Molecular analysis of oral bacteria in dental biofilm and atherosclerotic plaques of patients with vascular disease

Abstract

SM was found at a high frequency in oral and vascular samples, even in edentulous patients, and its presence in atherosclerotic plaques suggests the possible involvement of this bacterium in the disease progression.

Emerging Evidence for Pathogenesis of Sporadic Cerebral Small Vessel Disease

“…This corresponds with findings showing periodontal infections to be risk factors for stroke, 47,48 and that S. mutans is detected in 100% of samples of atherosclerotic plaques. 49 S. mutans is a major pathogen in dental caries that can cause bacteremia by dental procedures, such as tooth extraction and periodontal surgery, or even tooth brushing in daily life. 50 The hemorrhage-causing S. mutans strains express collagen-binding proteins on their cell surface, enabling them to attach effectively to exposed …”

“…[46] недавно продемонстрировали, что некото-рые штаммы Streptococcus mutans являются потенциаль-ными факторами риска развития внутримозгового кро-воизлияние у КСГПИ и мышей с фотохимически инду-цированной окклюзией средней мозговой артерии. Это соответствует результатам, показывающим, что инфек-ции пародонта являются факторами риска развития инсульта [47,48] и что S. mutans обнаруживается в 100% образцов атеросклеротических бляшек [49]. S. mutans является одним из основных патогенов кариеса зубов и может быть причиной появления бактериемии при стоматологических процедурах, таких как удаление зуба и хирургическое вмешательство на тканях пародонта, или даже при чистке зубов в повседневной жизни [50].…”

Increasing Evidence for an Association Between Periodontitis and Cardiovascular Disease

“…A diverse range of oral bacterial pathogens and bacterial DNA have been detected in atherosclerotic plaque. 15,16 In animal models, infection with Porphyromonas gingivalis increases atherosclerotic plaque volume with the accumulation of cholesterol esters and inflammatory mediators. 17 In humans, serum IgA antibodies to P gingivalis are higher in patients with myocardial infarction than in controls.…”

Interaction between periodontal disease and atherosclerotic vascular disease – Fact or fiction?

“…These and other studies suggest that a multitude of bacterial species may contribute to the pathogenesis of atherosclerosis [55e57]. It is interesting to note that the detection of bacteria associated with the oral cavity is not limited to pathogens associated with severe states of oral diseases, like P. gingivalis, but was also reported for bacteria that are associated generally speaking with increased amounts of dental plaque on tooth surfaces, like streptococci [58].…”