Molar incisor hypomineralization: Prevalence and severity in schoolchildren of Puno, Peru

Quispe, Denise Milagros Argote; Priego, Guido Perona Miguel de; Manco, Roberto Antonio León; Portaro, Camila Palma

doi:10.4103/jisppd.jisppd_460_20

Cited by 3 publications

(10 citation statements)

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“…The results of a recent meta-analysis by Mazur et al revealed a significant correlation between MIH and caries in permanent dentition in children [17]. However, a few researchers have not confirmed this [18,19]. Additionally, in our study, there were no significant differences in caries prevalence between the MIH and non-MIH groups; therefore, no adjustment for caries was performed.…”

Section: Discussioncontrasting

confidence: 69%

Association of Three Genetic Loci with Molar Incisor Hypomineralization in Polish Children

Milona,

Ciechanowicz,

Węsierska

et al. 2024

JCM

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Background: Molar incisor hypomineralization (MIH) is a qualitative, demarcated enamel defect of hypomineralization affecting one to four first permanent molars, often with incisor involvement. Its etiology is complex. However, evidence suggests the influence of genetic factors, potentially including the single nucleotide polymorphisms (SNPs) rs2889956, rs4811117 and rs13058467, which were previously linked to MIH in a genome-wide association study of German children. The aim was to replicate analyses of possible associations between the SNPs and molar incisor hypomineralization in Polish children. Methods: The final study group consisted of 778 children aged 126–168 months old. Saliva samples were taken, and genomic DNA was extracted and genotyped using beadchip microarrays. Results: Among the 778 subjects, there were 68 (8.7%) subjects with MIH and 710 (91.3%) subjects without MIH. There were no significant differences in distributions in age, sex, or the frequency of caries in permanent dentition between the MIH and non-MIH groups. The rs2889956, rs4811117, and rs13058467 genotype distributions in the studied group conformed to the expected Hardy–Weinberg equilibria, and there were no significant differences in the distributions of their alleles or genotypes between the MIH and non-MIH groups. Conclusion: Our replication study did not confirm highly significant associations between the single nucleotide polymorphisms rs2889956, rs4811117, and rs13058467 with molar incisor hypomineralization in Polish children.

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Section: Discussioncontrasting

confidence: 69%

Association of Three Genetic Loci with Molar Incisor Hypomineralization in Polish Children

Milona,

Ciechanowicz,

Węsierska

et al. 2024

JCM

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“…According to the Newcastle-Ottawa scale (NOS) for cross-sectional studies (n: 59) [ 12 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , …”

Section: Resultsunclassified

“…18 studies reported data on the Decayed, Missing, and Filled Teeth (DMFT) index [ 12 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ] and 12 for dmft [ 12 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 40 , 41 , 43 , 44 ], with data sufficient for meta-analysis to assess differences in caries experience among patients with and without MIH.…”

Section: Resultsmentioning

confidence: 99%

“…In the present study, two studies (11%) [ 31 , 38 ] were of enrolled children in a dental clinic or general hospital setting, and 16 studies (89%) [ 12 , 25 , 26 , 27 , 29 , 30 , 31 , 32 , 33 , 34 , 36 , 37 , 38 , 39 , 40 , 41 ] were in a population-based setting such as schools. Six studies were conducted in Europe [ 12 , 28 , 31 , 34 , 38 , 42 ], five studies in Asia [ 30 , 33 , 35 , 41 , 43 ], one study both in Europe and Asia [ 36 ], one study in Oceania [ 29 ], four studies in South America [ 31 , 37 , 39 , 44 ], and one study in North America [ 40 ]. The presence or absence and gravity of MIH were evaluated in 14 cases (78%) [ 12 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 43 , ...…”

Section: Discussionmentioning

confidence: 99%

“… Forest plot for DMFT. A positive value of the mean difference means a higher DMFT level in the MIH group [ 12 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. …”

Section: Figurementioning

confidence: 99%

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MIH and Dental Caries in Children: A Systematic Review and Meta-Analysis

et al. 2023

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(1) Background: Molar-incisor hypomineralization (MIH) is a clinical condition affecting permanent teeth in children, with a documented rising trend in the last two decades. The aim of the present study was to analyze and synthesize the available evidence on caries experience (dmft/DMFT) and MIH in children. (2) Methods: A systematic review and meta-analysis were conducted according to the PRISMA statement. (3) Results: 59 papers published between 2007 and 2022 were included in the qualitative synthesis and 18 in the meta-analysis. The total sample of subjects was 17,717 (mean: 896), of which 2378 (13.4%) had MIH (mean: 119), with a girl/boy ratio of 1:1. The mean age of the enrolled participants was 8.6 (age range 7–10 years). Meta-analysis showed that MIH has a positive correlation with both dmft (effect size of 0.67, 95% CI [0.15, 1.19]) and DMFT (effect size of 0.56, 95% CI [0.41, 0.72]); (4) Conclusions: Children with MIH should be diagnosed correctly and on time. Treatment and management options for moderate and severe forms of MIH should consider prognosis based on known risk factors, and secondary and tertiary prevention policies should also consider the multifactorial nature of caries etiology.

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Which are the clinical consequences of Molar Incisor hypomineralization (MIH) in children and adolescents? Systematic review and meta-analysis

Gevert,

Wambier,

Ito

et al. 2024

Clin Oral Invest

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Molar incisor hypomineralization: Prevalence and severity in schoolchildren of Puno, Peru

Cited by 3 publications

References 0 publications

Association of Three Genetic Loci with Molar Incisor Hypomineralization in Polish Children

Association of Three Genetic Loci with Molar Incisor Hypomineralization in Polish Children

MIH and Dental Caries in Children: A Systematic Review and Meta-Analysis

Which are the clinical consequences of Molar Incisor hypomineralization (MIH) in children and adolescents? Systematic review and meta-analysis

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