Modulatory effects of quercetin on liver histopathological, biochemical, hematological, oxidative stress and DNA alterations in rats exposed to graded doses of score 250

Kasmi, Sabrine; Bkhairia, Intithar; Harrabi, Bahira; Mnif, Héla; Marrakchi, Rim; Ghozzi, H.; Kallel, Choumous; Zeghal, Khaled Mounir; Jamoussi, Kamel; Hakim, Ahmed

doi:10.1080/15376516.2017.1351507

Cited by 26 publications

(20 citation statements)

References 49 publications

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“…As a result, the amount of these parameters in the blood is directly associated with the amount of liver injured. The results reported in this study are in agreement with previous studies, which indicated that exposure to malathion and other pesticides induced severe adverse biochemical alterations that affect the functional and structural integrity of the liver tissues in experimental animals (Al-Attar, 2010; Al-Attar, 2015; Kasmi et al, 2018;Selmi et al, 2018;Aboubakr et al, 2019;Jalili et al, 2019;Khalifa and Alkhalf, 2019).…”

Section: Discussionsupporting

confidence: 92%

“…Hematological characteristics have been widely used in the diagnosis of variety of diseases and pathologies induced by different toxicant including pesticides. Previous studies showed that RBC and WBC counts, and Hb and Hct values were significantly decreased in experimental rats exposed to malathion and different pesticides (Moallem et al, 2014;Aroonvilairat et al, 2018;Kasmi et al, 2018;Mohi El-Din et al, 2018;Khalifa and Alkhalf, 2019). Shakoori et al (1990) suggested that the decrease in RBC count is either indicative of excessive damage to erythrocytes or inhibition of erythrocyte formation.…”

Section: Discussionmentioning

confidence: 97%

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The Potential Protective Effect of Sesame Oil and Canola Oil on Rats Exposed to Malathion

2019

Curr. Sci. Int.

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Currently, the environmental pollution is occurring on a vast and unprecedented scale around the globe. Pesticides are the largest group of chemicals that are used widely in modern agricultural practices. Pesticides have been associated with health and environmental issues, and the agricultural use of certain pesticides has been abandoned. Pesticides are basically poisons and therefore toxic to living organism at particular dose. Medicinal plants have a promising future because there are about half million plants around the world, and most of them their medical activities have not investigate yet, and their medical activities could be decisive in the treatment of present or future studies. Natural products from plants, animals and minerals are the basis for treating human diseases. The purpose of the present study was to evaluate the effects of sesame oil and canola oil on male rats exposed to malathion. Experimental rats were divided into six groups. Group 1 was served as normal control. Rats of group 2 were exposed to malathion. Rats of group 3 were treated with sesame oil and malathion. Rats of group 4 were subjected to canola oil and malathion. Rats of group 5 and 6 were supplemented with sesame oil and canola oil respectively. After the end of experimental duration (8 weeks), rats of group 2 showed significant reduction of body weight gain, and severe hematological and biochemical alterations including significant decreases of RBC, HB, Hct, WBC, total protein, glucose and CAT, and increases of ALT, AST, ALP, total bilirubin, triglycerides, cholesterol, creatinine, uric acid and MDA values. Administration of sesame oil and canola oil improved the observed hematological and biochemical alterations induced by malathion intoxication. These new findings indicate that sesame oil and canola oil represent protective roles on hematological and biochemical disturbances induced by malathion toxicity due to their antioxidant activities.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 97%

The Potential Protective Effect of Sesame Oil and Canola Oil on Rats Exposed to Malathion

2019

Curr. Sci. Int.

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“…Mancozeb is a site non-specific fungicide and evolution of resistance in the pathogen would involve changes in multiple genes across the A. alternata genome [13]. Though difenoconazole is a site-specific fungicide targeting CYP51, other mechanisms such as alteration in sterol biosynthesis pathways [28], increased active efflux by ABC transporters [29] and changes in cell membrane integrity and cell composition [30] also contributed to the building of drug resistance.…”

Section: Discussionmentioning

confidence: 99%

Cross-resistance of the pathogenic fungus Alternaria alternata to fungicides with different modes of action

Yang

Ouyang

et al. 2019

Preprint

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Background: Cross-resistance, a phenomenon that a pathogen resists to one antimicrobial compound also resists to one or several other compounds, is one of major threats to human health and sustainable food production. It usually occurs among antimicrobial compounds sharing the mode of action. In this study, we determined the sensitivity profiles of Alternaria alternata , a fungal pathogen which can cause diseases in many crops to two fungicides (mancozeb and difenoconazole) with different mode of action using a large number of isolates (234) collected from seven potato fields across China. Results: We found that pathogens could also develop cross resistance to fungicides with different modes of action as indicated by a strong positive correlation between mancozeb and difenoconazole tolerances to A. alternata . We also found a positive association between mancozeb tolerance and aggressiveness of A. alternata , suggesting no fitness penalty of developing mancozeb resistance in the pathogen and hypothesize that mechanisms such as antimicrobial compound efflux and detoxification that limit intercellular accumulation of natural/synthetic chemicals in pathogens might account for the cross-resistance and the positive association between pathogen aggressiveness and mancozeb tolerance. Conclusions: The detection of cross-resistance among different classes of fungicides suggests that the mode of action alone may not be an adequate sole criterion to determine what components to use in the mixture and/or rotation of fungicides in agricultural and medical sects. Similarly, the observation of a positive association between the pathogen’s aggressiveness and tolerance to mancozeb suggests that intensive application of site non-specific fungicides might simultaneously lead to reduced fungicide resistance and enhanced ability to cause diseases in pathogen populations, thereby posing a greater threat to agricultural production and human health. In this case, the use of evolutionary principles in closely monitoring populations and the use of appropriate fungicide applications are important for effective use of the fungicides and durable infectious disease management.

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“…43 In addition to the above-mentioned studies, an increase in liver AOPPs was also noted in methylthiophanate-, 44 acrylamide- 45 and difenoconazole-treated rats. 46 Although many studies have referred to the profound effects of AOPPs on the progression of diverse liver damages, there have been few studies investigating the potential mechanisms. The latest study revealed a novel pathogenic role of AOPPs in the hepatocyte cell cycle and liver regeneration.…”

Section: Aopps In Models Of Liver Damage Induction and The Potentiamentioning

confidence: 99%

Advanced oxidation protein products play critical roles in liver diseases

Zhao

Zhang

Ouyang

et al. 2019

Eur J Clin Investigation

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There is a complex oxidant and antioxidant system that maintains the redox homoeostasis in the liver. While suffering from exogenous or endogenous risk factors, the balance between oxidants and antioxidants is disturbed and excessive reactive oxygen species are generated, resulting in oxidative stress. Oxidative stress is prevalent in various liver diseases and is thought to be involved in their pathophysiology. Advanced oxidation protein products are generated under conditions of oxidative damage and are newly described protein markers of oxidative stress. Previous studies have underscored the universal pathogenic roles of oxidation protein products in various diseases. However, investigations into how these products participate in the development of liver diseases have been superficial and insufficient. In this review, we highlight the current understanding of the roles of advanced oxidation protein products in liver disease pathogenesis and the underlying mechanisms. Moreover, we summarize the current studies on advanced oxidation protein products in infectious and noninfectious, acute and chronic liver diseases. Different strategies for targeting these advanced oxidation protein products and future perspectives, which may pave the way for developing new therapeutic strategies, will also be discussed here.

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Modulatory effects of quercetin on liver histopathological, biochemical, hematological, oxidative stress and DNA alterations in rats exposed to graded doses of score 250

Cited by 26 publications

References 49 publications

The Potential Protective Effect of Sesame Oil and Canola Oil on Rats Exposed to Malathion

The Potential Protective Effect of Sesame Oil and Canola Oil on Rats Exposed to Malathion

Cross-resistance of the pathogenic fungus Alternaria alternata to fungicides with different modes of action

Advanced oxidation protein products play critical roles in liver diseases

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