Molecular Analysis of the Progression from<i>Helicobacter pylori</i>–Associated Chronic Gastritis to Mucosa-Associated Lymphoid-Tissue Lymphoma of the Stomach

Zucca, Emanuele; Bertoni, Francesco; Ricevuto, Enrico; Bosshard, Giovanna; Cazzaniga, Giovanni; Pedrinis, E; Biondi, Andrea; Cavalli, Franco

doi:10.1056/nejm199803193381205

Cited by 225 publications

(123 citation statements)

References 33 publications

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“…Monoclonality is established either by light chain restriction or by assessment of immunoglobulin heavy chain gene rearrangements by the polymerase chain reaction (PCR). However, monoclonality also can be detected in uncomplicated chronic gastritis and has been shown to precede the histological evidence of malignant transformation [48,49]. Therefore, gastric MALT lymphoma should not be diagnosed in the absence of supportive histological evidence.…”

Section: Diagnosismentioning

confidence: 99%

Non-Hodgkin's Lymphoma of Mucosa-Associated Lymphoid Tissue

et al. 2006

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Section: Diagnosismentioning

confidence: 99%

Non-Hodgkin's Lymphoma of Mucosa-Associated Lymphoid Tissue

et al. 2006

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“…Today, it is considered to be a pathogen important to the development of gastrointestinal ulcers and it has been implicated as a carcinogen for gastric cancer and mucosa-associated lymphoid-tissue lymphoma of the stomach (2,3). H. pylori has been detected in dental plaque, saliva, and the subgingival region (4)(5)(6)(7)(8), and there have been reports that H. pylori strains in the mouth and stomach are identical (7,9,10).…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori in oral ulcerations.

Shimoyama

Horie

Kato

et al. 2000

Journal of Oral Science

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Abstract:Helicobacter pylori is an important pathogen involved in the development of gastrointestinal ulcers, but its involvement in oral ulcerous lesions is unclear. As culture is generally recognized as the gold standard for diagnosis of H. pylori infection, we employed this approach to assess the association of H.pylori with oral mucosal ulcerations. Samples were collected from patients with oral mucosal ulcerative disorders: 12 cases of recurrent aphthous stomatitis (RAS), 7 cases of herpes simplex virus (HSV) stomatitis, and 3 cases of erosive lichen planus (LP). Serum IgG antibodies against H. pylori were examined in all cases. All of the RAS and erosive LP cases were culturenegative for H. pylori, while two cases of HSV stomatitis were positive. The two culture-positive cases were also seropositve for the H. pylori antigen. It is suggested that H. pylori might not have a direct association with oral ulcerations. However, H. pylori in the oral cavity might exist in a non-culturable coccoid state without productive infection, and might form colonies only under special conditions such as HSV infection. (J. Oral Sci. 42, 225-229 , 2000)

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“…It is also associated with the development of MALT lymphoma (Wotherspoon et al 1993, Zucca et al 1998) and carcinoma of the stomach (Uemura et al 2001, Passaro et al 2002.…”

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confidence: 99%