1994
DOI: 10.1006/viro.1994.1137
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Molecular Analysis of the Glycoprotein C-Negative Phenotype of Attenuated Marek's Disease Virus

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Cited by 16 publications
(13 citation statements)
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“…One explanation of this effect is that soluble gC in cell culture can bind to an unknown receptor on the surfaces of neighboring cells, which may block interaction of membrane-bound gC that could play a role for cell-to-cell spread of MDV. This interpretation is supported by the fact that gC expression is reduced after only a few passages in vitro of highly virulent MDV strains (73). Irrespective of the mode of action of the secreted form of gC, our findings indicate a strong pressure for gC down regulation in cell culture, although some attenuated and passaged strains, such as CVI988-Rispens, still express significant amounts of gC and yet produce relatively large plaques in cultured cells (B. K. Tischer and N. Osterrieder, unpublished observations).…”
Section: Discussionmentioning
confidence: 84%
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“…One explanation of this effect is that soluble gC in cell culture can bind to an unknown receptor on the surfaces of neighboring cells, which may block interaction of membrane-bound gC that could play a role for cell-to-cell spread of MDV. This interpretation is supported by the fact that gC expression is reduced after only a few passages in vitro of highly virulent MDV strains (73). Irrespective of the mode of action of the secreted form of gC, our findings indicate a strong pressure for gC down regulation in cell culture, although some attenuated and passaged strains, such as CVI988-Rispens, still express significant amounts of gC and yet produce relatively large plaques in cultured cells (B. K. Tischer and N. Osterrieder, unpublished observations).…”
Section: Discussionmentioning
confidence: 84%
“…We have demonstrated that gC expression is clearly detrimental to virus growth in vitro. Further experiments will focus on the function of gC in chickens to elucidate whether there is a correlation of the level of gC expression and MDV pathogenesis as discussed by other groups (31,73) or whether the reduction of the U L 44 expression in vitro is more a cell culture effect that is independent of virulence. In addition, future studies will aim at dissecting the effects of the soluble form versus the membrane-bound form of the glycoprotein by the introduction of targeted mutations in a predicted common splice acceptor site that would abrogate expression of two secreted gC products that result from two putative spliced mRNAs.…”
Section: Discussionmentioning
confidence: 98%
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