Modulatory role of dietary curcumin and resveratrol on growth performance, serum immunity responses, mucus enzymes activity, antioxidant capacity and serum and mucus biochemicals in the common carp, Cyprinus carpio exposed to abamectin

Rohmah, Martina Kurnia; Salahdin, Omar Dheyauldeen; Gupta, Reena; Muzammil, Khursheed; Qasim, Maytham T.; Al‐qaim, Zahraa Haleem; Abbas, Nada Fadhil; Jawad, Mohammed Abed; Mustafa, Yasser Fakri; Heidary, Aadel; Abarghouei, Safoura

doi:10.1016/j.fsi.2022.08.042

Cited by 37 publications

(33 citation statements)

References 93 publications

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“…On the other hand, fish fed quercetin-supplemented diets and exposed to ABM had lower glucose levels. In accordance with the present findings, curcumin and resveratrol succeeded in mitigating the stress response induced by ABM by decreasing cortisol and glucose levels [ 19 ]. Furthermore, Yan, et al [ 82 ] reported that quercetin can lower blood glucose levels via protecting pancreatic cells and/or improving insulin sensitivity.…”

Section: Discussionsupporting

confidence: 91%

“…This could be attributed to the action of phenolic constituents found in quercetin in improving metabolism [ 75 ]. In accordance, dietary supplementation with curcumin and resveratrol alleviated the effect of ABM on the common carp plasma biochemical parameters [ 19 ].…”

Section: Discussionmentioning

confidence: 96%

“…In addition, protein may be utilized as a source of energy for repair of the damaged cells and compensate for stress induced-energy consumption [ 67 , 72 , 73 , 74 ]. The levels of some plasma immune components were significantly reduced in ABM-exposed common carp, including albumin, lysozyme, complement activity, and total immunoglobulin [ 19 ]. The decrease in blood proteins and related substances in the present study could be attributed to the impairment of protein synthesis in the liver or protein excretion by the kidney due to ABM-inducing liver and kidney failure [ 67 ].…”

Section: Discussionmentioning

confidence: 99%

“…Concurrent with recent reports, Mahmoud, et al [ 15 ] reported that the augmented levels of ALT and AST post-exposure of Nile tilapia to ABM restored by dietary supplementation of Simmondsia chinensis extract. The negative impact of ABM on liver integrity was mitigated by curcumin and resveratrol supplementation, whereas the activities of AST, ALP, and lactate dehydrogenase significantly decreased in the group exposed to ABM and fed different dietary supplements [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…In fish, different responses from acute to chronic toxicity have been reported with ABM exposure. The reported adverse effects of ABM on fishes were behavioral changes, growth depression, hematological and biochemical disturbances, hepatorenal toxicity, immune depression, and oxidative stress, as reported in Zebra fish, Danio rerio [ 12 ], hybrid catfish, Clarias macrocephalus × C. gariepinus [ 13 ], Nile tilapia, Oreochromis niloticus [ 14 , 15 ], O. mossambicus [ 16 ], African catfish, C. gariepinus [ 17 , 18 ], and common carp, Cyprince carpio [ 19 ]. In addition, the exposure to chemical pollutants in aquatic animals induces hypergeneration of free radicals [ 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 96%

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Ameliorative Effect of Quercetin against Abamectin-Induced Hemato-Biochemical Alterations and Hepatorenal Oxidative Damage in Nile Tilapia, Oreochromis niloticus

Mansour

Mahboub

Amen

et al. 2022

Animals

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Abamectin (ABM) is a common agricultural pesticide and veterinary anthelmintic drug. It can discharge from the sites of application to aquatic systems via surface run-off or spray drift, causing harmful effects to aquatic organisms. The present study investigated the protective effect of dietary quercetin supplementation on hemato-biochemical parameters and hepato-renal oxidative stress biomarkers in Nile tilapia (Oreochromis niloticus) exposed to a sublethal dose of ABM. Fish were allocated into six equal groups. The first group was kept as a control group. The second and third groups (Q400, and Q800) were fed diets supplemented with two quercetin levels (400 and 800 mg/kg diet), respectively. The fourth group (ABM) was intoxicated with 20.73 µg/L of ABM. The fifth and sixth groups (ABM + Q400, and ABM + Q800) were fed diet supplemented with two quercetin levels (400 and 800 mg/kg diet) and simultaneously intoxicated with ABM for 60 days. The results showed that ABM significantly decreased RBCs, hemoglobin content, hematocrit, total protein, albumin levels, and acetylcholinesterase activity activities compared to the control. Meanwhile, ABM significantly increased white blood cells, glucose, total lipids, cholesterol, and alanine and aspartate aminotransferase activities. Liver and kidney levels of lipid peroxidation was significantly increased, while hepato-renal antioxidant biomarkers (reduced glutathione, super oxide dismutase, catalase, and total antioxidant capacity) were significantly decreased upon ABM exposure. On the other hand, quercetin dietary supplementation improved the hemato-biochemical alterations and alleviated oxidative stress induced by ABM exposure. Fish supplemented with quercetin at a level of 800 mg/kg diet showed better alleviating effects against ABM compared to 400 mg/kg diet. Based on these study findings, we suggest that quercetin dietary supplementation (800 mg/kg) offered direct protection against ABM-induced physiological disturbance and oxidative stress in Nile tilapia.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 96%