Modulatory effects of preoptic stimulation on hypothalamically-elicited attack in cats

Predatory attack behavior in the cat elicited by preoptic region stimulation: A comparison with behavior elicited by hypothalamic and midbrain stimulation

“…Within the lateral hypothalamus and ventral tegmental area electrodes implanted only within a much narrower (approximately 0.5-I .OO mm) medial-la teral zonc elicit predatory behavior. These histological findings are seemingly in sharp contrast to the earlier report of Inselman and Flynn [1972] that attack behavior is elicited only from the medial preoptic area and the more medial portions of the lateral preoptic area. One difference in these two studies is that from their histology it appears Inselman and Flynn implanted only 29 electrodes in the preoptic region in contrast to the 84 (including the seizureyielding electrodes) electrodes of this study.…”

“…Within the more rostral reaches of the preoptic region (Ant 15.0-16.0) we found that eight of 10 attack electrodes were either in the medial preoptic region or the medial portions of the lateral preoptic region and this is in substantial agreement with Inselman and Flynn [ 19721 . A second factor that may have contributed to the differences in the two studies is that Inselman and Flynn [1972] used a maximum stimulation intensity of 800 PA. Of the 19 preoptic attack-eliciting electrodes in this study, only 10 electrodes elicited reliable attack at intensities of 800 PA or less, although it should be noted that three of these were in the lateral portions of the lateral preoptic region. The different results of the two studies then, are seemingly reconcilable.…”

Projections of the Midlateral Posterior Hypothalamic Area Influencing Cardiorespiratory Function in Rats

“…The area has been shown by a variety of neuroanatomical techniques to be a conduit for axons from the hippocampus [Nauta, 1956], septum [Nauta, 1956;Valenstein and Nauta, 1959], habenula [Herkenham and Nauta, 1979], medial hypothalamus [Conrad and Pfaff, 1976], lateral hypothalamus [Saper et al, 1979;Hosoya and Matsushita, 1981], anterior hypothala mus [Conrad and Pfaff, 1976;Swanson, 1976], thala mus [Herkenham, 1978], cingulate cortex [Beckstead, 1979;Domesick, 1969], and prefrontal cortex [Le onard, 1969;Beckstead, 1979]. Stimulation of many of these source areas also induces alterations in car diorespiratory function in unanesthetized and anesthetized animals including man [Sano et al, 1970;Siegel and Chabora, 1971;Siegel and Skog, 1971;Inselman and Flynn, 1972]. Redgate [1960] first at tempted to avoid stimulation of fibers of passage through the posterior hypothalamus by using intra cerebral injections of thiopental.…”

Predatory Behavior in the Cat Elicited by Lower Brain Stem and Hypothalamic Stimulation: a Comparison

“…This behavior was first reported during electrical stimulation of the lateral hypothalamus [Wasman and F lynn, 1962]. Since then, forms of the behavior have been reported to be a con sequence of electrical stimulation of the medial and mediolateral pre optic area [Inselman and F lynn, 1972], posterior midline thalamus MacDonnell and F lynn, 1968], ventral tegmental area of the midbrain [Bandler et al, 1972;Proshansky and B andler, 1975;P roshansky et a i , 1974], dorsolateral reticular forma tion [Sheard and F lynn, 1967], central pontine tegmentum [Berntson, 1973] and the region of the fastigial nucleus of the cerebellum [Reis et a i , 1973]. Recently we reported that predatory behavior could also be elicited by stimulation within and adjacent to the ventromedial periaque ductal gray matter at the junction of the midbrain and pons [Bandler, 1975].…”