1996
DOI: 10.1128/jb.178.23.6790-6795.1996
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Molecular analysis of the gat genes from Escherichia coli and of their roles in galactitol transport and metabolism

Abstract: In enteric bacteria, the hexitol galactitol (Gat) (formerly dulcitol) is taken up through enzyme II (II Gat ) of the phosphoenolpyruvate-dependent phosphotransferase system (PTS), and accumulated as galactitol 1-phosphate (Gat1P). The gat genes involved in galactitol metabolism have been isolated from the wild-type isolate Escherichia coli EC3132 and cloned on a 7.8-kbp PstI DNA fragment. They comprise six complete open reading frames and one truncated open reading frame in the order gatYZABCDR. The genes gatA… Show more

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Cited by 91 publications
(81 citation statements)
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“…This reaction makes nitrogen available for pyrimidine nucleotide and arginine biosynthesis. The gatYZ gene products convert galactitol to glyceraldehyde 3-phosphate (30). It seems that FlhD and FlhD/FlhC play a role in balancing amino acid degradation and biosynthesis pathways.…”
Section: Discussionmentioning
confidence: 99%
“…This reaction makes nitrogen available for pyrimidine nucleotide and arginine biosynthesis. The gatYZ gene products convert galactitol to glyceraldehyde 3-phosphate (30). It seems that FlhD and FlhD/FlhC play a role in balancing amino acid degradation and biosynthesis pathways.…”
Section: Discussionmentioning
confidence: 99%
“…1) under the control of the gat promoter on a plasmid, which contains a CRP activation region and a gat repressor binding site. Because wild-type K12 E. coli strains lack a functional gat repressor protein, GatR (27), RFP is a faithful reporter for the activity of CRP (28).…”
Section: The Lactose Uptake Networkmentioning
confidence: 99%
“…All bacterial species use pathways to reduce NAD + to NADH, for example respiration, which involves either glycolysis and the tricarboxylic acid cycle or fermentation (Jurtshuk, 1996). Bacteria also use NAD + in several forms of dehydrogenases when breaking down aldehydes and alcohols (Kotrbova-Kozak et al, 2007;Luong et al, 2015;Nobelmann & Lengeler, 1996;Temple et al, 1994). NAD is utilized in a number of cellular processes in both bacterial and mammalian cells, for example DNA ligation and repair, redox recycling in the pyruvate dehydrogenase pathway, and synthesis of acetyl-CoA for the tricarboxylic acid cycle (Chalkiadaki & Guarente, 2012;Chiarugi et al, 2012;Ishino et al, 1986;Patel et al, 2014;Satoh & Lindahl, 1992;Wilkinson et al, 2001).…”
Section: Introductionmentioning
confidence: 99%