjects (mean age 13 ± 2.1 years) and 23 adults (mean age 24 ± 2.1 years) were included. GCF was collected immediately before the force application at the baseline, 2, 21 and 28 days, with periopaper inserted into the gingival crevice of the maxillary lateral incisors. The mediator levels were determined with an EIA kit. The results showed that the PGE 2 concentrations were significantly elevated from the baseline to 21 days (129.35 and 198.84 pg/µL, p = 0.0169) in juvenile subjects and reduced from 21 to 28 days (198.84 to 112.60 pg/µL, p = 0.0032). Adults, however, had no significant changes in the PGE 2 levels. The total amounts of PGE 2 from both groups changed between the baseline to 21 and 21 to 28 days (p = 0.0119 and p = 0.0076, respectively). The PGE 2 initial and final levels showed significant differences between the juveniles and adults, being higher in adults (baseline: juvenile = 129.35 pg/µL vs. adult = 163.20 pg/µL, p = 0.0379; t3: juvenile = 112.60 pg/µL and adult = 175.30 pg/µL, p = 0.0005). In conclusion, the results demonstrate the presence of variation in the PGE 2 levels according to age and the orthodontic activation period, which can explain why the speed of orthodontics treatment may be different in adults vs. juveniles.

show abstract

Section: Introductionmentioning

confidence: 99%

Juveniles versus adults: differences in PGE2 levels in the gingival crevicular fluid during orthodontic tooth movement

2010

View full text Add to dashboard Cite

show abstract

“…A formação desse tecido envolve a proliferação e a diferenciação de células do estroma ao longo de uma via osteogênica de múltiplas etapas. Esse processo de diferenciação celular é controlado por uma cascata de eventos que abrange uma programação genética associada à regulação gênica por vários hormônios, citocinas e fatores de crescimento (24) . O osso é formado por dois métodos de diferenciação do mesênquima (12,21) : ossificação intramembranosa (15,25) e ossificação endocondral (18,26) .…”

Section: Introductionunclassified

Influência da vitamina D na atividade osteoclástica em um modelo de cultura de órgãos ósseos

Ginani¹,

Barboza²

2011

J. Bras. Patol. Med. Lab.

View full text Add to dashboard Cite

Introdução: A remodelação óssea é regulada por várias citocinas e hormônios, como a vitamina D3. Essa vitamina, em particular, regula positiva e negativamente a expressão do ligante do receptor ativador do fator nuclear kappa-B (RANKL) e da osteoprotegerina (OPG), respectivamente, e é usada como um indutor da formação de osteoclastos in vitro. Objetivo: Estudar o efeito da vitamina D (VitD) sobre a atividade osteoclástica em cultura de calvárias. Material e método: Fragmentos de calvária de camundongos foram cultivados com meio básico (controle) ou com meio contendo VitD (10 nM: baixa dose; 100 nM: alta dose). Após os intervalos de 24, 48 e 72 horas, o meio de cultura foi coletado para dosagem de cálcio e os fragmentos foram fixados para análise em microscopia confocal. Resultados: Observou-se que a adição de VitD nas duas dosagens promoveu aumento nos níveis de cálcio no meio, porém só foram encontradas diferenças estatisticamente significativas entre alta e baixa dose no intervalo de 24 horas. Na microscopia, foram observadas áreas de desmineralização mais amplas nos fragmentos de calvária cultivados com altas doses de VitD.

show abstract

“…The alveolar bone has high plasticity and under physiological conditions it is preserved by the equilibrium between osteoblastic and osteoclastic activities. These cells are directly or indirectly influenced by the parathyroid hormone (PTH), vitamin D metabolites, calcitonin, estrogen, plasmatic concentration of calcium and phosphate, neurotransmitters, growth factors, and local cytokines 24 . The reduction in bone formation might be due to a decrease in osteoblast-proliferating precursors or to decreased synthesis and secretion of essential bone matrix proteins 6,23 .…”

Section: Wwwintechopencommentioning

confidence: 99%

Effects of Human Ageing on Periodontal Tissues

Hebling¹

2012

Periodontal Diseases - A Clinician's Guide

View full text Add to dashboard Cite

Molecular and cellular biology of alveolar bone

Cited by 219 publications

References 247 publications

Juveniles versus adults: differences in PGE2 levels in the gingival crevicular fluid during orthodontic tooth movement

Juveniles versus adults: differences in PGE2 levels in the gingival crevicular fluid during orthodontic tooth movement

Influência da vitamina D na atividade osteoclástica em um modelo de cultura de órgãos ósseos

Effects of Human Ageing on Periodontal Tissues

Contact Info

Product

Resources

About