Molecular and biochemical evidence on the protective effects of embelin and carnosic acid in isoproterenol-induced acute myocardial injury in rats

Koçak, Cengiz; Koçak, Fatma Emel; Akçılar, Raziye; Işıklar, Özben Özden; Koçak, Havva; Bayat, Zeynep; Şimşek, Hasan; Taşer, Figen; Altuntaş, İrfan

doi:10.1016/j.lfs.2016.01.038

Cited by 63 publications

(38 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Tissue TOS levels were signifi cantly higher in the MI group (group 3) than in the control group (group 1 and 2) on sampling day 28. This fi nding is consistent with the fi ndings of Kocak et al (2016) who examined the protective effects of embelin and carnosic acid on isoproterenol-induced heart damage in rats (28).…”

Section: Discussionsupporting

confidence: 90%

Periostin normalizes levels of cardiac markers in rats with experimental isoproterenol cardiotoxicity

Devrim¹,

Sözmen²,

Devrim³

et al. 2017

BLL

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 90%

Periostin normalizes levels of cardiac markers in rats with experimental isoproterenol cardiotoxicity

Devrim¹,

Sözmen²,

Devrim³

et al. 2017

BLL

View full text Add to dashboard Cite

show abstract

“…Moreover, hydroxytyrosol maintains cardiomyocyte viability through inhibiting intracellular ROS generation and mediating the phosphorylation of survival or death related proteins in H9c2 cells subjected to xanthine/xanthine oxidase-induced oxidative stress [ 27 ] . In vivo , when the rats were treated with isoproterenol, MI was obviously induced as ejection fraction, fractional shortening, disarranged cardiac muscle fibers and inflammatory cell infiltration decreased, which is consistent with the finding of previous studies [ 28 – 29 ] .…”

Section: Discussionsupporting

confidence: 91%

Hydroxytyrosol and olive leaf extract exert cardioprotective effects by inhibiting GRP78 and CHOP expression

Yang

et al. 2018

J Biomed Res

View full text Add to dashboard Cite

Myocardial infarction triggers massive biochemical changes, even cardiac cell death. Endoplasmic reticulum stress is involved in the pathology of myocardial infarction-mediated apoptosis. In the present study, myocardial cell line H9c2 cells were treated with cobalt chloride (CoCl2) to induce hypoxia. Isoproterenol was used for two successive days to induce myocardial infarction in SD rats. The cardioprotective effect of olive leaf extract (OLE) and its main constituent hydroxytyrosol and the underlying mechanisms were evaluated. The results showed that hydroxytyrosol markedly protected H9c2 cells against CoCl2-induced apoptosis. Hydroxytyrosol could reduce the mRNA and protein expression of GRP78 and CHOP induced by CoCl2 in vitro. In vivo, the decreased ejection fraction and fractional shortening, increased heart weight/body ratio, the formation of infarction, disordered cardiac muscle fibers and infiltration of inflammatory cells induced by isoproterenol could be significantly ameliorated by pretreatment with OLE for a month. Similarly, OLE could also reverse the increase of GRP78 and CHOP expression induced by isoproterenol. Therefore, OLE and hydroxytyrosol exert a cardioprotective effect through endoplasmic reticulum stress, which could be a new target for the prevention and treatment of cardiovascular diseases.

show abstract

“…Moreover, embelin pretreatment considerably decreased the pathological changes such as loss of myofibrillar alignment, myocardial degeneration, severe cytoplasmic vacuolization, and infiltration of inflammatory cells when compared with only ISP administered rats (Sahu et al, ). Kocak et al () reported similar cardioprotective effects of embelin and carnosic acid via modulation of NFκB‐Nrf‐2‐MAPK pathway. Thus, the use of amla‐based formulations in Ayurveda can be rationalized with these findings.…”

Section: Natural Products and Their Pharmacological Potential In Allementioning

confidence: 88%

Isoproterenol‐induced cardiac ischemia and fibrosis: Plant‐based approaches for intervention

Allawadhi

Khurana

Sayed

et al. 2018

Phytotherapy Research

View full text Add to dashboard Cite

Heart is the most active and incumbent organ of the body, which maintains blood flow, but due to various pathological reasons, several acute and chronic cardiac complications arise out of which myocardial infarction is one of the teething problems. Isoproterenol (ISP)-induced myocardial ischemia is a classical model to screen the cardioprotective effects of various pharmacological interventions. Phytochemicals present a novel option for treating various human maladies including those of the heart. A large number of plant products and their active ingredients have been screened for efficacy in ameliorating ISP-induced myocardial ischemia including coriander, curcumin, Momordica, quercetin, and Withania somnifera. These phytochemicals constituents may play key role in preventing disease and help in cardiac remodeling. Reactive oxygen species scavenging, antiinflammatory, and modulation of various molecular pathways such as Nrf2, NFкB, p-21 activated kinase 1 (PAK1), and p-smad2/3 signaling modulation have been implicated behind the claimed protection. In this review, we have provided a focused overview on the utility of ISP-induced cardiotoxicity, myocardial ischemia, and cardiac fibrosis for preclinical research. In addition, we have also surveyed molecular mechanism of various plant-based interventions screened for cardioprotective effect in ISP-induced cardiotoxicity, and their probable mechanistic profile is summarized.

show abstract

Molecular and biochemical evidence on the protective effects of embelin and carnosic acid in isoproterenol-induced acute myocardial injury in rats

Cited by 63 publications

References 46 publications

Periostin normalizes levels of cardiac markers in rats with experimental isoproterenol cardiotoxicity

Periostin normalizes levels of cardiac markers in rats with experimental isoproterenol cardiotoxicity

Hydroxytyrosol and olive leaf extract exert cardioprotective effects by inhibiting GRP78 and CHOP expression

Isoproterenol‐induced cardiac ischemia and fibrosis: Plant‐based approaches for intervention

Contact Info

Product

Resources

About