Moisissures et habitat : risques pour la santé et espèces impliquées

Reboux, Gabriel; Bellanger, Anne‐Pauline; Roussel, Sandrine; Grenouillet, Frédéric; Millon, Laurence

doi:10.1016/j.rmr.2009.09.003

Cited by 35 publications

(8 citation statements)

References 75 publications

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“…The effects of allergenic molds on public health are well documented (Bellanger et al 2009 ; Packeu et al 2012 ; Reboux et al 2010 ). Indeed, molds can produce mycotoxins, spores, hyphae, and wall fragments containing (1 → 3)-β-D-glucans and proteins which could induce allergic reactions of types I, III, and IV (Douwes et al 2003 ; Seo et al 2008 ).…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, molds can produce mycotoxins, spores, hyphae, and wall fragments containing (1 → 3)-β-D-glucans and proteins which could induce allergic reactions of types I, III, and IV (Douwes et al 2003 ; Seo et al 2008 ). Some studies revealed an association between the fungal levels in the air and the occurrence of allergy (Horner et al 1995 ; Meheust et al 2014 ; Mendell et al 2011 ; Reboux et al 2010 ) and between water-damaged buildings and human exposure to fungal contamination present in indoor air (Jones et al 2011 ; Vesper et al 2013 ). Presently, with the climate change, the new energy conservation measures, the development of the urbanization, and the considerable amount of time spent inside buildings, people are increasingly exposed and might be more susceptible to developing a respiratory problem caused by a fungal contamination (de Ana et al 2006 ; Mendell et al 2011 ; Sharpe et al 2014 ).…”

Section: Introductionmentioning

confidence: 99%

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Development and performance assessment of a qualitative SYBR® green real-time PCR assay for the detection of Aspergillus versicolor in indoor air

Libert

Chasseur

Bladt³

et al. 2015

Appl Microbiol Biotechnol

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Currently, contamination of indoor environment by fungi and molds is considered as a public health problem. The monitoring of indoor airborne fungal contamination is a common tool to help understanding the link between fungi in houses and respiratory problems. Classical analytical monitoring methods, based on cultivation and microscopic identification, depend on the growth of the fungi. Consequently, they are biased by difficulties to grow some species on certain culture media and under certain conditions or by noncultivable or dead fungi that can consequently not be identified. However, they could have an impact on human health as they might be allergenic. Since molecular methods do not require a culture step, they seem an excellent alternative for the monitoring of indoor fungal contaminations. As a case study, we developed a SYBR® green real-time PCR-based assay for the specific detection and identification of Aspergillus versicolor, which is frequently observed in indoor environment and known to be allergenic. The developed primers amplify a short region of the internal transcribed spacer 1 from the 18S ribosomal DNA complex. Subsequently, the performance of this quantitative polymerase chain reaction (qPCR) method was assessed using specific criteria, including an evaluation of the selectivity, PCR efficiency, dynamic range, and repeatability. The limit of detection was determined to be 1 or 2 copies of genomic DNA of A. versicolor. In order to demonstrate that this SYBR® green qPCR assay is a valuable alternative for monitoring indoor fungal contamination with A. versicolor, environmental samples collected in contaminated houses were analyzed and the results were compared to the ones obtained with the traditional methods.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development and performance assessment of a qualitative SYBR® green real-time PCR assay for the detection of Aspergillus versicolor in indoor air

Libert

Chasseur

Bladt³

et al. 2015

Appl Microbiol Biotechnol

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“…Building-related illness (BRI) can be manifested by symptomatology similar to that of SBS, but is medically more serious and is caused by exposure to detected noxae in the room or building [ 12 ]. However, molds have the peculiarity that no dose-response relationship is known, because sensitivity to them varies greatly individually [ 13 ], [ 14 ]. Four main types of BRI are distinguished: allergic and immunological diseases (e.g., hypersensitivity pneumonia, sinusitis, building-related asthma), irritation (e.g., dry eyes, irritant-induced asthma), infections (e.g., Pontiac fever and Legionnaires' disease), and damage from chemicals and other substances (e.g., radon, asbestos) [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Building-related illness (BRI) in all family members caused by mold infestation after dampness damage of the building

Krämer

Wichelhaus

Kempf

et al. 2021

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Introduction: In 2010, dampness damage in a single-family house caused a massive mold infestation. In the further course, the 5 family members developed severe health problems. This report investigates the extent and cause of the water damage. In addition, the various visible fungal infestations were analyzed in a specialized laboratory. Results: Due to building construction errors, starting from the basement, an increased moisture penetration of the residential building was detected. Within 2 years, massive mold infestation occurred. In 2016, the following species were detected: Cladosporium sphaerospermum, Chaetomium globosum, Penicillium chrysogenum, Scopularis brevicaulis, Acremonium furculum, A. charticola and A. sclerotigenum, Trichomonascus apis Aspergillus versicolor and Debaryomyces hansenii . Additionally, different black molds were macroscopically detected. The severity of the disease process varied, probably due to the different daily exposure of the family members, and possibly influenced by age. The children presented acute episodes with nocturnal cough, associated with sleep disturbances and respiratory infections with severe rhinitis. In addition, general fatigue was noticeable. The course of the disease was complicated by recurrent nightly nosebleeds. The mother developed a much more severe course as chronic fatigue syndrome. Additionally, the following continuous complaints occurred: sore throat and headache, nocturnal irritable cough, chronic rhinitis, difficulty concentrating, increasing forgetfulness and word-finding disorders, cognitive impairment with reduced short-term memory, extremely dry eyes with red sclerae, morning stiffness, dyspnea, disturbed temperature regulation (chills), increased feeling of thirst, and menstrual disorders. The father’s building-related illness (BRI) was comparatively mild due to much lower exposure, with nocturnal irritable cough, rhinitis, and marked fatigue. In 2018, after moving out of the house, the father was symptom-free after 2 weeks, the three children after 6 months, but the mother only after 18 months. Discussion: The symptoms are consistent with reports from the literature, according to which fatigue, sleep disturbances, lack of concentration and headache as well as recurrent infections of the upper respiratory tract are caused by microbial volatile organic compounds (MVOCs) released by molds. The association with recurrent nosebleeds in childhood has not been described in this form before. Conclusion: Since in all family members complete remission of symptoms occurred after cessation of the 6-year exposure, there is no doubt that the BRI was caused by the massive mold infestation.

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“…Similarly, improved design and construction of homes can address risk factors to health, including indoor pollution from cooking smoke, which is a major risk factor for acute and chronic respiratory tract diseases [13–18]. Mold can trigger allergic respiratory diseases [19,20], and radon—a radioactive gas derived from rock and soil—is associated with an increased cancer risk [21]. The absence of a hygienic kitchen, safe water supply, and adequate sanitation predisposes inhabitants to enteric diseases.…”

Section: Introductionmentioning

confidence: 99%

Knowledge gaps in the construction of rural healthy homes: A research agenda for improved low-cost housing in hot-humid Africa

Seidlein

Wood²,

Brittain³

et al. 2019

PLoS Med

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Moisissures et habitat : risques pour la santé et espèces impliquées

Cited by 35 publications

References 75 publications

Development and performance assessment of a qualitative SYBR® green real-time PCR assay for the detection of Aspergillus versicolor in indoor air

Development and performance assessment of a qualitative SYBR® green real-time PCR assay for the detection of Aspergillus versicolor in indoor air

Building-related illness (BRI) in all family members caused by mold infestation after dampness damage of the building

Knowledge gaps in the construction of rural healthy homes: A research agenda for improved low-cost housing in hot-humid Africa

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