MIH and Dental Caries in Children: A Systematic Review and Meta-Analysis

Mazur, Marta; Corridore, Denise; Ndokaj, Artnora; Ardan, Roman; Vozza, Iole; Babajko, Sylvie; Jedeon, Katia

doi:10.3390/healthcare11121795

Cited by 9 publications

(5 citation statements)

References 93 publications

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“…Similar to Kühnisch et al [12], in our analyses we did not apply adjustments for sex and age because there were no statistically significant differences in these variables between the MIH and non-MIH groups. The results of a recent meta-analysis by Mazur et al revealed a significant correlation between MIH and caries in permanent dentition in children [17]. However, a few researchers have not confirmed this [18,19].…”

Section: Discussionmentioning

confidence: 97%

Association of Three Genetic Loci with Molar Incisor Hypomineralization in Polish Children

Milona,

Ciechanowicz,

Węsierska

et al. 2024

JCM

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Background: Molar incisor hypomineralization (MIH) is a qualitative, demarcated enamel defect of hypomineralization affecting one to four first permanent molars, often with incisor involvement. Its etiology is complex. However, evidence suggests the influence of genetic factors, potentially including the single nucleotide polymorphisms (SNPs) rs2889956, rs4811117 and rs13058467, which were previously linked to MIH in a genome-wide association study of German children. The aim was to replicate analyses of possible associations between the SNPs and molar incisor hypomineralization in Polish children. Methods: The final study group consisted of 778 children aged 126–168 months old. Saliva samples were taken, and genomic DNA was extracted and genotyped using beadchip microarrays. Results: Among the 778 subjects, there were 68 (8.7%) subjects with MIH and 710 (91.3%) subjects without MIH. There were no significant differences in distributions in age, sex, or the frequency of caries in permanent dentition between the MIH and non-MIH groups. The rs2889956, rs4811117, and rs13058467 genotype distributions in the studied group conformed to the expected Hardy–Weinberg equilibria, and there were no significant differences in the distributions of their alleles or genotypes between the MIH and non-MIH groups. Conclusion: Our replication study did not confirm highly significant associations between the single nucleotide polymorphisms rs2889956, rs4811117, and rs13058467 with molar incisor hypomineralization in Polish children.

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Section: Discussionmentioning

confidence: 97%

Association of Three Genetic Loci with Molar Incisor Hypomineralization in Polish Children

Milona,

Ciechanowicz,

Węsierska

et al. 2024

JCM

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“…The inferior physical properties of MIH-affected enamel have been readily translated to the assumption that MIH-affected dentitions have a higher caries risk than non-affected individuals, but this is not reflected in the literature, where there is an incongruity reported in the relationship between MIH and caries. A recent systematic review evaluated 59 papers between 2007 and 2022 and reported a significant association between MIH and caries lesions diagnosed via the WHO index (mean difference in DMFT 0.56 [0.41, 0.72]) [31]. The clinical significance of this mean difference in DMFT is difficult to interpret, but as it is below 1, it could be argued to be nominal.…”

Section: Dental Cariesmentioning

confidence: 99%

The Impact of Molar Incisor Hypomineralisation on Children and Adolescents: A Narrative Review

Shields,

Chen,

Crombie

et al. 2024

Healthcare

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Molar incisor hypomineralisation (MIH) is a qualitative developmental enamel defect with a prevalence of 13% worldwide. This review aims to outline the current evidence regarding the impact of MIH on children’s oral health and, more broadly, their day-to-day activities. MIH is associated with negative sequelae, including hypersensitivity, post-eruptive breakdown, the rapid development of carious lesions and poor aesthetics. Other concerns pertain to the clinical management of MIH and include difficulty in achieving local anaesthesia, increased dental fear and anxiety (DFA) and increased behaviour management problems. Oral health-related quality of life (OHRQoL) is the most standardised measure of patient impact; however, no instruments have been validated for use in MIH populations. The few existing observational studies investigating the impact of MIH on OHRQoL in children have produced conflicting results. Interventions to alleviate hypersensitivity and improve aesthetics had a positive impact on the OHRQoL of MIH-affected children. Multiple methodological issues make it difficult to measure the impact of MIH, including heterogeneity in the MIH severity classification, an overlap in the indices used to diagnose dental caries and MIH as well as the subjectivity of outcome measures for hypersensitivity and DFA.

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“…Depending on the severity, teeth with MIH may exhibit rapid wear, enamel loss after enamel breakdown and eruption under functional masticatory forces, increased sensitivity to caries, loss of fillings and, above all, severe sensitivity that often causes serious discomfort [ 6 – 11 ]. In addition, MIH causes a higher risk of caries in children, both in the permanent and primary dentition [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Knowledge and Attitudes of a Group of Dental Students in Turkey About Molar Incisor Hypomineralization

Gunay

2023

Med Sci Monit

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Background This study aimed to evaluate the knowledge and attitudes of 4 th - and 5 th -year students of Dicle University Faculty of Dentistry (Diyarbakır) about molar incisor hypomineralization (MIH). Material/Methods The questionnaires previously used in other countries were modified and the questionnaire forms consisting of 23 questions were distributed to the students online. The results of the analysis are presented as frequencies. The significance level was set as P <0.05. Results A total of 111 4 th -year students (51%) and 107 5 th -year students (49%) participated in our study. A statistically significant difference was found between the 4 th -year students (68.5%) and the 5 th -year students (98.1%) in terms of having heard of the term MIH before ( P <0.001). While most students reported knowing the clinical features of MIH, only 26.1% were confident in their diagnosis. A statistically significant difference was found between the 4 th - and 5 th -year students who thought that MIH was a clinical problem, in the distribution of those who had problems both in terms of aesthetics, and in providing adequate restoration ( P =0.012). Conclusions Although most of the students were theoretically familiar with MIH, they were not confident in their diagnosis and found it difficult to differentiate MIH from other dental anomalies. However, the awareness of 5 th -year dental students was better than that of the 4 th -year students.

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MIH and Dental Caries in Children: A Systematic Review and Meta-Analysis

Cited by 9 publications

References 93 publications

Association of Three Genetic Loci with Molar Incisor Hypomineralization in Polish Children

Association of Three Genetic Loci with Molar Incisor Hypomineralization in Polish Children

The Impact of Molar Incisor Hypomineralisation on Children and Adolescents: A Narrative Review

Knowledge and Attitudes of a Group of Dental Students in Turkey About Molar Incisor Hypomineralization

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