MOF Nanoparticles with Encapsulated Autophagy Inhibitor in Controlled Drug Delivery System for Antitumor

Chen, Xuerui; Tong, Rongliang; Shi, Zheqi; Yang, Beng; Liu, Hua; Ding, Shiping; Wang, Xu; Lei, Qunfang; Wu, Jian; Fang, Wenjun

doi:10.1021/acsami.7b16522

Cited by 293 publications

(180 citation statements)

References 33 publications

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“…Nanoscale drug delivery system was reported to improve the curative effects of chemotherapeutic drugs by improving its biodistribution and preventing biodegradation in systemic circulation as a result of the enhanced permeability and retention (EPR) effect . In recent years, metal organic framework materials (MOFs) with huge porosity, tunable structure, and ease of modification have been regarded as ideal drug nanocarriers …”

Section: Introductionmentioning

confidence: 99%

A Versatile Prodrug Strategy to In Situ Encapsulate Drugs in MOF Nanocarriers: A Case of Cytarabine‐IR820 Prodrug Encapsulated ZIF‐8 toward Chemo‐Photothermal Therapy

Zhang

Liu

et al. 2018

Adv Funct Materials

199

147

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Zeolitic imidazolate framework-8 (ZIF-8) is an attractive metal organic framework (MOF) in drug delivery. Strong interaction between drugs and ZIF-8 is essential for high drug loadings through in situ construction of MOFs. However, only limited drugs with unique functional groups (COOH, SO 3 H, et al.) can interact with ZIF-8 and be encapsulated satisfactorily so far. Drugs without these functional groups are difficult to be loaded due to the lack of strong interaction. Herein a versatile prodrug strategy is proposed to solve the problems encountered by MOFs. Cytarabine (Ara) is chosen as a model drug since it cannot be loaded in ZIF-8 satisfactorily by itself. New indocyanine green (IR820) is utilized to bond with Ara for the formation of prodrug (Ara-IR820) and endows the prodrug with fluorescence imagingguided chemo-photothermal therapy, in which sulfonic groups strengthen the interaction between prodrug and ZIF-8. This prodrug loaded ZIF-8 is further functionalized with hyaluronic acid (HA) to result in active-targeting HA/ Ara-IR820@ZIF-8 nanoparticles. The in vitro and in vivo results demonstrate its excellent visual cancer therapy with tumor-targeted and pH-responsive release behavior. This design offers a new concept to solve the drug loading problem of MOFs, exhibiting a flexible strategy to expand the biomedical applications of MOFs.

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Section: Introductionmentioning

confidence: 99%

A Versatile Prodrug Strategy to In Situ Encapsulate Drugs in MOF Nanocarriers: A Case of Cytarabine‐IR820 Prodrug Encapsulated ZIF‐8 toward Chemo‐Photothermal Therapy

Zhang

Liu

et al. 2018

Adv Funct Materials

199

147

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“…As arepresentative example,the biocompatible microporous zeolitic imidazolate framework 8( ZIF-8) [3] has been widely proposed for as ustained delivery of aw ide variety of challenging drugs. [4][5][6][7] Although with ap rogressive release, most previous reports refer to that 80-90 %o ft he encapsulated cargo is released within the first % 10 hafter exposure to physiological environments.T hese properties are derived from the chemical instability of ZIF-8 in water, [8] which degrades depending on the ZIF-8 mass-to-water ratio and medium pH, [5,9] thus releasing its cargo.…”

mentioning

confidence: 99%

Aqueous Stable Gold Nanostar/ZIF‐8 Nanocomposites for Light‐Triggered Release of Active Cargo Inside Living Cells

et al. 2019

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Ap lasmonic core-shell gold nanostar/zeoliticimidazolate-framework-8 (ZIF-8) nanocomposite was developed for the thermoplasmonic-driven release of encapsulated active molecules inside living cells.T he nanocomposites were loaded, as aproof of concept, with bisbenzimide molecules as functional cargo and wrapped with an amphiphilic polymer that prevents ZIF-8 degradation and bisbenzimide leaking in aqueous media or inside living cells.T he demonstrated molecule-release mechanism relies on the use of near-IR light coupled to the plasmonic absorption of the core gold nanostars, which creates local temperature gradients and thus,b isbenzimide thermodiffusion. Confocal microscopya nd surfaceenhanced Raman spectroscopy( SERS) were used to demonstrate bisbenzimide loading/leaking and near-IR-triggered cargo release inside cells,t herebyleading to DNAs taining.

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“…Additionally, in NM‐phagy, the level of Beclin1 may be an indicator for antitumor therapy by inhibiting autophagy in cancer cells. In a research paper, Zn 2+ nanomaterials were synthesized by encapsulating 3‐MA in the ZIF‐8 (zeolitic imidazolate framework) to inhibit autophagy of cancer cells, which is shown to have downregulation effect on Beclin1, and is promising for efficient antitumor therapies …”

Section: Nm‐phagy‐related Moleculesmentioning

confidence: 99%

Crosstalk between Autophagy and Nanomaterials: Internalization, Activation, Termination

Wei

Duan

2018

Adv. Biosys.

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NMs, SiO 2 -based NMs, lipid-based NMs, polymer-based NMs, polyethylene glycol (PEG)-based NMs, and other types NMs. Alternatively, according to the physical and chemical properties of NMs, they can be classified into soft NMs, referring to lipidor polymer-based NMs, and hard NMs such as mental-or carbon-based NMs.With the development of nanotechnology, these materials have been widely applied in various fields. [3] For example, ZnO nanoparticles (NPs) can serve as antimicrobial agents; [4] TiO 2 NPs are used in sunscreen lotions; [5] lipid/polymeric-based NPs are applied in drug/gene delivery; [6] QDs are used as florescent probes; [7] and magnetic NPs are applied in magnetic resonance imaging. [8] The NMs not only effectively enhance cellular and subcellular targeting of drugs and the effect of imaging, but also rise the attention on the importance of affirming the effect of NMs on biological systems. It has been recognized that NMs are capable of modulating autophagy. The modulation of NMs on autophagy may be beneficial, since the combinative effect of the NMs' features and autophagy functions is capable of enhancing the accuracy of diagnosis and efficiency of therapies. For example, AgNPs could be a fascinating tool in infections and antimicrobial immunity in that the NM-phagy can modulate the antiviral/antibacterial defenses. [9] In this process, AgNPs lead to the disorganization of mitochondrial network and contribute to the modulation of autophagy (both Rab9-dependent alternative autophagy and Atg-5-dependent classical autophagy) by blocking the autophagic flux. Additionally, AgNPs can reduce the production of CCL-5 and interferon (IFN)-β in influenza-infected cells through the Rab9-dependent alternative autophagy.Autophagy, a "self-digestion" biological process of cellular degradation, is induced when cells are subjected to unfavorable factors, including starvation or drug treatments, accumulation of the damaged organelles, and misfolded proteins. The autophagic process refers to the cargo encompassed into autophagosome and delivery of cargo to lysosomes to degrade and to release macromolecules back into the cytosol. [10] If the "self-digestion" gets out of control, the autophagy dysfunction, including excessive autophagy induction or suppression of autophagy flux, will induce serious diseases, such as cancer, neurodegenerative diseases, immunological diseases, innate turbulence, and even cell death. [11] Therefore, autophagy is Nanomaterials (NMs) are comprehensively applied in biomedicine due to their unique physical and chemical properties. Autophagy, as an evolutionarily conserved cellular quality control process, is closely associated with the effect of NMs on cells. In this review, the recent advances in NM-induced/ inhibited autophagy (NM-phagy) are summarized, with an aim to present a comprehensive description of the mechanisms of NM-phagy from the perspective of internalization, activation, and termination, thereby bridging autophagy and nanomaterials. Several possible mechanisms are extensively ...

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MOF Nanoparticles with Encapsulated Autophagy Inhibitor in Controlled Drug Delivery System for Antitumor

Cited by 293 publications

References 33 publications

A Versatile Prodrug Strategy to In Situ Encapsulate Drugs in MOF Nanocarriers: A Case of Cytarabine‐IR820 Prodrug Encapsulated ZIF‐8 toward Chemo‐Photothermal Therapy

A Versatile Prodrug Strategy to In Situ Encapsulate Drugs in MOF Nanocarriers: A Case of Cytarabine‐IR820 Prodrug Encapsulated ZIF‐8 toward Chemo‐Photothermal Therapy

Aqueous Stable Gold Nanostar/ZIF‐8 Nanocomposites for Light‐Triggered Release of Active Cargo Inside Living Cells

Crosstalk between Autophagy and Nanomaterials: Internalization, Activation, Termination

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