Increasing Evidence for an Association Between Periodontitis and Cardiovascular Disease

Association between periodontal flap surgery for periodontitis and vasculogenic erectile dysfunction in Koreans

“…Sharma et al [21] reported that chronic PD was present in 81.8% of male patients with severe ED. Their data are supported by the strong association between PD and VED, which share the same inflammatory reaction mechanism [22]. There is evidence of inflammatory mediators such as interleukin (IL)-6, IL-8, IL-18, and TNF-α being associated with endothelial dysfunction [22].…”

“…Their data are supported by the strong association between PD and VED, which share the same inflammatory reaction mechanism [22]. There is evidence of inflammatory mediators such as interleukin (IL)-6, IL-8, IL-18, and TNF-α being associated with endothelial dysfunction [22]. In addition, treatment of chronic PD has been prospectively validated to reduce the risk of endothelial dysfunction at 6 months following therapy [23].…”

“…Despite these limitations, this well-controlled longitudinal cohort study that included smoking status found that PSTP was closely related to VED, as PD is known to be a risk or modifying factor for cardiovascular disease and diabetes mellitus [22]. Since PSTP have worse periodontal status than general patients with PD, the necessity of surgery seems to be more strongly associated with VED, and these patients are more likely to suffer from VED.…”

Letter by Dizman et al Regarding Article, “Periodontitis Increases the Risk of a First Myocardial Infarction: A Report From the PAROKRANK Study”

“…2 The PAROKRANK study (Periodontitis and Its Relation to Coronary Artery Disease), as a case-control study, would not be able to clarify the causal relationship between periodontitis and first myocardial infarction. In the article and the related editorial, 3 this point is broadly explained by the authors in addition to the potential difficulties of designing a prospective trial to clarify a causality between 2 entities. However, use of the word "increases" might lead to a misconception among readers that this study demonstrates causality.…”

Comparison of periodontal parameters among cardiovascular patients and healthy controls

“…* Although, several studies in other countries have claimed relationship between CVD and periodontal diseases (13)(14)(15)(16), American Heart Association (AHA) claims that periodontal disease is associated with atherosclerosis but further concludes that there is no evidence for such relation, possibly due to several research gaps (17). Other comprehensive researches show an association between periodontitis and CVD, but they also say more research should be conducted to make better evidences (18,19), and also not enough studies have succeeded to show that CVD may increase the risk of periodontal complications (20). Effects of smoking, high blood pressure and high amount of blood lipids on CVD have been proved.…”