Modulatory role of Shorea robusta bark on Glucose-metabolizing enzymes in diethylnitrosamine induced hepatocellular carcinoma in rats

Kalaiselvan, A.; Anand, T.; Gokulakrishnan, K.; Kamaraj, MC; Velavan, S

doi:10.4103/0973-1296.168981

Cited by 11 publications

(14 citation statements)

References 21 publications

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“…Carcinogenesis may arise as a result of chemical or biological damage to normal cells in a multistep process that involves changes at the initiation level followed by promotion and progression, which leads to malignancy. [37] The increment in the concentrations of serum total lipid, TC, TGs, and LDL-C with a reduction in the level of HDL-C in the TAA treated rats may reflect impairment of liver function, particularly in lipid metabolism. [38] The long-term regimen of TAA led to a significant decrease of hepatic markers; total protein and albumin levels indicating acute hepatocyte damage.…”

Section: Discussionmentioning

confidence: 99%

Synergistic curative effect of chicory extract and cisplatin against thioacetamide-induced hepatocellular carcinoma

Hassan¹,

Serag²,

Abdel-Hamid³

et al. 2015

Hepatoma Res

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Aim: Hepatocellular carcinoma (HCC) is the dominant form of primary liver cancer and is histologically and etiologically distinct from other forms of primary liver cancer. The objective of this study was to elucidate the synergistic effect and the role of chicory extract [inulin (IN)] as a chemo-sensitizer for cisplatin (CIS) treatment of HCC. Methods: Five groups of rats were treated for 4 months. These groups consisted of the control group, a group receiving thioacetamide (TAA) (200 mg/kg b.w) in drinking water, a group injected intraperitoneally with a single dose of CIS (7.5 mg/kg b.w) in addition to TAA for 4 months, a group receiving oral doses of IN (10 mg/kg b.w) in addition to TAA for 4 months, and a group injected intraperitoneally with a single dose of CIS (7.5 mg/kg b.w) and IN (10 mg/kg b.w) plus TAA for 4 months. Results: The current data exhibited increment of serum and liver enzyme ( alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, creatine kinase, and lactate dehydrogenase) activity, serum lipid profi le levels (total lipids, total cholesterol, triglycerides, low-density lipoprotein, and very low-density lipoprotein), and a signifi cant increase in α-fetoprotein and bilirubin, accompanied with reduced total serum protein and albumin levels in a HCC rat model. Histopathologically, numerous alterations were detected in hepatic tissues of HCC rats, such as lymphocytic cell infi ltration, damage of hepatocytes, dilated congested central vein with degenerated endothelial cells, and congested blood sinusoids in addition to Masson's trichrome staining blue collagen fi bers in hepatocytes and central vein indicating hepatic fi brosis. Treatment of HCC rats with CIS or IN improved such deleterious effects, where IN is more effective than CIS, and the best effect can be observed in rats that received both CIS and IN. Conclusion: It could be concluded that IN in chicory extract acts as a chemo-sensitizer to CIS for treatment in an HCC rat model. Key words: Chicory; cisplatin; hepatocellular carcinoma; inulin INTRODUCTIONCancer is one of the most anxiety-inducing diseases and it is presenting with further prolongation and increasing occurrence.[1] The most common and recurrent primary malignancy of the liver is recognized as hepatocellular carcinoma (HCC), a major malignancy worldwide and is increasingly associated with cancer-related death.[2] HCC represents the most common primary malignancy of the liver. According to epidemiological surveys, the prevalence Synergistic curative effect of chicory extract and cisplatin Synergistic curative effect of chicory extract and cisplatin against thioacetamide-induced hepatocellular carcinoma against thioacetamide-induced hepatocellular carcinoma This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the ...

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Section: Discussionmentioning

confidence: 99%

Synergistic curative effect of chicory extract and cisplatin against thioacetamide-induced hepatocellular carcinoma

Hassan¹,

Serag²,

Abdel-Hamid³

et al. 2015

Hepatoma Res

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“…Groups V (Treatment group) was given single dose of DEN same like group II but for 6 weeks, then treated with 500 mg/kg C. gileadensis bark extracts orally for further 4 weeks. All doses were used according to the effective dose fixation according to method of Kalaiselvan et al (2013). Aspartate aminotransferase (AST) (Schumann et al, 2002) and alanine aminotransferase (ALT) (Sonntag and Scholer, 2001), Alkaline phosphatase (ALP) (Abicht et al, 2001), lipid profile (Stein and Myers, 1995;Pisani et al, 1995;Bachoric, 2000) and complete blood count (CBC) were measured.…”

Section: Animal Study Designmentioning

confidence: 99%

Therapeutic and preventive effects of Commiphora gileadensis against diethylnitrosamine-induced hepatic injury in albino rats

Anwar¹,

Amani²,

Alzoreqy³

et al. 2016

Afr. J. Pharm. Pharmacol.

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Commiphora gileadensis is a tree in the burseraceae family, cultivated widely in Hadhramaut governorate (Yemen) and known locally as "Besham" or Balsam" used traditionally for many ailments. The aim of this study was to evaluate the therapeutic and preventive effects of C. gileadensis against diethylnitrosamine (DEN) -induced hepatic injury in albino rats. 40 albino rats were divided randomly into five groups (each contains 8 animals). Group I (Negative control) was given normal saline i.p and distilled water, group II (Positive control) toxicity-initiated with single dose of DEN 200 mg/kg i.p and promoted after 2 weeks with 0.05% of phenobarbitone in drinking water to complete 10 weeks. Group III was given 500 mg/kg extract of C. gileadensis bark for 10 weeks. Groups IV (preventive group) pretreated with 500 mg/kg extract of C. gileadensis bark and injected with DEN 200 mg/kg i.p for 10 weeks. Groups V (Treatment group) was given single dose of DEN same like group II but for 6 weeks, then treated with 500 mg/kg C. gileadensis bark extracts orally for an additional 4 weeks. All doses were used according to the effective dose fixation. Liver function enzymes, complete blood count (CBC) and lipid profile were measured. In addition, fasting blood sugar (FBS) and total body weight were taken weekly. At the end of experiment relative weight of liver was calculated. C. gileadensis showed significant hepatoprotective effect as it reduced the liver function enzyme's level, this effect was supported by hepatic histopathological improvement against DEN-induced hepatic injury. In addition, it demonstrated potent anti-platelets activity. The outcomes of this study suggested that C. gileadensis has novel hepatoprotective and remarkable anti-platelets effect.

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“…Shorea robusta resin was used for anti-aging activities especially for better skin health 4 . Bark extract of Shorea robusta on modulated immune response in rats 9 .…”

Section: Introductionmentioning

confidence: 99%

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2013

IJPSR

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ABSTRACT:Currently there has been an increased interest globally to identify the plant origin with free radical scavenging properties and have great importance as therapeutic agents in several diseases due to oxidative stress. Lipid peroxidation of cellular membranes has also been implicated in various disease processes, including cardiac ischemia-reperfusion injury. In recent years, the use of natural antioxidants present in food and other biological materials has attracted considerable interest due to their presumed safety, nutritional and therapeutic value. Shorea robusta has wide range of pharmacological activity but the cytoprotective activity against oxidative damage has not yet been documented. The present study was investigated the cytoprotective activity of Shorea robusta extract (SRE). The results of the study indicate that the cytoprotective role of SRE may be related to counteraction of free radicals. The mechanism of cytoprotective is to be worked out in future studies.

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Modulatory role of Shorea robusta bark on Glucose-metabolizing enzymes in diethylnitrosamine induced hepatocellular carcinoma in rats

Cited by 11 publications

References 21 publications

Synergistic curative effect of chicory extract and cisplatin against thioacetamide-induced hepatocellular carcinoma

Synergistic curative effect of chicory extract and cisplatin against thioacetamide-induced hepatocellular carcinoma

Therapeutic and preventive effects of Commiphora gileadensis against diethylnitrosamine-induced hepatic injury in albino rats

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